E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.008 0.051 -9999.0 0.0 -0.293 13.0 13.0 KLHL20 0.029 0.067 0.173 31.0 -0.188 12.0 43.0 CYFIP2 0.018 0.016 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.006 0.039 0.165 11.0 -0.162 9.0 20.0 ENAH 0.006 0.051 -9999.0 0.0 -0.294 13.0 13.0 AP1M1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B -0.0 0.0 -9999.0 0.0 -0.0 1.0 1.0 RAP1A 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.028 0.033 0.111 21.0 -0.121 7.0 28.0 ABI1/Sra1/Nap1 -0.01 0.022 -9999.0 0.0 -0.118 14.0 14.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.072 0.034 -9999.0 0.0 -0.071 1.0 1.0 RAPGEF1 -0.001 0.059 0.164 32.0 -0.274 10.0 42.0 CTNND1 0.03 0.014 -9999.0 0.0 -0.065 10.0 10.0 regulation of calcium-dependent cell-cell adhesion 0.021 0.054 -9999.0 0.0 -0.295 13.0 13.0 CRK 0.006 0.06 0.173 26.0 -0.285 12.0 38.0 E-cadherin/gamma catenin/alpha catenin 0.059 0.026 -9999.0 0.0 -0.055 20.0 20.0 alphaE/beta7 Integrin 0.046 0.012 -9999.0 0.0 -0.051 2.0 2.0 IQGAP1 0.009 0.041 -9999.0 0.0 -0.065 120.0 120.0 NCKAP1 0.032 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.036 0.017 -9999.0 0.0 -0.023 39.0 39.0 DLG1 0.007 0.051 -9999.0 0.0 -0.293 13.0 13.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.029 0.018 -9999.0 0.0 -0.093 11.0 11.0 MLLT4 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.036 0.017 -9999.0 0.0 -0.023 28.0 28.0 PI3K -0.036 0.022 -9999.0 0.0 -0.118 10.0 10.0 ARF6 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -0.0 1.0 1.0 E-cadherin/gamma catenin 0.043 0.022 -9999.0 0.0 -0.058 19.0 19.0 TIAM1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.066 0.033 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.016 0.036 0.148 7.0 -0.099 2.0 9.0 PIK3R1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.03 0.013 -9999.0 0.0 -0.065 8.0 8.0 RhoA/GDP 0.012 0.059 0.173 27.0 -0.164 16.0 43.0 actin cytoskeleton organization 0.024 0.054 0.141 32.0 -0.139 12.0 44.0 CDC42/GDP 0.011 0.056 0.172 23.0 -0.163 16.0 39.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.011 0.026 -9999.0 0.0 -0.107 19.0 19.0 ITGB7 0.031 0.008 -9999.0 0.0 -0.065 2.0 2.0 RAC1 0.023 0.015 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.072 0.036 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.052 0.021 -9999.0 0.0 -0.04 9.0 9.0 mol:GDP -0.002 0.06 0.171 28.0 -0.178 16.0 44.0 CDC42/GTP/IQGAP1 0.022 0.036 -9999.0 0.0 -0.041 119.0 119.0 JUP 0.029 0.017 -9999.0 0.0 -0.065 16.0 16.0 p120 catenin/RhoA/GDP 0.025 0.062 0.185 28.0 -0.168 16.0 44.0 RAC1/GTP/IQGAP1 0.016 0.032 -9999.0 0.0 -0.04 89.0 89.0 PIP5K1C/AP1M1 0.022 0.006 -9999.0 0.0 0.0 37.0 37.0 RHOA 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.015 0.039 0.108 27.0 -0.094 14.0 41.0 NME1 -0.0 0.0 -9999.0 0.0 -0.0 7.0 7.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.007 0.051 -9999.0 0.0 -0.294 13.0 13.0 regulation of cell-cell adhesion -0.029 0.016 0.043 1.0 -0.101 11.0 12.0 WASF2 -0.006 0.012 -9999.0 0.0 -0.065 14.0 14.0 Rap1/GTP -0.022 0.044 0.142 30.0 -0.141 4.0 34.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.082 0.043 -9999.0 0.0 -0.091 1.0 1.0 CCND1 0.017 0.046 0.124 27.0 -0.113 14.0 41.0 VAV2 0.014 0.112 -9999.0 0.0 -0.567 13.0 13.0 RAP1/GDP -0.011 0.051 0.16 32.0 -0.178 2.0 34.0 adherens junction assembly 0.007 0.052 -9999.0 0.0 -0.286 14.0 14.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.054 0.038 0.189 2.0 -0.093 1.0 3.0 E-cadherin/beta catenin 0.005 0.022 -9999.0 0.0 -0.139 7.0 7.0 mol:GTP -0.0 0.0 -9999.0 0.0 -0.0 7.0 7.0 SRC 0.007 0.049 -9999.0 0.0 -0.293 12.0 12.0 PIK3CA 0.028 0.018 -9999.0 0.0 -0.065 17.0 17.0 Rac1/GTP -0.007 0.054 -9999.0 0.0 -0.274 14.0 14.0 E-cadherin/beta catenin/alpha catenin 0.06 0.021 -9999.0 0.0 -0.049 9.0 9.0 ITGAE 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.021 0.055 -9999.0 0.0 -0.3 13.0 13.0