Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.049 0.018 0.055 1.0 -0.104 19.0 20.0 KIRREL 0.035 0.011 0.084 1.0 -0.038 5.0 6.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.049 0.019 0.104 19.0 -0.055 1.0 20.0 PLCG1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.023 0.015 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.068 0.046 0.179 7.0 -9999.0 0.0 7.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.016 0.019 -9999.0 0.0 -0.111 5.0 5.0 FYN -0.01 0.044 0.163 28.0 -9999.0 0.0 28.0 mol:Ca2+ 0.074 0.036 0.172 19.0 -9999.0 0.0 19.0 mol:DAG 0.075 0.037 0.175 19.0 -9999.0 0.0 19.0 NPHS2 0.035 0.01 0.076 2.0 -0.03 4.0 6.0 mol:IP3 0.075 0.037 0.175 19.0 -9999.0 0.0 19.0 regulation of endocytosis 0.055 0.029 0.134 1.0 -0.058 4.0 5.0 Nephrin/NEPH1/podocin/Cholesterol 0.062 0.029 0.157 19.0 -0.039 5.0 24.0 establishment of cell polarity 0.049 0.018 0.104 19.0 -0.055 1.0 20.0 Nephrin/NEPH1/podocin/NCK1-2 0.09 0.039 0.188 10.0 -9999.0 0.0 10.0 Nephrin/NEPH1/beta Arrestin2 0.057 0.031 0.14 1.0 -0.059 4.0 5.0 NPHS1 0.034 0.011 0.093 1.0 -9999.0 0.0 1.0 Nephrin/NEPH1/podocin 0.059 0.024 0.166 4.0 -0.053 5.0 9.0 TJP1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.029 0.015 -9999.0 0.0 -0.065 11.0 11.0 NCK2 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.077 0.038 0.178 19.0 -9999.0 0.0 19.0 CD2AP 0.023 0.029 -9999.0 0.0 -0.065 48.0 48.0 Nephrin/NEPH1/podocin/GRB2 0.078 0.035 0.179 16.0 -9999.0 0.0 16.0 GRB2 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.012 0.05 0.173 30.0 -9999.0 0.0 30.0 cytoskeleton organization -0.007 0.032 0.172 11.0 -0.146 3.0 14.0 Nephrin/NEPH1 0.041 0.016 0.087 19.0 -0.029 5.0 24.0 Nephrin/NEPH1/ZO-1 0.062 0.024 -9999.0 0.0 -0.043 5.0 5.0