Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.031 0.163 -9999.0 0.0 -0.561 40.0 40.0 IHH -0.012 0.136 -9999.0 0.0 -0.448 44.0 44.0 SHH Np/Cholesterol/GAS1 -0.018 0.108 0.187 2.0 -0.254 93.0 95.0 LRPAP1 0.025 0.02 -9999.0 0.0 -0.444 1.0 1.0 dorsoventral neural tube patterning 0.018 0.107 0.253 93.0 -0.185 2.0 95.0 SMO/beta Arrestin2 -0.022 0.161 -9999.0 0.0 -0.417 59.0 59.0 SMO -0.037 0.161 -9999.0 0.0 -0.421 66.0 66.0 AKT1 -0.026 0.146 -9999.0 0.0 -0.428 42.0 42.0 ARRB2 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.025 0.063 -9999.0 0.0 -0.444 9.0 9.0 ADRBK1 0.026 0.021 -9999.0 0.0 -0.444 1.0 1.0 heart looping -0.035 0.159 -9999.0 0.0 -0.415 66.0 66.0 STIL -0.022 0.125 0.18 28.0 -0.332 53.0 81.0 DHH N/PTCH2 0.009 0.109 -9999.0 0.0 -0.343 47.0 47.0 DHH N/PTCH1 -0.013 0.134 -9999.0 0.0 -0.291 95.0 95.0 PIK3CA 0.025 0.028 -9999.0 0.0 -0.444 2.0 2.0 DHH 0.002 0.103 -9999.0 0.0 -0.444 28.0 28.0 PTHLH -0.055 0.235 -9999.0 0.0 -0.833 39.0 39.0 determination of left/right symmetry -0.035 0.159 -9999.0 0.0 -0.415 66.0 66.0 PIK3R1 0.024 0.028 -9999.0 0.0 -0.444 2.0 2.0 skeletal system development -0.054 0.232 -9999.0 0.0 -0.812 40.0 40.0 IHH N/Hhip -0.023 0.153 -9999.0 0.0 -0.363 88.0 88.0 DHH N/Hhip -0.012 0.138 -9999.0 0.0 -0.343 80.0 80.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.035 0.159 -9999.0 0.0 -0.415 66.0 66.0 pancreas development -0.021 0.146 -9999.0 0.0 -0.444 59.0 59.0 HHAT 0.022 0.044 -9999.0 0.0 -0.444 5.0 5.0 PI3K 0.035 0.031 -9999.0 0.0 -0.321 4.0 4.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.024 0.163 -9999.0 0.0 -0.444 72.0 72.0 somite specification -0.035 0.159 -9999.0 0.0 -0.415 66.0 66.0 SHH Np/Cholesterol/PTCH1 -0.021 0.124 -9999.0 0.0 -0.3 81.0 81.0 SHH Np/Cholesterol/PTCH2 -0.001 0.079 -9999.0 0.0 -0.25 49.0 49.0 SHH Np/Cholesterol/Megalin 0.01 0.064 0.187 2.0 -0.251 29.0 31.0 SHH -0.026 0.067 0.234 1.0 -0.32 27.0 28.0 catabolic process -0.018 0.123 -9999.0 0.0 -0.322 73.0 73.0 SMO/Vitamin D3 -0.03 0.15 -9999.0 0.0 -0.381 69.0 69.0 SHH Np/Cholesterol/Hhip -0.016 0.105 0.187 2.0 -0.266 78.0 80.0 LRP2 0.011 0.033 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.034 0.145 -9999.0 0.0 -0.401 56.0 56.0 SHH Np/Cholesterol/BOC 0.009 0.071 0.187 2.0 -0.254 35.0 37.0 SHH Np/Cholesterol/CDO 0.007 0.066 -9999.0 0.0 -0.253 32.0 32.0 mesenchymal cell differentiation 0.016 0.104 0.265 78.0 -0.185 2.0 80.0 mol:Vitamin D3 -0.013 0.134 0.199 31.0 -0.313 72.0 103.0 IHH N/PTCH2 -0.001 0.12 -9999.0 0.0 -0.341 56.0 56.0 CDON 0.023 0.045 -9999.0 0.0 -0.444 5.0 5.0 IHH N/PTCH1 -0.007 0.128 -9999.0 0.0 -0.324 73.0 73.0 Megalin/LRPAP1 0.039 0.023 -9999.0 0.0 -0.324 1.0 1.0 PTCH2 0.008 0.094 -9999.0 0.0 -0.444 23.0 23.0 SHH Np/Cholesterol -0.0 0.057 -9999.0 0.0 -0.242 29.0 29.0 PTCH1 -0.018 0.124 -9999.0 0.0 -0.323 73.0 73.0 HHIP -0.021 0.146 -9999.0 0.0 -0.444 59.0 59.0