Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.02 0.033 -9999.0 0.0 -0.28 4.0 4.0 epithelial cell differentiation 0.048 0.034 -9999.0 0.0 -0.242 2.0 2.0 CYFIP2 0.025 0.032 -9999.0 0.0 -0.43 2.0 2.0 ENAH 0.019 0.069 0.233 11.0 -9999.0 0.0 11.0 EGFR 0.022 0.035 -9999.0 0.0 -0.468 2.0 2.0 EPHA2 0.021 0.054 -9999.0 0.0 -0.468 5.0 5.0 MYO6 0.018 0.037 0.211 1.0 -9999.0 0.0 1.0 CTNNB1 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.05 0.028 -9999.0 0.0 -0.259 2.0 2.0 AQP5 -0.293 0.216 -9999.0 0.0 -0.458 242.0 242.0 CTNND1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.018 0.036 0.209 1.0 -9999.0 0.0 1.0 regulation of calcium-dependent cell-cell adhesion 0.002 0.064 -9999.0 0.0 -9999.0 0.0 0.0 EGF -0.062 0.189 -9999.0 0.0 -0.466 75.0 75.0 NCKAP1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.09 0.19 -9999.0 0.0 -0.464 69.0 69.0 cortical microtubule organization 0.048 0.034 -9999.0 0.0 -0.242 2.0 2.0 GO:0000145 -0.0 0.037 0.189 3.0 -9999.0 0.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.053 0.036 -9999.0 0.0 -0.244 2.0 2.0 MLLT4 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.013 0.025 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.055 0.043 -9999.0 0.0 -0.26 4.0 4.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.008 0.028 0.212 1.0 -9999.0 0.0 1.0 PVRL2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.018 0.035 0.211 1.0 -9999.0 0.0 1.0 ARF6/GTP 0.059 0.045 -9999.0 0.0 -0.243 4.0 4.0 CDH1 0.022 0.048 -9999.0 0.0 -0.468 4.0 4.0 EGFR/EGFR/EGF/EGF -0.007 0.102 -9999.0 0.0 -0.332 2.0 2.0 RhoA/GDP 0.05 0.033 -9999.0 0.0 -0.232 2.0 2.0 actin cytoskeleton organization -0.002 0.037 0.195 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.044 0.174 -9999.0 0.0 -0.462 62.0 62.0 DIAPH1 0.019 0.123 -9999.0 0.0 -0.558 1.0 1.0 Wnt receptor signaling pathway -0.048 0.034 0.242 2.0 -9999.0 0.0 2.0 RHOA 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.013 0.025 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.002 0.037 0.197 1.0 -9999.0 0.0 1.0 EFNA1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.003 0.03 0.196 3.0 -9999.0 0.0 3.0 Ephrin A1/EPHA2 0.04 0.042 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.01 0.02 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.002 0.065 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET 0.03 0.062 -9999.0 0.0 -0.342 1.0 1.0 HGF 0.008 0.091 -9999.0 0.0 -0.444 16.0 16.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.021 0.034 -9999.0 0.0 -0.282 4.0 4.0 actin cable formation 0.055 0.094 0.234 63.0 -9999.0 0.0 63.0 KIAA1543 -0.013 0.064 0.191 3.0 -0.361 3.0 6.0 KIFC3 0.015 0.03 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.017 0.035 0.211 1.0 -9999.0 0.0 1.0 NCK1/GIT1 0.035 0.016 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.048 0.034 -9999.0 0.0 -0.242 2.0 2.0 EXOC4 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.019 0.036 0.211 1.0 -9999.0 0.0 1.0 PIP5K1C 0.018 0.037 0.211 1.0 -9999.0 0.0 1.0 LIMA1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.026 0.08 0.274 11.0 -9999.0 0.0 11.0 adherens junction assembly -0.008 0.092 0.279 6.0 -0.48 5.0 11.0 IGF-1R heterotetramer/IGF1 0.008 0.095 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.04 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.023 0.043 -9999.0 0.0 -0.412 4.0 4.0 PLEKHA7 0.004 0.069 0.211 1.0 -0.378 3.0 4.0 mol:GTP 0.053 0.042 -9999.0 0.0 -0.259 4.0 4.0 establishment of epithelial cell apical/basal polarity 0.024 0.081 0.326 10.0 -9999.0 0.0 10.0 cortical actin cytoskeleton stabilization 0.02 0.033 -9999.0 0.0 -0.28 4.0 4.0 regulation of cell-cell adhesion -0.002 0.037 0.195 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.021 0.034 -9999.0 0.0 -0.282 4.0 4.0