Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.009 0.155 -9999.0 0.0 -0.661 9.0 9.0 IHH 0.024 0.102 -9999.0 0.0 -0.387 9.0 9.0 SHH Np/Cholesterol/GAS1 -0.071 0.136 -9999.0 0.0 -0.297 47.0 47.0 LRPAP1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.071 0.135 0.295 47.0 -9999.0 0.0 47.0 SMO/beta Arrestin2 0.001 0.157 -9999.0 0.0 -0.523 11.0 11.0 SMO -0.012 0.156 -9999.0 0.0 -0.533 12.0 12.0 AKT1 -0.014 0.162 -9999.0 0.0 -0.421 21.0 21.0 ARRB2 0.027 0.037 -9999.0 0.0 -0.469 1.0 1.0 BOC 0.028 0.05 -9999.0 0.0 -0.227 7.0 7.0 ADRBK1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.011 0.153 -9999.0 0.0 -0.523 12.0 12.0 STIL -0.005 0.127 0.365 1.0 -0.39 10.0 11.0 DHH N/PTCH2 0.054 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.033 0.12 -9999.0 0.0 -0.389 13.0 13.0 PIK3CA 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.005 0.205 -9999.0 0.0 -0.913 9.0 9.0 determination of left/right symmetry -0.011 0.153 -9999.0 0.0 -0.523 12.0 12.0 PIK3R1 0.03 0.06 -9999.0 0.0 -0.469 3.0 3.0 skeletal system development -0.004 0.202 -9999.0 0.0 -0.9 9.0 9.0 IHH N/Hhip -0.014 0.161 -9999.0 0.0 -0.397 29.0 29.0 DHH N/Hhip -0.003 0.131 -9999.0 0.0 -0.338 26.0 26.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.011 0.153 -9999.0 0.0 -0.523 12.0 12.0 pancreas development -0.036 0.168 -9999.0 0.0 -0.385 37.0 37.0 HHAT 0.0 0.124 -9999.0 0.0 -0.391 18.0 18.0 PI3K 0.048 0.047 -9999.0 0.0 -0.338 3.0 3.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.114 0.197 -9999.0 0.0 -0.316 92.0 92.0 somite specification -0.011 0.153 -9999.0 0.0 -0.523 12.0 12.0 SHH Np/Cholesterol/PTCH1 -0.001 0.121 -9999.0 0.0 -0.384 11.0 11.0 SHH Np/Cholesterol/PTCH2 0.011 0.078 -9999.0 0.0 -0.266 14.0 14.0 SHH Np/Cholesterol/Megalin 0.01 0.078 -9999.0 0.0 -0.266 14.0 14.0 SHH -0.009 0.092 -9999.0 0.0 -0.345 14.0 14.0 catabolic process 0.014 0.126 -9999.0 0.0 -0.43 13.0 13.0 SMO/Vitamin D3 -0.011 0.144 -9999.0 0.0 -0.413 16.0 16.0 SHH Np/Cholesterol/Hhip -0.029 0.127 -9999.0 0.0 -0.296 35.0 35.0 LRP2 0.035 0.022 -9999.0 0.0 -0.187 2.0 2.0 receptor-mediated endocytosis -0.016 0.142 -9999.0 0.0 -0.478 11.0 11.0 SHH Np/Cholesterol/BOC 0.007 0.08 -9999.0 0.0 -0.266 14.0 14.0 SHH Np/Cholesterol/CDO 0.01 0.078 -9999.0 0.0 -0.266 14.0 14.0 mesenchymal cell differentiation 0.029 0.126 0.294 35.0 -9999.0 0.0 35.0 mol:Vitamin D3 0.007 0.131 0.387 1.0 -0.386 11.0 12.0 IHH N/PTCH2 0.045 0.067 -9999.0 0.0 -0.343 5.0 5.0 CDON 0.034 0.022 -9999.0 0.0 -0.187 2.0 2.0 IHH N/PTCH1 0.026 0.13 -9999.0 0.0 -0.434 13.0 13.0 Megalin/LRPAP1 0.052 0.02 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.037 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.002 0.073 -9999.0 0.0 -0.264 14.0 14.0 PTCH1 0.014 0.126 -9999.0 0.0 -0.432 13.0 13.0 HHIP -0.036 0.168 -9999.0 0.0 -0.385 37.0 37.0