Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.017 0.034 -9999.0 0.0 -0.232 10.0 10.0 epithelial cell differentiation 0.053 0.025 -9999.0 0.0 -0.233 3.0 3.0 CYFIP2 0.019 0.059 -9999.0 0.0 -0.444 9.0 9.0 ENAH -0.026 0.049 0.264 1.0 -0.386 4.0 5.0 EGFR 0.02 0.045 -9999.0 0.0 -0.444 5.0 5.0 EPHA2 0.024 0.029 -9999.0 0.0 -0.444 2.0 2.0 MYO6 -0.016 0.022 0.172 3.0 -0.227 3.0 6.0 CTNNB1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.046 0.05 -9999.0 0.0 -0.294 11.0 11.0 AQP5 -0.01 0.096 -9999.0 0.0 -0.442 25.0 25.0 CTNND1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.016 0.026 0.171 5.0 -0.224 4.0 9.0 regulation of calcium-dependent cell-cell adhesion -0.03 0.059 0.18 5.0 -0.231 38.0 43.0 EGF -0.03 0.172 -9999.0 0.0 -0.444 80.0 80.0 NCKAP1 0.025 0.028 -9999.0 0.0 -0.444 2.0 2.0 AQP3 0.003 0.06 -9999.0 0.0 -0.428 9.0 9.0 cortical microtubule organization 0.053 0.025 -9999.0 0.0 -0.233 3.0 3.0 GO:0000145 -0.015 0.024 0.158 5.0 -0.214 4.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.058 0.026 -9999.0 0.0 -0.235 3.0 3.0 MLLT4 0.025 0.02 -9999.0 0.0 -0.444 1.0 1.0 ARF6/GDP -0.027 0.029 -9999.0 0.0 -0.273 6.0 6.0 ARF6 0.024 0.021 -9999.0 0.0 -0.444 1.0 1.0 Ephrin A1/EPHA2/NCK1/GIT1 0.058 0.039 -9999.0 0.0 -0.305 4.0 4.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.005 0.02 0.166 1.0 -0.212 4.0 5.0 PVRL2 0.026 0.02 -9999.0 0.0 -0.444 1.0 1.0 ZYX -0.017 0.021 0.172 1.0 -0.227 4.0 5.0 ARF6/GTP 0.061 0.045 -9999.0 0.0 -0.335 4.0 4.0 CDH1 0.026 0.02 -9999.0 0.0 -0.444 1.0 1.0 EGFR/EGFR/EGF/EGF 0.01 0.098 -9999.0 0.0 -0.224 78.0 78.0 RhoA/GDP 0.053 0.028 -9999.0 0.0 -0.226 4.0 4.0 actin cytoskeleton organization -0.018 0.022 0.159 2.0 -0.219 5.0 7.0 IGF-1R heterotetramer 0.025 0.021 -9999.0 0.0 -0.444 1.0 1.0 GIT1 0.025 0.02 -9999.0 0.0 -0.444 1.0 1.0 IGF1R 0.025 0.021 -9999.0 0.0 -0.444 1.0 1.0 IGF1 -0.008 0.133 -9999.0 0.0 -0.444 47.0 47.0 DIAPH1 0.028 0.133 -9999.0 0.0 -0.581 22.0 22.0 Wnt receptor signaling pathway -0.053 0.025 0.233 3.0 -9999.0 0.0 3.0 RHOA 0.025 0.02 -9999.0 0.0 -0.444 1.0 1.0 RhoA/GTP -0.028 0.029 -9999.0 0.0 -0.264 7.0 7.0 CTNNA1 0.025 0.028 -9999.0 0.0 -0.444 2.0 2.0 VCL -0.018 0.023 0.16 2.0 -0.223 5.0 7.0 EFNA1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.018 0.025 0.163 5.0 -0.221 4.0 9.0 Ephrin A1/EPHA2 0.044 0.031 -9999.0 0.0 -0.224 5.0 5.0 SEC6/SEC8 -0.025 0.02 -9999.0 0.0 -0.218 5.0 5.0 MGAT3 -0.03 0.059 0.182 5.0 -0.234 38.0 43.0 HGF/MET 0.032 0.067 -9999.0 0.0 -0.223 34.0 34.0 HGF 0.001 0.108 -9999.0 0.0 -0.444 31.0 31.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.017 0.035 -9999.0 0.0 -0.234 10.0 10.0 actin cable formation -0.011 0.071 0.228 15.0 -0.314 9.0 24.0 KIAA1543 -0.016 0.024 0.159 5.0 -0.217 4.0 9.0 KIFC3 -0.019 0.029 0.172 1.0 -0.228 9.0 10.0 NCK1 0.025 0.028 -9999.0 0.0 -0.444 2.0 2.0 EXOC3 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.015 0.024 0.172 5.0 -0.227 3.0 8.0 NCK1/GIT1 0.036 0.027 -9999.0 0.0 -0.32 3.0 3.0 mol:GDP 0.053 0.025 -9999.0 0.0 -0.233 3.0 3.0 EXOC4 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.017 0.02 0.172 2.0 -0.227 3.0 5.0 PIP5K1C -0.016 0.026 0.172 5.0 -0.227 4.0 9.0 LIMA1 0.021 0.052 -9999.0 0.0 -0.444 7.0 7.0 ABI1 0.026 0.02 -9999.0 0.0 -0.444 1.0 1.0 ROCK1 -0.021 0.052 0.255 4.0 -0.428 2.0 6.0 adherens junction assembly -0.007 0.059 0.267 4.0 -0.397 6.0 10.0 IGF-1R heterotetramer/IGF1 0.026 0.08 -9999.0 0.0 -0.227 48.0 48.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.037 0.023 -9999.0 0.0 -0.32 2.0 2.0 MET 0.025 0.021 -9999.0 0.0 -0.444 1.0 1.0 PLEKHA7 -0.016 0.026 0.172 5.0 -0.227 4.0 9.0 mol:GTP 0.056 0.038 -9999.0 0.0 -0.303 4.0 4.0 establishment of epithelial cell apical/basal polarity -0.016 0.052 0.312 3.0 -9999.0 0.0 3.0 cortical actin cytoskeleton stabilization 0.017 0.034 -9999.0 0.0 -0.232 10.0 10.0 regulation of cell-cell adhesion -0.018 0.022 0.159 2.0 -0.219 5.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.017 0.035 -9999.0 0.0 -0.234 10.0 10.0