Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.057 0.163 0.402 97.0 -9999.0 0.0 97.0 KIRREL -0.029 0.14 -9999.0 0.0 -0.583 34.0 34.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.057 0.163 -9999.0 0.0 -0.403 97.0 97.0 PLCG1 0.01 0.025 -9999.0 0.0 -0.581 1.0 1.0 ARRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.056 0.155 -9999.0 0.0 -0.379 84.0 84.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.022 0.112 -9999.0 0.0 -0.346 35.0 35.0 FYN -0.041 0.126 -9999.0 0.0 -0.342 62.0 62.0 mol:Ca2+ -0.039 0.133 -9999.0 0.0 -0.365 58.0 58.0 mol:DAG -0.039 0.134 -9999.0 0.0 -0.366 58.0 58.0 NPHS2 -0.021 0.091 -9999.0 0.0 -0.465 22.0 22.0 mol:IP3 -0.039 0.134 -9999.0 0.0 -0.366 58.0 58.0 regulation of endocytosis -0.031 0.12 -9999.0 0.0 -0.324 58.0 58.0 Nephrin/NEPH1/podocin/Cholesterol -0.046 0.132 -9999.0 0.0 -0.368 58.0 58.0 establishment of cell polarity -0.057 0.163 -9999.0 0.0 -0.402 97.0 97.0 Nephrin/NEPH1/podocin/NCK1-2 -0.029 0.125 -9999.0 0.0 -0.475 17.0 17.0 Nephrin/NEPH1/beta Arrestin2 -0.031 0.122 -9999.0 0.0 -0.327 58.0 58.0 NPHS1 -0.057 0.171 -9999.0 0.0 -0.51 70.0 70.0 Nephrin/NEPH1/podocin -0.04 0.127 -9999.0 0.0 -0.344 62.0 62.0 TJP1 0.01 0.025 -9999.0 0.0 -0.581 1.0 1.0 NCK1 0.009 0.035 -9999.0 0.0 -0.581 2.0 2.0 NCK2 0.01 0.025 -9999.0 0.0 -0.581 1.0 1.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.039 0.134 -9999.0 0.0 -0.368 58.0 58.0 CD2AP -0.018 0.129 -9999.0 0.0 -0.577 29.0 29.0 Nephrin/NEPH1/podocin/GRB2 -0.038 0.133 -9999.0 0.0 -0.362 58.0 58.0 GRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.049 0.147 -9999.0 0.0 -0.385 69.0 69.0 cytoskeleton organization -0.026 0.131 -9999.0 0.0 -0.403 39.0 39.0 Nephrin/NEPH1 -0.039 0.118 -9999.0 0.0 -0.285 97.0 97.0 Nephrin/NEPH1/ZO-1 -0.037 0.135 -9999.0 0.0 -0.375 58.0 58.0