Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.249 0.257 -9999.0 0.0 -0.744 32.0 32.0 IHH -0.099 0.233 -9999.0 0.0 -0.822 46.0 46.0 SHH Np/Cholesterol/GAS1 -0.038 0.127 -9999.0 0.0 -0.454 42.0 42.0 LRPAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.037 0.126 0.45 42.0 -9999.0 0.0 42.0 SMO/beta Arrestin2 -0.148 0.153 -9999.0 0.0 -0.602 33.0 33.0 SMO -0.134 0.192 -9999.0 0.0 -0.637 33.0 33.0 AKT1 -0.042 0.093 -9999.0 0.0 -0.465 1.0 1.0 ARRB2 0.014 0.039 -9999.0 0.0 -0.862 1.0 1.0 BOC 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.132 0.189 -9999.0 0.0 -0.626 33.0 33.0 STIL -0.096 0.167 -9999.0 0.0 -0.673 10.0 10.0 DHH N/PTCH2 -0.045 0.163 -9999.0 0.0 -0.633 36.0 36.0 DHH N/PTCH1 -0.161 0.163 -9999.0 0.0 -0.619 36.0 36.0 PIK3CA 0.014 0.034 -9999.0 0.0 -0.747 1.0 1.0 DHH -0.001 0.111 -9999.0 0.0 -0.747 11.0 11.0 PTHLH -0.443 0.407 -9999.0 0.0 -0.741 315.0 315.0 determination of left/right symmetry -0.132 0.189 -9999.0 0.0 -0.626 33.0 33.0 PIK3R1 0.014 0.034 -9999.0 0.0 -0.747 1.0 1.0 skeletal system development -0.438 0.402 -9999.0 0.0 -0.733 315.0 315.0 IHH N/Hhip -0.203 0.311 -9999.0 0.0 -0.655 156.0 156.0 DHH N/Hhip -0.154 0.257 -9999.0 0.0 -0.576 135.0 135.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.132 0.189 -9999.0 0.0 -0.626 33.0 33.0 pancreas development -0.177 0.333 -9999.0 0.0 -0.755 126.0 126.0 HHAT 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.002 0.035 -9999.0 0.0 -0.561 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.033 0.187 -9999.0 0.0 -0.751 32.0 32.0 somite specification -0.132 0.189 -9999.0 0.0 -0.626 33.0 33.0 SHH Np/Cholesterol/PTCH1 -0.135 0.145 -9999.0 0.0 -0.554 36.0 36.0 SHH Np/Cholesterol/PTCH2 -0.036 0.13 -9999.0 0.0 -0.505 36.0 36.0 SHH Np/Cholesterol/Megalin -0.048 0.151 -9999.0 0.0 -0.487 50.0 50.0 SHH 0.017 0.088 -9999.0 0.0 -0.571 11.0 11.0 catabolic process -0.156 0.194 -9999.0 0.0 -0.653 32.0 32.0 SMO/Vitamin D3 -0.113 0.179 -9999.0 0.0 -0.58 36.0 36.0 SHH Np/Cholesterol/Hhip -0.121 0.208 -9999.0 0.0 -0.463 132.0 132.0 LRP2 -0.051 0.216 -9999.0 0.0 -0.75 44.0 44.0 receptor-mediated endocytosis -0.154 0.179 -9999.0 0.0 -0.769 19.0 19.0 SHH Np/Cholesterol/BOC -0.01 0.065 -9999.0 0.0 -0.447 11.0 11.0 SHH Np/Cholesterol/CDO -0.071 0.181 -9999.0 0.0 -0.525 68.0 68.0 mesenchymal cell differentiation 0.12 0.206 0.459 132.0 -9999.0 0.0 132.0 mol:Vitamin D3 -0.11 0.173 -9999.0 0.0 -0.56 36.0 36.0 IHH N/PTCH2 -0.085 0.218 -9999.0 0.0 -0.619 69.0 69.0 CDON -0.085 0.28 -9999.0 0.0 -0.862 58.0 58.0 IHH N/PTCH1 -0.158 0.196 -9999.0 0.0 -0.663 32.0 32.0 Megalin/LRPAP1 -0.049 0.159 -9999.0 0.0 -0.563 44.0 44.0 PTCH2 -0.028 0.19 -9999.0 0.0 -0.862 25.0 25.0 SHH Np/Cholesterol -0.01 0.067 -9999.0 0.0 -0.458 11.0 11.0 PTCH1 -0.157 0.195 -9999.0 0.0 -0.656 32.0 32.0 HHIP -0.178 0.334 -9999.0 0.0 -0.756 126.0 126.0