E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.006 0.143 -9999.0 0.0 -0.491 16.0 16.0 KLHL20 0.031 0.119 0.224 14.0 -0.247 18.0 32.0 CYFIP2 0.012 0.108 -9999.0 0.0 -0.444 11.0 11.0 Rac1/GDP 0.046 0.139 0.296 5.0 -0.413 7.0 12.0 ENAH -0.016 0.149 -9999.0 0.0 -0.504 16.0 16.0 AP1M1 0.035 0.035 -9999.0 0.0 -0.469 1.0 1.0 RAP1B 0.035 0.035 -9999.0 0.0 -0.469 1.0 1.0 RAP1A 0.035 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.018 0.081 -9999.0 0.0 -0.274 13.0 13.0 CDC42/GTP 0.039 0.101 -9999.0 0.0 -0.362 6.0 6.0 ABI1/Sra1/Nap1 -0.028 0.058 -9999.0 0.0 -0.18 21.0 21.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.021 0.122 -9999.0 0.0 -0.264 28.0 28.0 RAPGEF1 0.035 0.154 0.337 3.0 -0.49 11.0 14.0 CTNND1 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.002 0.148 -9999.0 0.0 -0.503 16.0 16.0 CRK 0.032 0.158 -9999.0 0.0 -0.533 11.0 11.0 E-cadherin/gamma catenin/alpha catenin 0.054 0.079 -9999.0 0.0 -0.288 10.0 10.0 alphaE/beta7 Integrin 0.017 0.097 -9999.0 0.0 -0.334 14.0 14.0 IQGAP1 0.035 0.01 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.025 0.064 -9999.0 0.0 -0.243 10.0 10.0 Rap1/GTP/I-afadin 0.056 0.059 -9999.0 0.0 -0.261 6.0 6.0 DLG1 -0.008 0.143 -9999.0 0.0 -0.491 16.0 16.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.01 0.055 -9999.0 0.0 -0.268 6.0 6.0 MLLT4 0.024 0.077 -9999.0 0.0 -0.469 5.0 5.0 ARF6/GTP/NME1/Tiam1 0.05 0.059 -9999.0 0.0 -0.272 5.0 5.0 PI3K -0.01 0.074 -9999.0 0.0 -0.357 6.0 6.0 ARF6 0.029 0.05 -9999.0 0.0 -0.469 2.0 2.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.033 0.084 -9999.0 0.0 -0.338 10.0 10.0 TIAM1 0.03 0.051 -9999.0 0.0 -0.375 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.055 0.09 -9999.0 0.0 -0.252 14.0 14.0 AKT1 0.028 0.068 0.193 4.0 -0.203 5.0 9.0 PIK3R1 0.03 0.06 -9999.0 0.0 -0.469 3.0 3.0 CDH1 0.013 0.107 -9999.0 0.0 -0.469 10.0 10.0 RhoA/GDP 0.063 0.145 0.33 6.0 -0.412 7.0 13.0 actin cytoskeleton organization 0.032 0.097 0.206 17.0 -0.179 18.0 35.0 CDC42/GDP 0.059 0.146 0.327 7.0 -0.411 7.0 14.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.016 0.055 -9999.0 0.0 -0.228 10.0 10.0 ITGB7 0.004 0.125 -9999.0 0.0 -0.469 14.0 14.0 RAC1 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.06 0.097 -9999.0 0.0 -0.268 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.037 0.083 -9999.0 0.0 -0.25 14.0 14.0 mol:GDP 0.048 0.158 0.33 7.0 -0.423 11.0 18.0 CDC42/GTP/IQGAP1 0.043 0.02 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.035 0.017 -9999.0 0.0 -0.187 1.0 1.0 p120 catenin/RhoA/GDP 0.072 0.151 0.337 6.0 -0.423 7.0 13.0 RAC1/GTP/IQGAP1 0.042 0.019 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.052 0.028 -9999.0 0.0 -0.338 1.0 1.0 RHOA 0.037 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.034 0.018 -9999.0 0.0 -0.187 1.0 1.0 CTNNA1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.03 0.077 0.169 20.0 -0.18 4.0 24.0 NME1 0.033 0.035 -9999.0 0.0 -0.469 1.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.009 0.143 -9999.0 0.0 -0.491 16.0 16.0 regulation of cell-cell adhesion -0.002 0.067 -9999.0 0.0 -0.313 6.0 6.0 WASF2 0.012 0.053 0.111 13.0 -0.144 3.0 16.0 Rap1/GTP 0.07 0.126 0.323 3.0 -0.413 6.0 9.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.045 0.115 -9999.0 0.0 -0.248 23.0 23.0 CCND1 0.033 0.09 0.192 20.0 -0.208 5.0 25.0 VAV2 0.005 0.286 0.416 1.0 -0.719 23.0 24.0 RAP1/GDP 0.072 0.138 0.345 4.0 -0.425 6.0 10.0 adherens junction assembly -0.009 0.138 -9999.0 0.0 -0.474 16.0 16.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.018 0.112 -9999.0 0.0 -0.245 23.0 23.0 E-cadherin/beta catenin -0.002 0.079 -9999.0 0.0 -0.33 11.0 11.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.018 0.138 -9999.0 0.0 -0.569 11.0 11.0 PIK3CA 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.042 0.133 -9999.0 0.0 -0.391 23.0 23.0 E-cadherin/beta catenin/alpha catenin 0.042 0.097 -9999.0 0.0 -0.294 14.0 14.0 ITGAE 0.028 0.026 -9999.0 0.0 -0.187 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.001 0.152 -9999.0 0.0 -0.515 16.0 16.0