Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.163 0.142 -9999.0 0.0 -0.55 15.0 15.0 IHH -0.041 0.058 -9999.0 0.0 -0.374 2.0 2.0 SHH Np/Cholesterol/GAS1 0.002 0.069 -9999.0 0.0 -0.216 37.0 37.0 LRPAP1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.002 0.069 0.214 37.0 -9999.0 0.0 37.0 SMO/beta Arrestin2 -0.088 0.123 -9999.0 0.0 -0.461 21.0 21.0 SMO -0.093 0.125 -9999.0 0.0 -0.482 22.0 22.0 AKT1 -0.044 0.116 -9999.0 0.0 -0.514 16.0 16.0 ARRB2 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.015 0.134 -9999.0 0.0 -0.465 34.0 34.0 ADRBK1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.091 0.124 -9999.0 0.0 -0.475 22.0 22.0 STIL -0.09 0.103 -9999.0 0.0 -0.401 14.0 14.0 DHH N/PTCH2 0.029 0.061 -9999.0 0.0 -0.305 13.0 13.0 DHH N/PTCH1 -0.089 0.102 -9999.0 0.0 -0.499 8.0 8.0 PIK3CA 0.02 0.013 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.022 0.032 -9999.0 0.0 -0.393 2.0 2.0 PTHLH -0.224 0.177 -9999.0 0.0 -0.597 24.0 24.0 determination of left/right symmetry -0.091 0.124 -9999.0 0.0 -0.475 22.0 22.0 PIK3R1 0.023 0.042 -9999.0 0.0 -0.468 3.0 3.0 skeletal system development -0.223 0.176 -9999.0 0.0 -0.592 24.0 24.0 IHH N/Hhip -0.033 0.084 -9999.0 0.0 -0.323 26.0 26.0 DHH N/Hhip 0.018 0.077 -9999.0 0.0 -0.281 26.0 26.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.091 0.124 -9999.0 0.0 -0.475 22.0 22.0 pancreas development -0.006 0.098 -9999.0 0.0 -0.397 24.0 24.0 HHAT 0.025 0.034 -9999.0 0.0 -0.468 2.0 2.0 PI3K 0.027 0.032 -9999.0 0.0 -0.336 2.0 2.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.022 0.049 -9999.0 0.0 -0.423 5.0 5.0 somite specification -0.091 0.124 -9999.0 0.0 -0.475 22.0 22.0 SHH Np/Cholesterol/PTCH1 -0.096 0.101 -9999.0 0.0 -0.352 30.0 30.0 SHH Np/Cholesterol/PTCH2 -0.001 0.079 -9999.0 0.0 -0.233 41.0 41.0 SHH Np/Cholesterol/Megalin -0.01 0.084 -9999.0 0.0 -0.232 49.0 49.0 SHH -0.02 0.078 -9999.0 0.0 -0.281 33.0 33.0 catabolic process -0.105 0.107 -9999.0 0.0 -0.439 14.0 14.0 SMO/Vitamin D3 -0.089 0.115 -9999.0 0.0 -0.469 13.0 13.0 SHH Np/Cholesterol/Hhip -0.012 0.089 -9999.0 0.0 -0.243 49.0 49.0 LRP2 -0.005 0.097 -9999.0 0.0 -0.394 24.0 24.0 receptor-mediated endocytosis -0.093 0.119 -9999.0 0.0 -0.508 14.0 14.0 SHH Np/Cholesterol/BOC -0.016 0.093 -9999.0 0.0 -0.241 59.0 59.0 SHH Np/Cholesterol/CDO -0.002 0.076 -9999.0 0.0 -0.227 41.0 41.0 mesenchymal cell differentiation 0.012 0.088 0.242 49.0 -9999.0 0.0 49.0 mol:Vitamin D3 -0.091 0.11 0.371 1.0 -0.388 19.0 20.0 IHH N/PTCH2 -0.022 0.07 -9999.0 0.0 -0.343 13.0 13.0 CDON 0.015 0.072 -9999.0 0.0 -0.468 9.0 9.0 IHH N/PTCH1 -0.103 0.111 -9999.0 0.0 -0.442 14.0 14.0 Megalin/LRPAP1 0.019 0.073 -9999.0 0.0 -0.272 24.0 24.0 PTCH2 0.015 0.074 -9999.0 0.0 -0.435 11.0 11.0 SHH Np/Cholesterol -0.002 0.062 -9999.0 0.0 -0.212 33.0 33.0 PTCH1 -0.105 0.108 -9999.0 0.0 -0.441 14.0 14.0 HHIP -0.006 0.098 -9999.0 0.0 -0.398 24.0 24.0