Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling mediated by p38-alpha and p38-beta	83.0	3688.0	44.0	-0.125	0.026	1000.0	-1000.0	-0.02	-1000.0
IL23-mediated signaling events	76.0	4589.0	60.0	-0.409	0.026	1000.0	-1000.0	-0.105	-1000.0
IL4-mediated signaling events	73.0	6672.0	91.0	-0.563	0.469	1000.0	-1000.0	-0.124	-1000.0
FOXA2 and FOXA3 transcription factor networks	52.0	2403.0	46.0	-0.272	0.027	1000.0	-1000.0	-0.1	-1000.0
Endothelins	50.0	4845.0	96.0	-0.118	0.03	1000.0	-1000.0	-0.048	-1000.0
Wnt signaling	47.0	335.0	7.0	-0.071	0.019	1000.0	-1000.0	-0.013	-1000.0
Signaling events mediated by the Hedgehog family	46.0	2396.0	52.0	-0.055	0.039	1000.0	-1000.0	-0.032	-1000.0
TCR signaling in naïve CD8+ T cells	46.0	4319.0	93.0	-0.085	0.039	1000.0	-1000.0	-0.044	-1000.0
Osteopontin-mediated events	45.0	1710.0	38.0	-0.083	0.03	1000.0	-1000.0	-0.042	-1000.0
Noncanonical Wnt signaling pathway	45.0	1175.0	26.0	-0.074	0.025	1000.0	-1000.0	-0.045	-1000.0
HIF-1-alpha transcription factor network	45.0	3495.0	76.0	-0.152	0.029	1000.0	-1000.0	-0.072	-1000.0
Fc-epsilon receptor I signaling in mast cells	45.0	4433.0	97.0	-0.141	0.048	1000.0	-1000.0	-0.051	-1000.0
Ephrin B reverse signaling	45.0	2166.0	48.0	-0.098	0.038	1000.0	-1000.0	-0.024	-1000.0
Reelin signaling pathway	42.0	2371.0	56.0	-0.065	0.067	1000.0	-1000.0	-0.04	-1000.0
TCGA08_p53	42.0	298.0	7.0	-0.032	0.025	1000.0	-1000.0	-0.015	-1000.0
IL12-mediated signaling events	41.0	3626.0	87.0	-0.207	0.038	1000.0	-1000.0	-0.07	-1000.0
Glypican 1 network	40.0	1930.0	48.0	-0.077	0.047	1000.0	-1000.0	-0.029	-1000.0
BCR signaling pathway	40.0	4011.0	99.0	-0.131	0.029	1000.0	-1000.0	-0.039	-1000.0
amb2 Integrin signaling	37.0	3048.0	82.0	-0.082	0.034	1000.0	-1000.0	-0.036	-1000.0
Ephrin A  reverse signaling	36.0	258.0	7.0	-0.04	0.009	1000.0	-1000.0	-0.018	-1000.0
LPA receptor mediated events	36.0	3715.0	102.0	-0.068	0.031	1000.0	-1000.0	-0.06	-1000.0
EGFR-dependent Endothelin signaling events	36.0	762.0	21.0	-0.049	0.039	1000.0	-1000.0	-0.04	-1000.0
Syndecan-4-mediated signaling events	36.0	2415.0	67.0	-0.063	0.039	1000.0	-1000.0	-0.033	-1000.0
Syndecan-1-mediated signaling events	34.0	1179.0	34.0	-0.043	0.026	1000.0	-1000.0	-0.037	-1000.0
IL1-mediated signaling events	34.0	2139.0	62.0	-0.047	0.091	1000.0	-1000.0	-0.054	-1000.0
TCGA08_retinoblastoma	34.0	277.0	8.0	-0.007	0.029	1000.0	-1000.0	-0.006	-1000.0
Thromboxane A2 receptor signaling	33.0	3505.0	105.0	-0.081	0.035	1000.0	-1000.0	-0.046	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	32.0	1088.0	34.0	-0.036	0.048	1000.0	-1000.0	-0.027	-1000.0
p75(NTR)-mediated signaling	32.0	4002.0	125.0	-0.063	0.065	1000.0	-1000.0	-0.066	-1000.0
Glucocorticoid receptor regulatory network	31.0	3539.0	114.0	-0.226	0.123	1000.0	-1000.0	-0.051	-1000.0
Signaling events regulated by Ret tyrosine kinase	31.0	2596.0	82.0	-0.049	0.034	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	31.0	2471.0	78.0	-0.136	0.033	1000.0	-1000.0	-0.04	-1000.0
JNK signaling in the CD4+ TCR pathway	30.0	511.0	17.0	-0.043	0.029	1000.0	-1000.0	-0.029	-1000.0
EPHB forward signaling	30.0	2606.0	85.0	-0.047	0.081	1000.0	-1000.0	-0.057	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	30.0	2067.0	68.0	-0.163	0.06	1000.0	-1000.0	-0.07	-1000.0
PDGFR-beta signaling pathway	30.0	2931.0	97.0	-0.086	0.076	1000.0	-1000.0	-0.052	-1000.0
Effects of Botulinum toxin	29.0	769.0	26.0	-0.066	0.035	1000.0	-1000.0	-0.015	-1000.0
Calcium signaling in the CD4+ TCR pathway	29.0	914.0	31.0	-0.073	0.027	1000.0	-1000.0	-0.037	-1000.0
BMP receptor signaling	27.0	2243.0	81.0	-0.051	0.041	1000.0	-1000.0	-0.034	-1000.0
Angiopoietin receptor Tie2-mediated signaling	27.0	2454.0	88.0	-0.055	0.039	1000.0	-1000.0	-0.051	-1000.0
VEGFR1 specific signals	25.0	1446.0	56.0	-0.002	0.081	1000.0	-1000.0	-0.038	-1000.0
Visual signal transduction: Rods	25.0	1300.0	52.0	-0.049	0.041	1000.0	-1000.0	-0.028	-1000.0
Nongenotropic Androgen signaling	24.0	1275.0	52.0	-0.028	0.047	1000.0	-1000.0	-0.03	-1000.0
IGF1 pathway	24.0	1418.0	57.0	-0.038	0.052	1000.0	-1000.0	-0.038	-1000.0
Plasma membrane estrogen receptor signaling	24.0	2113.0	86.0	-0.034	0.076	1000.0	-1000.0	-0.044	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	24.0	2950.0	120.0	-0.079	0.072	1000.0	-1000.0	-0.039	-1000.0
Caspase cascade in apoptosis	23.0	1769.0	74.0	-0.056	0.053	1000.0	-1000.0	-0.037	-1000.0
Syndecan-2-mediated signaling events	23.0	1650.0	69.0	-0.027	0.039	1000.0	-1000.0	-0.034	-1000.0
IFN-gamma pathway	23.0	1573.0	68.0	-0.05	0.037	1000.0	-1000.0	-0.051	-1000.0
Retinoic acid receptors-mediated signaling	23.0	1375.0	58.0	-0.038	0.047	1000.0	-1000.0	-0.043	-1000.0
Integrins in angiogenesis	23.0	1950.0	84.0	-0.082	0.055	1000.0	-1000.0	-0.045	-1000.0
Cellular roles of Anthrax toxin	22.0	864.0	39.0	-0.029	0.025	1000.0	-1000.0	-0.021	-1000.0
Arf6 signaling events	22.0	1366.0	62.0	-0.05	0.058	1000.0	-1000.0	-0.03	-1000.0
Presenilin action in Notch and Wnt signaling	22.0	1342.0	61.0	-0.04	0.065	1000.0	-1000.0	-0.044	-1000.0
Ceramide signaling pathway	22.0	1702.0	76.0	-0.039	0.066	1000.0	-1000.0	-0.037	-1000.0
FAS signaling pathway (CD95)	22.0	1069.0	47.0	-0.125	0.041	1000.0	-1000.0	-0.025	-1000.0
Canonical Wnt signaling pathway	22.0	1146.0	51.0	-0.104	0.079	1000.0	-1000.0	-0.045	-1000.0
IL6-mediated signaling events	22.0	1659.0	75.0	-0.038	0.046	1000.0	-1000.0	-0.05	-1000.0
a4b1 and a4b7 Integrin signaling	21.0	106.0	5.0	0.006	0.024	1000.0	-1000.0	0.012	-1000.0
Ras signaling in the CD4+ TCR pathway	21.0	360.0	17.0	-0.018	0.039	1000.0	-1000.0	-0.025	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	20.0	1114.0	54.0	-0.045	0.035	1000.0	-1000.0	-0.038	-1000.0
Class I PI3K signaling events	20.0	1516.0	73.0	-0.063	0.03	1000.0	-1000.0	-0.038	-1000.0
ErbB2/ErbB3 signaling events	19.0	1296.0	65.0	-0.054	0.039	1000.0	-1000.0	-0.062	-1000.0
IL27-mediated signaling events	19.0	982.0	51.0	-0.108	0.027	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by PTP1B	18.0	1399.0	76.0	-0.049	0.044	1000.0	-1000.0	-0.033	-1000.0
S1P1 pathway	18.0	680.0	36.0	-0.055	0.038	1000.0	-1000.0	-0.033	-1000.0
Glypican 2 network	18.0	72.0	4.0	0.013	0.024	1000.0	-1000.0	0.012	-1000.0
FOXM1 transcription factor network	18.0	940.0	51.0	-0.111	0.046	1000.0	-1000.0	-0.111	-1000.0
S1P4 pathway	18.0	458.0	25.0	-0.016	0.036	1000.0	-1000.0	-0.022	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	17.0	659.0	37.0	-0.024	0.053	1000.0	-1000.0	-0.025	-1000.0
Visual signal transduction: Cones	16.0	632.0	38.0	-0.019	0.04	1000.0	-1000.0	-0.029	-1000.0
EPO signaling pathway	16.0	897.0	55.0	-0.016	0.06	1000.0	-1000.0	-0.035	-1000.0
PDGFR-alpha signaling pathway	16.0	709.0	44.0	-0.032	0.057	1000.0	-1000.0	-0.039	-1000.0
Regulation of p38-alpha and p38-beta	16.0	872.0	54.0	-0.065	0.05	1000.0	-1000.0	-0.044	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	15.0	1281.0	85.0	-0.056	0.046	1000.0	-1000.0	-0.039	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	15.0	810.0	52.0	-0.026	0.075	1000.0	-1000.0	-0.034	-1000.0
LPA4-mediated signaling events	14.0	170.0	12.0	-0.044	0.0	1000.0	-1000.0	-0.024	-1000.0
Syndecan-3-mediated signaling events	14.0	511.0	35.0	-0.017	0.065	1000.0	-1000.0	-0.023	-1000.0
Regulation of Androgen receptor activity	14.0	1028.0	70.0	-0.135	0.057	1000.0	-1000.0	-0.036	-1000.0
Aurora B signaling	14.0	991.0	67.0	-0.157	0.061	1000.0	-1000.0	-0.029	-1000.0
Coregulation of Androgen receptor activity	13.0	1062.0	76.0	-0.106	0.053	1000.0	-1000.0	-0.023	-1000.0
Class I PI3K signaling events mediated by Akt	13.0	892.0	68.0	-0.044	0.051	1000.0	-1000.0	-0.028	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	13.0	620.0	45.0	-0.035	0.068	1000.0	-1000.0	-0.041	-1000.0
IL2 signaling events mediated by STAT5	13.0	290.0	22.0	-0.03	0.027	1000.0	-1000.0	-0.043	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	13.0	435.0	33.0	-0.008	0.063	1000.0	-1000.0	-0.032	-1000.0
Arf6 downstream pathway	12.0	526.0	43.0	-0.029	0.039	1000.0	-1000.0	-0.03	-1000.0
mTOR signaling pathway	12.0	671.0	53.0	-0.072	0.029	1000.0	-1000.0	-0.028	-1000.0
Nectin adhesion pathway	12.0	816.0	63.0	-0.012	0.07	1000.0	-1000.0	-0.048	-1000.0
S1P5 pathway	12.0	204.0	17.0	-0.009	0.029	1000.0	-1000.0	-0.008	-1000.0
Paxillin-dependent events mediated by a4b1	12.0	432.0	36.0	-0.041	0.043	1000.0	-1000.0	-0.03	-1000.0
IL2 signaling events mediated by PI3K	12.0	723.0	58.0	-0.017	0.043	1000.0	-1000.0	-0.036	-1000.0
S1P3 pathway	12.0	504.0	42.0	-0.018	0.042	1000.0	-1000.0	-0.037	-1000.0
PLK1 signaling events	11.0	945.0	85.0	-0.008	0.057	1000.0	-1000.0	-0.022	-1000.0
Signaling mediated by p38-gamma and p38-delta	11.0	178.0	15.0	-0.021	0.024	1000.0	-1000.0	-0.027	-1000.0
Arf6 trafficking events	11.0	799.0	71.0	-0.042	0.045	1000.0	-1000.0	-0.027	-1000.0
Regulation of Telomerase	11.0	1166.0	102.0	-0.058	0.05	1000.0	-1000.0	-0.048	-1000.0
Insulin Pathway	11.0	815.0	74.0	-0.049	0.081	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by PRL	11.0	387.0	34.0	-0.021	0.076	1000.0	-1000.0	-0.04	-1000.0
Class IB PI3K non-lipid kinase events	11.0	33.0	3.0	-0.017	0.017	1000.0	-1000.0	-0.009	-1000.0
Sphingosine 1-phosphate (S1P) pathway	10.0	296.0	28.0	-0.024	0.041	1000.0	-1000.0	-0.027	-1000.0
Hedgehog signaling events mediated by Gli proteins	10.0	665.0	65.0	-0.019	0.046	1000.0	-1000.0	-0.035	-1000.0
Insulin-mediated glucose transport	10.0	335.0	32.0	-0.13	0.04	1000.0	-1000.0	-0.024	-1000.0
ceramide signaling pathway	10.0	511.0	49.0	-0.002	0.036	1000.0	-1000.0	-0.039	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	10.0	771.0	74.0	-0.053	0.061	1000.0	-1000.0	-0.056	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	10.0	293.0	27.0	-0.027	0.041	1000.0	-1000.0	-0.037	-1000.0
Regulation of nuclear SMAD2/3 signaling	9.0	1344.0	136.0	-0.055	0.05	1000.0	-1000.0	-0.034	-1000.0
ErbB4 signaling events	9.0	662.0	69.0	-0.074	0.05	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by HDAC Class III	9.0	378.0	40.0	-0.045	0.048	1000.0	-1000.0	-0.029	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	9.0	817.0	83.0	-0.048	0.055	1000.0	-1000.0	-0.033	-1000.0
TCGA08_rtk_signaling	9.0	254.0	26.0	-0.025	0.058	1000.0	-1000.0	-0.004	-1000.0
HIF-2-alpha transcription factor network	8.0	345.0	43.0	-0.083	0.085	1000.0	-1000.0	-0.04	-1000.0
FoxO family signaling	8.0	513.0	64.0	-0.064	0.062	1000.0	-1000.0	-0.053	-1000.0
E-cadherin signaling in the nascent adherens junction	8.0	619.0	76.0	-0.013	0.08	1000.0	-1000.0	-0.052	-1000.0
BARD1 signaling events	7.0	434.0	57.0	-0.028	0.065	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by HDAC Class I	7.0	730.0	104.0	-0.051	0.062	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	7.0	955.0	125.0	-0.021	0.095	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by HDAC Class II	6.0	472.0	75.0	-0.023	0.07	1000.0	-1000.0	-0.031	-1000.0
Canonical NF-kappaB pathway	5.0	214.0	39.0	-0.009	0.056	1000.0	-1000.0	-0.031	-1000.0
p38 MAPK signaling pathway	5.0	221.0	44.0	-0.008	0.058	1000.0	-1000.0	-0.022	-1000.0
Arf1 pathway	5.0	319.0	54.0	-0.004	0.04	1000.0	-1000.0	-0.015	-1000.0
Aurora C signaling	4.0	33.0	7.0	-0.0	0.033	1000.0	-1000.0	-0.015	-1000.0
PLK2 and PLK4 events	3.0	9.0	3.0	-0.015	-1000.0	1000.0	-1000.0	-0.024	-1000.0
Atypical NF-kappaB pathway	3.0	106.0	31.0	-0.01	0.048	1000.0	-1000.0	-0.025	-1000.0
Rapid glucocorticoid signaling	3.0	64.0	20.0	-0.015	0.03	1000.0	-1000.0	-0.015	-1000.0
E-cadherin signaling in keratinocytes	3.0	156.0	43.0	-0.039	0.08	1000.0	-1000.0	-0.029	-1000.0
Aurora A signaling	2.0	169.0	60.0	-0.014	0.07	1000.0	-1000.0	-0.026	-1000.0
TRAIL signaling pathway	2.0	112.0	48.0	-0.014	0.056	1000.0	-1000.0	-0.031	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	27.0	23.0	0.012	0.037	1000.0	-1000.0	-0.024	-1000.0
Circadian rhythm pathway	1.0	27.0	22.0	-0.006	0.058	1000.0	-1000.0	-0.044	-1000.0
E-cadherin signaling events	1.0	5.0	5.0	0.025	0.051	1000.0	-1000.0	0.006	-1000.0
Alternative NF-kappaB pathway	1.0	21.0	13.0	0.0	0.07	1000.0	-1000.0	0.0	-1000.0
Total	2821	168776	7203	-7.85017853594	-993.361865489	131000	-131000	-4.80244980484	-131000