Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.021 0.12 -9999.0 0.0 -0.541 16.0 16.0 IHH 0.014 0.049 -9999.0 0.0 -0.441 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.116 0.202 -9999.0 0.0 -0.445 107.0 107.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.115 0.2 0.442 107.0 -9999.0 0.0 107.0 SMO/beta Arrestin2 0.005 0.089 -9999.0 0.0 -0.479 4.0 4.0 SMO -0.0 0.093 -9999.0 0.0 -0.455 7.0 7.0 AKT1 0.018 0.046 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.013 0.087 -9999.0 0.0 -0.32 31.0 31.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.0 0.092 -9999.0 0.0 -0.448 7.0 7.0 STIL -0.068 0.176 -9999.0 0.0 -0.517 7.0 7.0 DHH N/PTCH2 0.008 0.044 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.018 0.078 -9999.0 0.0 -0.58 2.0 2.0 PIK3CA 0.012 0.001 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.002 0.064 -9999.0 0.0 -0.32 16.0 16.0 PTHLH 0.015 0.152 -9999.0 0.0 -0.824 10.0 10.0 determination of left/right symmetry -0.0 0.092 -9999.0 0.0 -0.448 7.0 7.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.015 0.15 -9999.0 0.0 -0.814 10.0 10.0 IHH N/Hhip -0.029 0.107 -9999.0 0.0 -0.419 5.0 5.0 DHH N/Hhip -0.031 0.099 -9999.0 0.0 -0.405 6.0 6.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.0 0.092 -9999.0 0.0 -0.448 7.0 7.0 pancreas development -0.046 0.125 -9999.0 0.0 -0.32 72.0 72.0 HHAT 0.009 0.028 -9999.0 0.0 -0.32 3.0 3.0 PI3K 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.038 0.124 -9999.0 0.0 -0.333 60.0 60.0 somite specification -0.0 0.092 -9999.0 0.0 -0.448 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.075 0.185 -9999.0 0.0 -0.378 107.0 107.0 SHH Np/Cholesterol/PTCH2 -0.091 0.19 -9999.0 0.0 -0.418 105.0 105.0 SHH Np/Cholesterol/Megalin -0.126 0.22 -9999.0 0.0 -0.448 127.0 127.0 SHH -0.122 0.238 -9999.0 0.0 -0.532 105.0 105.0 catabolic process 0.021 0.077 -9999.0 0.0 -0.47 4.0 4.0 SMO/Vitamin D3 -0.064 0.176 -9999.0 0.0 -0.553 7.0 7.0 SHH Np/Cholesterol/Hhip -0.12 0.193 -9999.0 0.0 -0.431 107.0 107.0 LRP2 -0.047 0.187 -9999.0 0.0 -0.707 31.0 31.0 receptor-mediated endocytosis -0.073 0.178 -9999.0 0.0 -0.526 18.0 18.0 SHH Np/Cholesterol/BOC -0.104 0.193 -9999.0 0.0 -0.426 106.0 106.0 SHH Np/Cholesterol/CDO -0.091 0.19 -9999.0 0.0 -0.418 105.0 105.0 mesenchymal cell differentiation 0.119 0.191 0.428 107.0 -9999.0 0.0 107.0 mol:Vitamin D3 -0.073 0.185 -9999.0 0.0 -0.376 107.0 107.0 IHH N/PTCH2 0.015 0.039 -9999.0 0.0 -0.264 2.0 2.0 CDON 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.023 0.079 -9999.0 0.0 -0.475 4.0 4.0 Megalin/LRPAP1 -0.027 0.143 -9999.0 0.0 -0.531 31.0 31.0 PTCH2 0.012 0.001 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.098 0.189 -9999.0 0.0 -0.423 105.0 105.0 PTCH1 0.021 0.078 -9999.0 0.0 -0.472 4.0 4.0 HHIP -0.046 0.125 -9999.0 0.0 -0.32 72.0 72.0