Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.284 0.236 -9999.0 0.0 -0.919 15.0 15.0 IHH -0.056 0.07 -9999.0 0.0 -0.773 2.0 2.0 SHH Np/Cholesterol/GAS1 -0.045 0.141 -9999.0 0.0 -0.499 35.0 35.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.045 0.14 0.495 35.0 -9999.0 0.0 35.0 SMO/beta Arrestin2 -0.148 0.157 -9999.0 0.0 -0.605 21.0 21.0 SMO -0.163 0.166 -9999.0 0.0 -0.644 21.0 21.0 AKT1 -0.065 0.095 -9999.0 0.0 -0.731 3.0 3.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.038 0.171 -9999.0 0.0 -0.597 36.0 36.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.161 0.163 -9999.0 0.0 -0.632 21.0 21.0 STIL -0.14 0.172 -9999.0 0.0 -0.623 29.0 29.0 DHH N/PTCH2 -0.016 0.094 -9999.0 0.0 -0.535 13.0 13.0 DHH N/PTCH1 -0.141 0.144 -9999.0 0.0 -0.738 9.0 9.0 PIK3CA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.008 0.057 -9999.0 0.0 -0.817 2.0 2.0 PTHLH -0.467 0.335 -9999.0 0.0 -0.662 308.0 308.0 determination of left/right symmetry -0.161 0.163 -9999.0 0.0 -0.632 21.0 21.0 PIK3R1 0.009 0.051 -9999.0 0.0 -0.591 3.0 3.0 skeletal system development -0.462 0.331 -9999.0 0.0 -0.656 308.0 308.0 IHH N/Hhip -0.055 0.166 -9999.0 0.0 -0.681 27.0 27.0 DHH N/Hhip -0.039 0.152 -9999.0 0.0 -0.62 27.0 27.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.161 0.163 -9999.0 0.0 -0.632 21.0 21.0 pancreas development -0.037 0.193 -9999.0 0.0 -0.806 25.0 25.0 HHAT 0.011 0.041 -9999.0 0.0 -0.591 2.0 2.0 PI3K -0.003 0.036 -9999.0 0.0 -0.426 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.003 0.086 -9999.0 0.0 -0.704 6.0 6.0 somite specification -0.161 0.163 -9999.0 0.0 -0.632 21.0 21.0 SHH Np/Cholesterol/PTCH1 -0.153 0.179 -9999.0 0.0 -0.598 40.0 40.0 SHH Np/Cholesterol/PTCH2 -0.05 0.157 -9999.0 0.0 -0.541 34.0 34.0 SHH Np/Cholesterol/Megalin -0.067 0.188 -9999.0 0.0 -0.557 50.0 50.0 SHH -0.032 0.173 -9999.0 0.0 -0.616 34.0 34.0 catabolic process -0.167 0.157 -9999.0 0.0 -0.678 12.0 12.0 SMO/Vitamin D3 -0.161 0.181 -9999.0 0.0 -0.638 31.0 31.0 SHH Np/Cholesterol/Hhip -0.068 0.194 -9999.0 0.0 -0.578 48.0 48.0 LRP2 -0.036 0.191 -9999.0 0.0 -0.817 24.0 24.0 receptor-mediated endocytosis -0.178 0.177 -9999.0 0.0 -0.646 37.0 37.0 SHH Np/Cholesterol/BOC -0.067 0.158 -9999.0 0.0 -0.451 49.0 49.0 SHH Np/Cholesterol/CDO -0.047 0.142 -9999.0 0.0 -0.504 33.0 33.0 mesenchymal cell differentiation 0.067 0.192 0.573 48.0 -9999.0 0.0 48.0 mol:Vitamin D3 -0.152 0.18 -9999.0 0.0 -0.596 40.0 40.0 IHH N/PTCH2 -0.027 0.103 -9999.0 0.0 -0.582 13.0 13.0 CDON -0.001 0.092 -9999.0 0.0 -0.591 10.0 10.0 IHH N/PTCH1 -0.168 0.158 -9999.0 0.0 -0.684 12.0 12.0 Megalin/LRPAP1 -0.035 0.145 -9999.0 0.0 -0.626 24.0 24.0 PTCH2 -0.005 0.114 -9999.0 0.0 -0.694 11.0 11.0 SHH Np/Cholesterol -0.036 0.137 -9999.0 0.0 -0.498 34.0 34.0 PTCH1 -0.168 0.158 -9999.0 0.0 -0.682 12.0 12.0 HHIP -0.037 0.193 -9999.0 0.0 -0.808 25.0 25.0