Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.008 0.115 0.353 49.0 -9999.0 0.0 49.0 KIRREL 0.001 0.105 -9999.0 0.0 -0.457 27.0 27.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.008 0.116 -9999.0 0.0 -0.353 49.0 49.0 PLCG1 0.015 0.023 -9999.0 0.0 -0.444 1.0 1.0 ARRB2 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.02 0.121 -9999.0 0.0 -0.278 74.0 74.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.002 0.084 -9999.0 0.0 -0.262 48.0 48.0 FYN -0.023 0.09 0.203 23.0 -0.254 51.0 74.0 mol:Ca2+ 0.017 0.085 -9999.0 0.0 -0.28 32.0 32.0 mol:DAG 0.018 0.086 -9999.0 0.0 -0.281 32.0 32.0 NPHS2 -0.004 0.037 -9999.0 0.0 -0.141 2.0 2.0 mol:IP3 0.018 0.086 -9999.0 0.0 -0.281 32.0 32.0 regulation of endocytosis 0.02 0.089 -9999.0 0.0 -0.239 51.0 51.0 Nephrin/NEPH1/podocin/Cholesterol 0.022 0.094 -9999.0 0.0 -0.266 48.0 48.0 establishment of cell polarity 0.008 0.115 -9999.0 0.0 -0.353 49.0 49.0 Nephrin/NEPH1/podocin/NCK1-2 0.048 0.1 -9999.0 0.0 -0.254 49.0 49.0 Nephrin/NEPH1/beta Arrestin2 0.021 0.09 -9999.0 0.0 -0.241 51.0 51.0 NPHS1 0.001 0.109 -9999.0 0.0 -0.448 28.0 28.0 Nephrin/NEPH1/podocin 0.023 0.093 -9999.0 0.0 -0.255 51.0 51.0 TJP1 0.024 0.021 -9999.0 0.0 -0.444 1.0 1.0 NCK1 0.025 0.028 -9999.0 0.0 -0.444 2.0 2.0 NCK2 0.026 0.02 -9999.0 0.0 -0.444 1.0 1.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.019 0.087 -9999.0 0.0 -0.282 32.0 32.0 CD2AP 0.004 0.101 -9999.0 0.0 -0.444 27.0 27.0 Nephrin/NEPH1/podocin/GRB2 0.036 0.1 -9999.0 0.0 -0.27 48.0 48.0 GRB2 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.036 0.101 0.219 22.0 -0.279 59.0 81.0 cytoskeleton organization -0.02 0.094 0.198 5.0 -0.312 46.0 51.0 Nephrin/NEPH1 0.011 0.083 -9999.0 0.0 -0.246 49.0 49.0 Nephrin/NEPH1/ZO-1 0.022 0.101 -9999.0 0.0 -0.287 49.0 49.0