E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.046 0.161 -9999.0 0.0 -0.402 24.0 24.0 KLHL20 0.021 0.098 0.181 11.0 -0.238 3.0 14.0 CYFIP2 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.018 0.104 -9999.0 0.0 -0.261 19.0 19.0 ENAH -0.044 0.158 -9999.0 0.0 -0.396 24.0 24.0 AP1M1 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.033 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.006 0.085 -9999.0 0.0 -0.311 1.0 1.0 ABI1/Sra1/Nap1 -0.02 0.044 -9999.0 0.0 -0.163 3.0 3.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.026 0.114 -9999.0 0.0 -0.226 24.0 24.0 RAPGEF1 -0.039 0.149 -9999.0 0.0 -0.378 21.0 21.0 CTNND1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.038 0.167 -9999.0 0.0 -0.41 24.0 24.0 CRK -0.042 0.155 -9999.0 0.0 -0.383 23.0 23.0 E-cadherin/gamma catenin/alpha catenin 0.007 0.115 -9999.0 0.0 -0.246 24.0 24.0 alphaE/beta7 Integrin 0.04 0.041 -9999.0 0.0 -0.277 2.0 2.0 IQGAP1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.052 0.024 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.047 0.16 -9999.0 0.0 -0.402 24.0 24.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.035 0.047 -9999.0 0.0 -0.224 1.0 1.0 MLLT4 0.029 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.057 0.02 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.043 0.061 -9999.0 0.0 -0.291 1.0 1.0 ARF6 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.013 0.124 -9999.0 0.0 -0.289 24.0 24.0 TIAM1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.028 0.104 -9999.0 0.0 -0.21 23.0 23.0 AKT1 -0.017 0.053 0.149 1.0 -0.169 1.0 2.0 PIK3R1 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.041 0.157 -9999.0 0.0 -0.401 23.0 23.0 RhoA/GDP -0.014 0.117 -9999.0 0.0 -0.26 21.0 21.0 actin cytoskeleton organization 0.019 0.077 0.15 11.0 -0.172 3.0 14.0 CDC42/GDP -0.014 0.117 -9999.0 0.0 -0.26 21.0 21.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.02 0.088 -9999.0 0.0 -0.212 25.0 25.0 ITGB7 0.025 0.051 -9999.0 0.0 -0.402 2.0 2.0 RAC1 0.022 0.015 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.03 0.112 -9999.0 0.0 -0.225 23.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.009 0.096 -9999.0 0.0 -0.206 23.0 23.0 mol:GDP -0.031 0.124 -9999.0 0.0 -0.295 21.0 21.0 CDC42/GTP/IQGAP1 0.043 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.029 0.037 -9999.0 0.0 -0.402 1.0 1.0 p120 catenin/RhoA/GDP -0.003 0.124 -9999.0 0.0 -0.267 21.0 21.0 RAC1/GTP/IQGAP1 0.029 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.044 0.029 -9999.0 0.0 -0.287 1.0 1.0 RHOA 0.033 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.015 0.054 0.113 10.0 -0.11 3.0 13.0 NME1 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.044 0.16 -9999.0 0.0 -0.409 23.0 23.0 regulation of cell-cell adhesion -0.015 0.067 -9999.0 0.0 -0.171 20.0 20.0 WASF2 0.006 0.04 0.089 2.0 -0.097 2.0 4.0 Rap1/GTP -0.005 0.095 -9999.0 0.0 -0.347 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.036 0.118 -9999.0 0.0 -0.217 25.0 25.0 CCND1 0.017 0.063 0.13 10.0 -0.133 3.0 13.0 VAV2 -0.05 0.213 -9999.0 0.0 -0.459 27.0 27.0 RAP1/GDP -0.002 0.103 -9999.0 0.0 -0.389 1.0 1.0 adherens junction assembly -0.043 0.155 -9999.0 0.0 -0.396 23.0 23.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.023 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.028 0.036 -9999.0 0.0 -0.402 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.011 0.106 -9999.0 0.0 -0.212 25.0 25.0 E-cadherin/beta catenin -0.044 0.114 -9999.0 0.0 -0.304 23.0 23.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.046 0.157 -9999.0 0.0 -0.401 23.0 23.0 PIK3CA 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.034 0.099 -9999.0 0.0 -0.291 8.0 8.0 E-cadherin/beta catenin/alpha catenin 0.009 0.113 -9999.0 0.0 -0.244 23.0 23.0 ITGAE 0.031 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.039 0.171 -9999.0 0.0 -0.418 24.0 24.0