Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.018 0.027 0.155 9.0 -0.085 14.0 23.0 IHH 0.037 0.021 0.113 16.0 -0.05 1.0 17.0 SHH Np/Cholesterol/GAS1 0.013 0.02 -9999.0 0.0 -0.042 37.0 37.0 LRPAP1 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.013 0.02 0.042 37.0 -9999.0 0.0 37.0 SMO/beta Arrestin2 0.066 0.057 0.156 122.0 -0.144 1.0 123.0 SMO 0.014 0.019 0.137 3.0 -9999.0 0.0 3.0 AKT1 0.003 0.082 -9999.0 0.0 -0.311 24.0 24.0 ARRB2 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.014 0.019 0.137 3.0 -9999.0 0.0 3.0 STIL 0.024 0.085 0.17 126.0 -9999.0 0.0 126.0 DHH N/PTCH2 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.017 0.014 -9999.0 0.0 -0.066 1.0 1.0 PIK3CA 0.028 0.018 -9999.0 0.0 -0.065 17.0 17.0 DHH -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.015 0.025 0.149 8.0 -0.095 6.0 14.0 determination of left/right symmetry 0.014 0.019 0.137 3.0 -9999.0 0.0 3.0 PIK3R1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.015 0.024 0.149 8.0 -0.095 6.0 14.0 IHH N/Hhip 0.025 0.012 0.071 17.0 -9999.0 0.0 17.0 DHH N/Hhip -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.014 0.019 0.137 3.0 -9999.0 0.0 3.0 pancreas development 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.039 0.023 -9999.0 0.0 -0.051 16.0 16.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.021 0.03 -9999.0 0.0 -0.052 69.0 69.0 somite specification 0.014 0.019 0.137 3.0 -9999.0 0.0 3.0 SHH Np/Cholesterol/PTCH1 0.014 0.017 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH2 0.018 0.014 -9999.0 0.0 -0.03 4.0 4.0 SHH Np/Cholesterol/Megalin 0.018 0.014 -9999.0 0.0 -0.033 5.0 5.0 SHH -0.015 0.01 0.0 168.0 -9999.0 0.0 168.0 catabolic process 0.02 0.017 -9999.0 0.0 -0.077 1.0 1.0 SMO/Vitamin D3 0.016 0.032 0.18 14.0 -9999.0 0.0 14.0 SHH Np/Cholesterol/Hhip -0.011 0.007 0.0 164.0 -9999.0 0.0 164.0 LRP2 0.032 0.005 -9999.0 0.0 -0.065 1.0 1.0 receptor-mediated endocytosis 0.012 0.028 0.153 13.0 -9999.0 0.0 13.0 SHH Np/Cholesterol/BOC -0.011 0.007 0.0 164.0 -9999.0 0.0 164.0 SHH Np/Cholesterol/CDO 0.018 0.014 -9999.0 0.0 -0.03 4.0 4.0 mesenchymal cell differentiation 0.011 0.007 -9999.0 0.0 0.0 164.0 164.0 mol:Vitamin D3 0.064 0.083 0.19 148.0 -9999.0 0.0 148.0 IHH N/PTCH2 0.05 0.012 0.105 8.0 -0.036 1.0 9.0 CDON 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.036 0.021 -9999.0 0.0 -0.064 13.0 13.0 Megalin/LRPAP1 0.047 0.007 -9999.0 0.0 -0.051 1.0 1.0 PTCH2 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.01 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 0.02 0.017 -9999.0 0.0 -0.077 1.0 1.0 HHIP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0