Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.004 0.127 -9999.0 0.0 -0.487 9.0 9.0 IHH 0.021 0.051 -9999.0 0.0 -0.168 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.012 0.075 -9999.0 0.0 -0.237 13.0 13.0 LRPAP1 0.033 0.003 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.012 0.075 0.236 13.0 -9999.0 0.0 13.0 SMO/beta Arrestin2 0.046 0.118 -9999.0 0.0 -0.465 4.0 4.0 SMO -0.005 0.093 -9999.0 0.0 -0.483 4.0 4.0 AKT1 -0.005 0.102 -9999.0 0.0 -0.375 8.0 8.0 ARRB2 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.028 0.037 -9999.0 0.0 -0.402 1.0 1.0 ADRBK1 0.033 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.004 0.091 -9999.0 0.0 -0.476 4.0 4.0 STIL 0.015 0.121 0.18 29.0 -0.316 7.0 36.0 DHH N/PTCH2 0.021 0.079 -9999.0 0.0 -0.29 8.0 8.0 DHH N/PTCH1 0.009 0.107 -9999.0 0.0 -0.311 13.0 13.0 PIK3CA 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.014 0.073 -9999.0 0.0 -0.402 4.0 4.0 PTHLH -0.014 0.155 -9999.0 0.0 -0.611 8.0 8.0 determination of left/right symmetry -0.004 0.091 -9999.0 0.0 -0.476 4.0 4.0 PIK3R1 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.014 0.153 -9999.0 0.0 -0.605 8.0 8.0 IHH N/Hhip -0.015 0.124 -9999.0 0.0 -0.328 18.0 18.0 DHH N/Hhip -0.014 0.12 -9999.0 0.0 -0.3 20.0 20.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.004 0.091 -9999.0 0.0 -0.476 4.0 4.0 pancreas development -0.032 0.141 -9999.0 0.0 -0.401 18.0 18.0 HHAT 0.026 0.051 -9999.0 0.0 -0.402 2.0 2.0 PI3K 0.045 0.014 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.011 0.074 -9999.0 0.0 -0.402 4.0 4.0 somite specification -0.004 0.091 -9999.0 0.0 -0.476 4.0 4.0 SHH Np/Cholesterol/PTCH1 -0.018 0.091 -9999.0 0.0 -0.327 7.0 7.0 SHH Np/Cholesterol/PTCH2 -0.008 0.071 -9999.0 0.0 -0.238 11.0 11.0 SHH Np/Cholesterol/Megalin -0.038 0.103 -9999.0 0.0 -0.248 26.0 26.0 SHH -0.032 0.07 -9999.0 0.0 -0.287 10.0 10.0 catabolic process 0.001 0.1 -9999.0 0.0 -0.369 9.0 9.0 SMO/Vitamin D3 -0.014 0.105 -9999.0 0.0 -0.472 4.0 4.0 SHH Np/Cholesterol/Hhip -0.025 0.083 -9999.0 0.0 -0.225 20.0 20.0 LRP2 -0.073 0.176 -9999.0 0.0 -0.402 32.0 32.0 receptor-mediated endocytosis -0.042 0.129 -9999.0 0.0 -0.436 9.0 9.0 SHH Np/Cholesterol/BOC -0.004 0.062 -9999.0 0.0 -0.221 10.0 10.0 SHH Np/Cholesterol/CDO -0.006 0.064 -9999.0 0.0 -0.221 11.0 11.0 mesenchymal cell differentiation 0.025 0.082 0.224 20.0 -9999.0 0.0 20.0 mol:Vitamin D3 0.029 0.132 0.196 30.0 -0.328 7.0 37.0 IHH N/PTCH2 0.029 0.07 -9999.0 0.0 -0.332 4.0 4.0 CDON 0.022 0.062 -9999.0 0.0 -0.402 3.0 3.0 IHH N/PTCH1 0.01 0.104 -9999.0 0.0 -0.37 9.0 9.0 Megalin/LRPAP1 -0.036 0.136 -9999.0 0.0 -0.287 32.0 32.0 PTCH2 0.019 0.071 -9999.0 0.0 -0.402 4.0 4.0 SHH Np/Cholesterol -0.009 0.058 -9999.0 0.0 -0.216 10.0 10.0 PTCH1 0.001 0.101 -9999.0 0.0 -0.37 9.0 9.0 HHIP -0.032 0.141 -9999.0 0.0 -0.402 18.0 18.0