Clinical Features	CN_CNMF		METHLYATION_CNMF		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nCNV (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
1p gain	10 (14%)	63	0.90482	1	0.61571	1	0.36514	1	0.39391	1	0.0074569	1	0.39391	1
1q gain	25 (34%)	48	0.66783	1	0.24596	1	0.077475	1	0.030887	1	0.019333	1	0.030887	1
2p gain	29 (40%)	44	0.15956	1	0.38854	1	0.11592	1	0.68896	1	0.0092751	1	0.68896	1
2q gain	18 (25%)	55	0.72831	1	0.55701	1	0.67325	1	0.68841	1	0.064666	1	0.68841	1
3p gain	11 (15%)	62	0.06386	1	0.21953	1	0.10078	1	0.30627	1	0.053343	1	0.30627	1
3q gain	33 (45%)	40	3.615e-05	0.0174	0.0016423	0.777	0.0047874	1	0.0068749	1	0.051695	1	0.0068749	1
4p gain	6 (8%)	67	0.85447	1	1	1	0.73479	1	1	1	1	1	1	1
4q gain	5 (7%)	68	0.10099	1	0.84537	1	0.41184	1	0.66659	1	0.79095	1	0.66659	1
5p gain	33 (45%)	40	0.55694	1	0.73205	1	0.29275	1	0.37527	1	0.35991	1	0.37527	1
5q gain	10 (14%)	63	0.82155	1	0.82155	1	0.74936	1	0.57034	1	1	1	0.57034	1
6p gain	9 (12%)	64	0.81146	1	0.89848	1	0.90401	1	0.76535	1	0.67868	1	0.76535	1
6q gain	8 (11%)	65	0.30905	1	0.38938	1	1	1	1	1	1	1	1	1
7p gain	47 (64%)	26	0.62782	1	1	1	0.88302	1	0.54143	1	0.71732	1	0.54143	1
7q gain	34 (47%)	39	0.17963	1	0.61165	1	0.52744	1	0.37527	1	0.35827	1	0.37527	1
8p gain	29 (40%)	44	0.15617	1	0.24141	1	0.93237	1	1	1	0.96815	1	1	1
8q gain	41 (56%)	32	0.11779	1	0.25924	1	0.66876	1	0.32113	1	0.66682	1	0.32113	1
9p gain	7 (10%)	66	0.042347	1	0.51933	1	0.41883	1	0.44266	1	0.38983	1	0.44266	1
9q gain	17 (23%)	56	0.051204	1	0.52046	1	0.43853	1	0.58032	1	0.64898	1	0.58032	1
10p gain	14 (19%)	59	0.46024	1	0.38472	1	0.090169	1	0.76442	1	0.21657	1	0.76442	1
10q gain	9 (12%)	64	0.33517	1	0.5235	1	0.13237	1	0.52542	1	0.094041	1	0.52542	1
11p gain	15 (21%)	58	0.28479	1	1	1	0.51301	1	0.47971	1	0.51775	1	0.47971	1
11q gain	13 (18%)	60	0.7231	1	0.61889	1	0.20591	1	0.19758	1	0.45088	1	0.19758	1
12p gain	31 (42%)	42	0.0076144	1	0.013702	1	0.012306	1	0.0047872	1	0.065558	1	0.0047872	1
12q gain	18 (25%)	55	0.1307	1	0.051645	1	0.23896	1	0.33568	1	0.50957	1	0.33568	1
13q gain	15 (21%)	58	0.00053075	0.254	0.0041274	1	0.0013949	0.661	0.00059509	0.284	0.002043	0.96	0.00059509	0.284
14q gain	22 (30%)	51	0.43735	1	0.3878	1	0.46865	1	0.45687	1	0.23803	1	0.45687	1
15q gain	12 (16%)	61	0.77767	1	0.091032	1	0.18845	1	0.6006	1	0.76843	1	0.6006	1
16p gain	16 (22%)	57	0.90348	1	0.13362	1	0.15758	1	0.10492	1	0.11139	1	0.10492	1
16q gain	13 (18%)	60	0.24711	1	0.083659	1	0.074898	1	0.10356	1	0.029681	1	0.10356	1
17p gain	15 (21%)	58	0.088154	1	0.19768	1	0.75931	1	1	1	0.85275	1	1	1
17q gain	21 (29%)	52	0.8982	1	0.67658	1	0.35158	1	0.45953	1	0.74937	1	0.45953	1
18p gain	24 (33%)	49	0.044209	1	0.26824	1	0.44706	1	0.51733	1	0.40455	1	0.51733	1
18q gain	9 (12%)	64	0.33517	1	0.65226	1	0.81171	1	0.76535	1	0.95637	1	0.76535	1
19p gain	11 (15%)	62	0.0059752	1	0.91276	1	0.74936	1	0.57034	1	0.34132	1	0.57034	1
19q gain	15 (21%)	58	0.0017383	0.82	0.19964	1	0.053595	1	0.030142	1	0.026601	1	0.030142	1
20p gain	39 (53%)	34	0.85245	1	0.74633	1	0.65814	1	0.61524	1	0.69985	1	0.61524	1
20q gain	42 (58%)	31	0.24565	1	0.10031	1	0.12035	1	0.051623	1	0.33498	1	0.051623	1
21q gain	8 (11%)	65	0.79527	1	0.70067	1	0.77515	1	0.72555	1	0.1081	1	0.72555	1
22q gain	17 (23%)	56	0.010829	1	0.0024575	1	0.0020248	0.954	0.0010955	0.521	0.0096566	1	0.0010955	0.521
xq gain	17 (23%)	56	0.25999	1	0.32258	1	0.44454	1	0.36971	1	0.62284	1	0.36971	1
1p loss	13 (18%)	60	0.52859	1	0.61889	1	0.36244	1	0.37418	1	0.91622	1	0.37418	1
1q loss	11 (15%)	62	0.013049	1	0.57901	1	0.1584	1	0.42626	1	0.96283	1	0.42626	1
2p loss	3 (4%)	70	1	1	0.13777	1	0.79577	1	1	1	0.86377	1	1	1
2q loss	9 (12%)	64	0.7284	1	0.01866	1	0.13138	1	0.19354	1	0.21849	1	0.19354	1
3p loss	43 (59%)	30	0.14142	1	0.29517	1	0.1843	1	0.040024	1	0.18078	1	0.040024	1
3q loss	13 (18%)	60	0.78548	1	0.7231	1	0.17898	1	0.3402	1	0.67588	1	0.3402	1
4p loss	42 (58%)	31	0.14034	1	0.6646	1	0.4462	1	0.16366	1	0.6982	1	0.16366	1
4q loss	35 (48%)	38	0.0024362	1	0.67675	1	0.79375	1	0.83586	1	0.96915	1	0.83586	1
5p loss	18 (25%)	55	0.21712	1	0.38182	1	0.10647	1	0.11704	1	0.0090751	1	0.11704	1
5q loss	32 (44%)	41	1	1	0.58141	1	0.66876	1	0.71863	1	0.29425	1	0.71863	1
6p loss	18 (25%)	55	0.10064	1	0.51859	1	0.40135	1	0.43931	1	0.39091	1	0.43931	1
6q loss	16 (22%)	57	0.19637	1	0.40668	1	0.44454	1	0.36971	1	0.60747	1	0.36971	1
7p loss	6 (8%)	67	0.39706	1	0.28347	1	0.55389	1	0.44266	1	0.061829	1	0.44266	1
7q loss	10 (14%)	63	0.014591	1	0.44915	1	1	1	1	1	0.80139	1	1	1
8p loss	27 (37%)	46	0.25768	1	0.60467	1	0.71718	1	0.63394	1	0.69039	1	0.63394	1
8q loss	10 (14%)	63	0.24539	1	0.90482	1	0.67904	1	0.57034	1	0.3045	1	0.57034	1
9p loss	42 (58%)	31	0.06944	1	0.41377	1	0.67466	1	0.53396	1	0.91132	1	0.53396	1
9q loss	23 (32%)	50	0.01472	1	0.25241	1	0.44706	1	0.51733	1	0.16533	1	0.51733	1
10p loss	22 (30%)	51	0.33902	1	0.37429	1	0.61797	1	0.57472	1	0.84079	1	0.57472	1
10q loss	26 (36%)	47	0.012278	1	0.01724	1	0.097649	1	0.043838	1	0.12362	1	0.043838	1
11p loss	22 (30%)	51	0.013119	1	0.37429	1	0.32189	1	0.29342	1	0.41839	1	0.29342	1
11q loss	27 (37%)	46	0.014012	1	0.33544	1	0.23969	1	0.14553	1	0.24451	1	0.14553	1
12p loss	15 (21%)	58	0.021656	1	0.054006	1	0.0053797	1	0.0050423	1	0.076865	1	0.0050423	1
12q loss	15 (21%)	58	0.15745	1	0.054006	1	0.053595	1	0.030142	1	0.17095	1	0.030142	1
13q loss	31 (42%)	42	0.044485	1	0.094614	1	0.040736	1	0.012303	1	0.0080594	1	0.012303	1
14q loss	18 (25%)	55	0.37776	1	0.13366	1	0.039494	1	0.20989	1	0.02834	1	0.20989	1
15q loss	20 (27%)	53	0.92334	1	0.34959	1	0.52913	1	0.45953	1	0.65458	1	0.45953	1
16p loss	18 (25%)	55	0.37776	1	0.2176	1	0.12728	1	0.11704	1	0.13785	1	0.11704	1
16q loss	19 (26%)	54	0.032582	1	0.29852	1	0.062074	1	0.053354	1	0.13267	1	0.053354	1
17p loss	26 (36%)	47	0.054367	1	0.012278	1	0.05256	1	0.02386	1	0.033359	1	0.02386	1
17q loss	8 (11%)	65	0.61497	1	0.48811	1	0.15181	1	0.23155	1	0.094041	1	0.23155	1
18p loss	25 (34%)	48	0.27124	1	0.12165	1	0.071671	1	0.52647	1	0.089267	1	0.52647	1
18q loss	40 (55%)	33	0.45482	1	0.34951	1	0.21564	1	0.23808	1	0.11708	1	0.23808	1
19p loss	26 (36%)	47	0.012278	1	0.1539	1	0.02574	1	0.42576	1	0.046948	1	0.42576	1
19q loss	21 (29%)	52	0.024076	1	0.029019	1	0.025816	1	0.13659	1	0.19754	1	0.13659	1
20p loss	9 (12%)	64	0.81146	1	1	1	0.26664	1	0.39067	1	0.39825	1	0.39067	1
20q loss	3 (4%)	70	0.43585	1	0.13777	1	0.59859	1	0.57606	1	1	1	0.57606	1
21q loss	44 (60%)	29	0.47171	1	0.072372	1	0.14995	1	0.052405	1	0.085737	1	0.052405	1
22q loss	26 (36%)	47	0.42195	1	0.039371	1	0.28692	1	0.2436	1	0.37546	1	0.2436	1
xq loss	19 (26%)	54	0.41285	1	0.047954	1	0.33411	1	0.38907	1	0.3978	1	0.38907	1