Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Chi-square test_P	Chi-square test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Chi-square test_P	Chi-square test_Q
PIK3CA	64 (21%)	242	0.17324	1	0.029799	1	0.70167	1	0.88079	1	0.080005	1	0.35624	1	0.044523	1	0.48456	1	0.78934	1	0.4898	1
CDKN2A	65 (21%)	241	0.14232	1	0.001934	0.625	0.0012026	0.396	0.30736	1	0.21442	1	0.35724	1	0.31208	1	0.16553	1	0.63907	1	0.56851	1
HRAS	10 (3%)	296	0.00012695	0.0427	0.0016451	0.535	0.38923	1	0.23445	1	0.0014143	0.462	0.001203	0.396	0.26158	1	0.23019	1	0.62584	1	0.4109	1
TP53	213 (70%)	93	8.2209e-13	2.84e-10	1.3956e-19	4.84e-17	0.085796	1	0.062787	1	0.0058393	1	0.00016356	0.0548	0.051065	1	0.00023177	0.0772	0.047214	1	0.0036704	1
NFE2L2	17 (6%)	289	0.91592	1	3.0219e-05	0.0102	0.34776	1	1	1	1	1	0.86227	1	0.7243	1	0.20874	1	0.3974	1	0.41902	1
NOTCH1	57 (19%)	249	0.11464	1	0.0081786	1	0.057686	1	0.026686	1	0.0033906	1	0.00054892	0.181	0.00026866	0.0892	0.22996	1	0.033696	1	0.011882	1
NSD1	33 (11%)	273	0.06671	1	2.7845e-23	9.69e-21	0.097422	1	0.45874	1	0.00021377	0.0714	1.0858e-05	0.00369	0.08065	1	0.015344	1	0.034143	1	0.048216	1
FAT1	69 (23%)	237	0.68138	1	0.1299	1	0.90528	1	1	1	0.14231	1	0.25365	1	0.084246	1	0.23486	1	0.92969	1	0.48415	1
CASP8	27 (9%)	279	7.3666e-07	0.000252	4.6684e-11	1.61e-08	0.016809	1	0.31125	1	2.2235e-08	7.65e-06	2.5457e-08	8.73e-06	0.051963	1	0.20854	1	0.19247	1	0.12631	1
JUB	18 (6%)	288	0.2749	1	0.079594	1	0.39679	1	0.46555	1	0.14145	1	0.50309	1	0.096193	1	1	1	0.077896	1	0.95262	1
MLL2	53 (17%)	253	0.1406	1	0.0405	1	0.49985	1	0.81142	1	0.11181	1	0.18655	1	0.067721	1	0.0018215	0.59	0.49941	1	0.19474	1
FBXW7	15 (5%)	291	0.47098	1	0.12479	1	0.41645	1	0.13392	1	0.65308	1	1	1	0.81047	1	0.76573	1	0.54595	1	0.046464	1
ZNF750	13 (4%)	293	1	1	0.13634	1	0.80492	1	0.52629	1	0.078972	1	0.10491	1	0.70795	1	1	1	0.42469	1	0.76385	1
EPHA2	13 (4%)	293	0.21328	1	0.0014379	0.469	0.74122	1	0.90154	1	0.070991	1	0.11412	1	0.10058	1	0.0058961	1	0.13832	1	0.22858	1
FLG	47 (15%)	259	0.91948	1	0.084405	1	0.54762	1	0.76207	1	0.049346	1	0.079064	1	0.040523	1	0.14855	1	0.39992	1	0.26035	1
B2M	7 (2%)	299	0.21866	1	0.066992	1	NA	NA	NA	NA	0.58483	1	0.44961	1	0.33001	1	0.78733	1	0.65757	1	0.85587	1
EP300	24 (8%)	282	0.41893	1	0.50292	1	0.57326	1	0.27816	1	0.0056136	1	0.017415	1	0.40952	1	0.84718	1	0.73473	1	0.2674	1
RHOA	4 (1%)	302	0.059949	1	0.092072	1	0.13771	1	0.44934	1	0.82533	1	0.21238	1	0.073405	1	0.43052	1	0.037481	1	0.039799	1
HLA-A	9 (3%)	297	0.36701	1	0.18643	1	1	1	0.45294	1	0.19019	1	0.22983	1	0.61245	1	0.057332	1	0.6946	1	0.38063	1
CTCF	11 (4%)	295	0.18152	1	0.029629	1	0.61574	1	0.85648	1	0.42543	1	0.44481	1	0.48401	1	0.53433	1	0.71508	1	0.97201	1
RB1	10 (3%)	296	0.70347	1	0.40616	1	0.3271	1	0.12253	1	0.045853	1	0.031426	1	0.16061	1	1	1	0.53224	1	0.062928	1
CSMD3	70 (23%)	236	0.004707	1	8.1705e-05	0.0275	0.013041	1	0.15033	1	1.0889e-05	0.00369	1.0394e-05	0.00354	0.00037231	0.123	0.013294	1	0.0043773	1	0.0044982	1
TGFBR2	10 (3%)	296	0.54175	1	0.027371	1	0.43789	1	1	1	0.2307	1	0.5964	1	0.91762	1	1	1	0.8971	1	0.24401	1
NECAB1	6 (2%)	300	0.36178	1	0.1568	1	0.87231	1	0.65911	1	0.074645	1	0.018007	1	0.58056	1	0.5536	1	0.51199	1	0.16744	1
MAPK1	4 (1%)	302	0.29702	1	0.88492	1	1	1	0.74281	1	0.6882	1	0.35115	1	0.68227	1	0.19702	1	0.69697	1	0.98421	1
EPB41L3	16 (5%)	290	0.2026	1	0.02956	1	0.6751	1	0.12819	1	0.068799	1	0.015392	1	0.13079	1	0.11698	1	0.32603	1	0.32319	1
RAC1	9 (3%)	297	0.23287	1	0.50947	1	1	1	0.74281	1	0.19019	1	0.037151	1	0.28026	1	0.15645	1	0.37544	1	0.13699	1
CUL3	10 (3%)	296	0.27706	1	0.12195	1	0.37653	1	0.19932	1	0.46961	1	0.78071	1	0.64881	1	0.50391	1	0.37471	1	0.68566	1
PRB1	7 (2%)	299	0.058816	1	0.14891	1	0.35663	1	0.65911	1	0.88919	1	0.48518	1	0.24162	1	0.30357	1	0.0022616	0.728	0.98666	1
TRPV4	7 (2%)	299	0.84727	1	0.90998	1	1	1	1	1	0.49618	1	0.26134	1	0.11314	1	0.45923	1	0.71389	1	0.077756	1
EPDR1	6 (2%)	300	0.54443	1	0.30219	1	0.71413	1	0.77307	1	0.33014	1	0.65546	1	1	1	0.77176	1	0.055642	1	0.69706	1
SLC26A7	8 (3%)	298	0.6434	1	0.40282	1	0.39401	1	0.28899	1	0.12847	1	0.079498	1	0.5731	1	0.64197	1	0.29658	1	0.57054	1
KCNA3	8 (3%)	298	0.86912	1	0.84231	1	0.045173	1	0.59184	1	0.54883	1	0.21544	1	0.81128	1	0.64197	1	0.56774	1	0.21037	1
HIST1H1B	7 (2%)	299	0.60539	1	0.28419	1	0.94457	1	0.64842	1	0.72071	1	0.43542	1	0.61121	1	0.01879	1	0.71389	1	0.078899	1
STEAP4	10 (3%)	296	0.14674	1	0.59462	1	0.17149	1	0.11962	1	0.099298	1	0.21536	1	0.28506	1	0.58438	1	0.71508	1	0.38133	1