Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.007 0.113 -9999.0 0.0 -9999.0 0.0 0.0 IHH -0.041 0.215 -9999.0 0.0 -0.663 7.0 7.0 SHH Np/Cholesterol/GAS1 -0.115 0.189 -9999.0 0.0 -0.383 22.0 22.0 LRPAP1 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.115 0.188 0.38 22.0 -9999.0 0.0 22.0 SMO/beta Arrestin2 -0.047 0.174 -9999.0 0.0 -0.519 6.0 6.0 SMO -0.062 0.177 -9999.0 0.0 -0.523 7.0 7.0 AKT1 -0.014 0.086 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.03 0.028 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.061 0.174 -9999.0 0.0 -0.514 7.0 7.0 STIL -0.097 0.189 -9999.0 0.0 -0.379 16.0 16.0 DHH N/PTCH2 -0.015 0.147 -9999.0 0.0 -0.479 6.0 6.0 DHH N/PTCH1 -0.038 0.159 -9999.0 0.0 -0.356 13.0 13.0 PIK3CA 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.038 0.19 -9999.0 0.0 -0.639 6.0 6.0 PTHLH -0.018 0.139 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry -0.061 0.174 -9999.0 0.0 -0.514 7.0 7.0 PIK3R1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.018 0.139 -9999.0 0.0 -0.432 4.0 4.0 IHH N/Hhip -0.013 0.142 -9999.0 0.0 -0.424 7.0 7.0 DHH N/Hhip -0.016 0.148 -9999.0 0.0 -0.482 6.0 6.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.061 0.174 -9999.0 0.0 -0.514 7.0 7.0 pancreas development 0.012 0.017 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.025 0.176 -9999.0 0.0 -0.639 5.0 5.0 somite specification -0.061 0.174 -9999.0 0.0 -0.514 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.103 0.195 -9999.0 0.0 -0.378 20.0 20.0 SHH Np/Cholesterol/PTCH2 -0.086 0.174 -9999.0 0.0 -0.381 17.0 17.0 SHH Np/Cholesterol/Megalin -0.355 0.238 -9999.0 0.0 -0.47 49.0 49.0 SHH -0.133 0.205 -9999.0 0.0 -0.481 17.0 17.0 catabolic process -0.012 0.128 -9999.0 0.0 -0.376 7.0 7.0 SMO/Vitamin D3 -0.114 0.209 -9999.0 0.0 -0.411 18.0 18.0 SHH Np/Cholesterol/Hhip -0.09 0.173 -9999.0 0.0 -0.383 17.0 17.0 LRP2 -0.457 0.289 -9999.0 0.0 -0.632 48.0 48.0 receptor-mediated endocytosis -0.3 0.252 -9999.0 0.0 -0.619 20.0 20.0 SHH Np/Cholesterol/BOC -0.086 0.175 -9999.0 0.0 -0.382 17.0 17.0 SHH Np/Cholesterol/CDO -0.085 0.176 -9999.0 0.0 -0.382 17.0 17.0 mesenchymal cell differentiation 0.089 0.172 0.38 17.0 -9999.0 0.0 17.0 mol:Vitamin D3 -0.095 0.202 -9999.0 0.0 -0.378 20.0 20.0 IHH N/PTCH2 -0.011 0.14 -9999.0 0.0 -0.416 7.0 7.0 CDON 0.024 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.003 0.132 -9999.0 0.0 -0.381 7.0 7.0 Megalin/LRPAP1 -0.332 0.226 -9999.0 0.0 -0.467 48.0 48.0 PTCH2 0.021 0.008 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.096 0.167 -9999.0 0.0 -0.379 17.0 17.0 PTCH1 -0.012 0.128 -9999.0 0.0 -0.377 7.0 7.0 HHIP 0.012 0.018 -9999.0 0.0 -9999.0 0.0 0.0