Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.01 0.075 -9999.0 0.0 -0.229 17.0 17.0 epithelial cell differentiation 0.048 0.087 -9999.0 0.0 -0.249 14.0 14.0 CYFIP2 0.012 0.108 -9999.0 0.0 -0.444 11.0 11.0 ENAH -0.04 0.082 0.278 1.0 -0.369 4.0 5.0 EGFR 0.018 0.086 -9999.0 0.0 -0.399 8.0 8.0 EPHA2 0.014 0.083 -9999.0 0.0 -0.262 15.0 15.0 MYO6 -0.007 0.074 -9999.0 0.0 -0.242 17.0 17.0 CTNNB1 0.018 0.081 -9999.0 0.0 -0.274 13.0 13.0 ABI1/Sra1/Nap1 0.048 0.088 -9999.0 0.0 -0.296 11.0 11.0 AQP5 -0.005 0.093 -9999.0 0.0 -0.489 4.0 4.0 CTNND1 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.001 0.069 -9999.0 0.0 -0.238 14.0 14.0 regulation of calcium-dependent cell-cell adhesion -0.035 0.094 -9999.0 0.0 -0.24 32.0 32.0 EGF -0.087 0.183 -9999.0 0.0 -0.303 78.0 78.0 NCKAP1 0.025 0.064 -9999.0 0.0 -0.243 10.0 10.0 AQP3 -0.02 0.111 -9999.0 0.0 -0.453 8.0 8.0 cortical microtubule organization 0.048 0.087 -9999.0 0.0 -0.249 14.0 14.0 GO:0000145 -0.025 0.059 -9999.0 0.0 -0.229 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.055 0.09 -9999.0 0.0 -0.252 14.0 14.0 MLLT4 0.024 0.077 -9999.0 0.0 -0.469 5.0 5.0 ARF6/GDP -0.05 0.085 -9999.0 0.0 -0.386 6.0 6.0 ARF6 0.029 0.05 -9999.0 0.0 -0.469 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.049 0.097 -9999.0 0.0 -0.276 12.0 12.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.015 0.07 -9999.0 0.0 -0.311 3.0 3.0 PVRL2 0.032 0.041 -9999.0 0.0 -0.281 3.0 3.0 ZYX -0.006 0.07 -9999.0 0.0 -0.241 15.0 15.0 ARF6/GTP 0.048 0.103 -9999.0 0.0 -0.265 14.0 14.0 CDH1 0.013 0.107 -9999.0 0.0 -0.469 10.0 10.0 EGFR/EGFR/EGF/EGF -0.036 0.134 -9999.0 0.0 -0.263 42.0 42.0 RhoA/GDP 0.051 0.085 -9999.0 0.0 -0.239 14.0 14.0 actin cytoskeleton organization -0.03 0.063 -9999.0 0.0 -0.301 1.0 1.0 IGF-1R heterotetramer 0.032 0.039 -9999.0 0.0 -0.327 2.0 2.0 GIT1 0.035 0.017 -9999.0 0.0 -0.187 1.0 1.0 IGF1R 0.032 0.039 -9999.0 0.0 -0.328 2.0 2.0 IGF1 0.018 0.078 -9999.0 0.0 -0.243 15.0 15.0 DIAPH1 0.029 0.18 -9999.0 0.0 -0.62 14.0 14.0 Wnt receptor signaling pathway -0.048 0.087 0.249 14.0 -9999.0 0.0 14.0 RHOA 0.037 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.048 0.082 -9999.0 0.0 -0.387 6.0 6.0 CTNNA1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.031 0.064 -9999.0 0.0 -0.307 1.0 1.0 EFNA1 0.024 0.073 -9999.0 0.0 -0.348 7.0 7.0 LPP -0.026 0.061 -9999.0 0.0 -0.296 1.0 1.0 Ephrin A1/EPHA2 0.021 0.113 -9999.0 0.0 -0.303 16.0 16.0 SEC6/SEC8 -0.008 0.085 -9999.0 0.0 -0.361 7.0 7.0 MGAT3 -0.035 0.096 -9999.0 0.0 -0.243 32.0 32.0 HGF/MET 0.037 0.092 -9999.0 0.0 -0.257 14.0 14.0 HGF 0.034 0.023 -9999.0 0.0 -0.187 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.01 0.075 -9999.0 0.0 -0.231 17.0 17.0 actin cable formation -0.018 0.101 0.356 4.0 -0.298 7.0 11.0 KIAA1543 -0.025 0.06 -9999.0 0.0 -0.232 13.0 13.0 KIFC3 -0.006 0.07 -9999.0 0.0 -0.241 15.0 15.0 NCK1 0.028 0.069 -9999.0 0.0 -0.469 4.0 4.0 EXOC3 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.002 0.069 -9999.0 0.0 -0.241 14.0 14.0 NCK1/GIT1 0.044 0.056 -9999.0 0.0 -0.338 4.0 4.0 mol:GDP 0.048 0.087 -9999.0 0.0 -0.249 14.0 14.0 EXOC4 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.004 0.068 -9999.0 0.0 -0.241 15.0 15.0 PIP5K1C -0.001 0.07 -9999.0 0.0 -0.241 14.0 14.0 LIMA1 0.026 0.072 -9999.0 0.0 -0.375 6.0 6.0 ABI1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.031 0.09 0.3 3.0 -0.386 4.0 7.0 adherens junction assembly -0.007 0.072 0.282 2.0 -0.315 1.0 3.0 IGF-1R heterotetramer/IGF1 0.027 0.095 -9999.0 0.0 -0.245 16.0 16.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.04 0.068 -9999.0 0.0 -0.338 6.0 6.0 MET 0.029 0.053 -9999.0 0.0 -0.328 4.0 4.0 PLEKHA7 -0.001 0.07 -9999.0 0.0 -0.243 13.0 13.0 mol:GTP 0.047 0.095 -9999.0 0.0 -0.275 12.0 12.0 establishment of epithelial cell apical/basal polarity -0.025 0.094 0.328 1.0 -0.41 4.0 5.0 cortical actin cytoskeleton stabilization 0.01 0.075 -9999.0 0.0 -0.229 17.0 17.0 regulation of cell-cell adhesion -0.03 0.063 -9999.0 0.0 -0.301 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.01 0.075 -9999.0 0.0 -0.231 17.0 17.0