Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	365.0	2924.0	8.0	-0.84	0.216	1000.0	-1000.0	-0.032	-1000.0
HIF-1-alpha transcription factor network	202.0	15410.0	76.0	-1.324	0.026	1000.0	-1000.0	-0.164	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	179.0	6089.0	34.0	-0.608	0.016	1000.0	-1000.0	-0.098	-1000.0
TCR signaling in naïve CD8+ T cells	141.0	13205.0	93.0	-0.661	0.33	1000.0	-1000.0	-0.115	-1000.0
TCGA08_p53	139.0	975.0	7.0	-0.651	0.312	1000.0	-1000.0	-0.024	-1000.0
Syndecan-4-mediated signaling events	117.0	7840.0	67.0	-0.647	0.11	1000.0	-1000.0	-0.126	-1000.0
Aurora B signaling	115.0	7712.0	67.0	-0.412	0.016	1000.0	-1000.0	-0.1	-1000.0
FOXA2 and FOXA3 transcription factor networks	110.0	5096.0	46.0	-1.231	0.025	1000.0	-1000.0	-0.1	-1000.0
Glypican 1 network	108.0	5193.0	48.0	-0.563	0.045	1000.0	-1000.0	-0.068	-1000.0
FOXM1 transcription factor network	105.0	5388.0	51.0	-0.822	0.04	1000.0	-1000.0	-0.198	-1000.0
IL12-mediated signaling events	102.0	8881.0	87.0	-0.7	0.165	1000.0	-1000.0	-0.163	-1000.0
PDGFR-alpha signaling pathway	100.0	4419.0	44.0	-0.278	0.034	1000.0	-1000.0	-0.087	-1000.0
amb2 Integrin signaling	82.0	6784.0	82.0	-0.559	0.016	1000.0	-1000.0	-0.121	-1000.0
JNK signaling in the CD4+ TCR pathway	73.0	1254.0	17.0	-0.41	0.016	1000.0	-1000.0	-0.101	-1000.0
IL4-mediated signaling events	70.0	6370.0	91.0	-0.837	0.541	1000.0	-1000.0	-0.193	-1000.0
EGFR-dependent Endothelin signaling events	70.0	1489.0	21.0	-0.67	0.016	1000.0	-1000.0	-0.107	-1000.0
Aurora C signaling	69.0	483.0	7.0	-0.4	0.012	1000.0	-1000.0	-0.061	-1000.0
Syndecan-1-mediated signaling events	66.0	2274.0	34.0	-0.415	0.016	1000.0	-1000.0	-0.098	-1000.0
Glypican 2 network	66.0	266.0	4.0	-0.123	-1000.0	1000.0	-1000.0	-0.058	-1000.0
HIF-2-alpha transcription factor network	65.0	2804.0	43.0	-0.757	0.33	1000.0	-1000.0	-0.114	-1000.0
Caspase cascade in apoptosis	63.0	4694.0	74.0	-0.32	0.157	1000.0	-1000.0	-0.078	-1000.0
VEGFR1 specific signals	63.0	3578.0	56.0	-0.47	0.045	1000.0	-1000.0	-0.123	-1000.0
IL23-mediated signaling events	58.0	3539.0	60.0	-0.403	0.021	1000.0	-1000.0	-0.186	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	57.0	1905.0	33.0	-0.829	0.016	1000.0	-1000.0	-0.09	-1000.0
BMP receptor signaling	55.0	4526.0	81.0	-0.698	0.016	1000.0	-1000.0	-0.133	-1000.0
Signaling events mediated by the Hedgehog family	49.0	2578.0	52.0	-0.443	0.12	1000.0	-1000.0	-0.116	-1000.0
Fc-epsilon receptor I signaling in mast cells	43.0	4205.0	97.0	-0.327	0.04	1000.0	-1000.0	-0.141	-1000.0
IL27-mediated signaling events	42.0	2142.0	51.0	-0.608	0.076	1000.0	-1000.0	-0.128	-1000.0
Effects of Botulinum toxin	40.0	1056.0	26.0	-0.374	0.016	1000.0	-1000.0	-0.088	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	40.0	2720.0	68.0	-0.55	0.063	1000.0	-1000.0	-0.17	-1000.0
S1P1 pathway	39.0	1427.0	36.0	-0.374	0.018	1000.0	-1000.0	-0.103	-1000.0
Ephrin A  reverse signaling	38.0	267.0	7.0	-0.056	-0.0	1000.0	-1000.0	-0.05	-1000.0
Arf6 signaling events	37.0	2323.0	62.0	-0.671	0.016	1000.0	-1000.0	-0.084	-1000.0
Calcium signaling in the CD4+ TCR pathway	37.0	1151.0	31.0	-0.458	0.016	1000.0	-1000.0	-0.155	-1000.0
p75(NTR)-mediated signaling	34.0	4314.0	125.0	-0.42	0.016	1000.0	-1000.0	-0.153	-1000.0
IL2 signaling events mediated by STAT5	34.0	750.0	22.0	-0.446	0.038	1000.0	-1000.0	-0.06	-1000.0
IL2 signaling events mediated by PI3K	33.0	1934.0	58.0	-0.444	0.031	1000.0	-1000.0	-0.115	-1000.0
LPA4-mediated signaling events	32.0	394.0	12.0	-0.165	0.026	1000.0	-1000.0	-0.038	-1000.0
PLK1 signaling events	30.0	2582.0	85.0	-0.387	0.016	1000.0	-1000.0	-0.08	-1000.0
BCR signaling pathway	30.0	3034.0	99.0	-0.333	0.034	1000.0	-1000.0	-0.134	-1000.0
Coregulation of Androgen receptor activity	29.0	2219.0	76.0	-0.92	0.033	1000.0	-1000.0	-0.082	-1000.0
IL6-mediated signaling events	28.0	2118.0	75.0	-0.285	0.076	1000.0	-1000.0	-0.115	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	27.0	1465.0	54.0	-0.654	0.031	1000.0	-1000.0	-0.132	-1000.0
EPO signaling pathway	27.0	1485.0	55.0	-0.287	0.018	1000.0	-1000.0	-0.138	-1000.0
Regulation of Telomerase	27.0	2829.0	102.0	-0.671	0.051	1000.0	-1000.0	-0.156	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	27.0	2149.0	78.0	-0.313	0.045	1000.0	-1000.0	-0.104	-1000.0
Glucocorticoid receptor regulatory network	26.0	3048.0	114.0	-0.409	0.158	1000.0	-1000.0	-0.093	-1000.0
Integrins in angiogenesis	26.0	2206.0	84.0	-0.374	0.039	1000.0	-1000.0	-0.132	-1000.0
Aurora A signaling	23.0	1434.0	60.0	-0.246	0.053	1000.0	-1000.0	-0.082	-1000.0
Angiopoietin receptor Tie2-mediated signaling	23.0	2052.0	88.0	-0.321	0.074	1000.0	-1000.0	-0.142	-1000.0
Visual signal transduction: Rods	23.0	1199.0	52.0	-0.285	0.016	1000.0	-1000.0	-0.113	-1000.0
Signaling events mediated by PTP1B	22.0	1713.0	76.0	-0.674	0.049	1000.0	-1000.0	-0.119	-1000.0
Reelin signaling pathway	22.0	1246.0	56.0	-0.237	0.016	1000.0	-1000.0	-0.12	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	21.0	974.0	45.0	-0.569	0.061	1000.0	-1000.0	-0.125	-1000.0
Syndecan-2-mediated signaling events	20.0	1389.0	69.0	-0.559	0.055	1000.0	-1000.0	-0.087	-1000.0
Endothelins	19.0	1828.0	96.0	-0.351	0.088	1000.0	-1000.0	-0.111	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	19.0	2314.0	120.0	-0.166	0.143	1000.0	-1000.0	-0.13	-1000.0
Wnt signaling	17.0	122.0	7.0	-0.071	0.016	1000.0	-1000.0	-0.079	-1000.0
Regulation of nuclear SMAD2/3 signaling	16.0	2305.0	136.0	-0.451	0.095	1000.0	-1000.0	-0.111	-1000.0
Thromboxane A2 receptor signaling	16.0	1783.0	105.0	-0.67	0.066	1000.0	-1000.0	-0.107	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	16.0	605.0	37.0	-0.294	0.025	1000.0	-1000.0	-0.107	-1000.0
S1P3 pathway	16.0	672.0	42.0	-0.37	0.062	1000.0	-1000.0	-0.081	-1000.0
Presenilin action in Notch and Wnt signaling	15.0	973.0	61.0	-0.184	0.091	1000.0	-1000.0	-0.1	-1000.0
LPA receptor mediated events	15.0	1599.0	102.0	-0.406	0.061	1000.0	-1000.0	-0.135	-1000.0
PLK2 and PLK4 events	14.0	42.0	3.0	-0.016	0.01	1000.0	-1000.0	-0.031	-1000.0
Ceramide signaling pathway	14.0	1107.0	76.0	-0.67	0.232	1000.0	-1000.0	-0.095	-1000.0
Sphingosine 1-phosphate (S1P) pathway	13.0	384.0	28.0	-0.128	0.025	1000.0	-1000.0	-0.081	-1000.0
FoxO family signaling	13.0	867.0	64.0	-0.568	0.121	1000.0	-1000.0	-0.108	-1000.0
FAS signaling pathway (CD95)	13.0	625.0	47.0	-0.426	0.029	1000.0	-1000.0	-0.071	-1000.0
Class I PI3K signaling events	13.0	977.0	73.0	-0.452	0.036	1000.0	-1000.0	-0.103	-1000.0
E-cadherin signaling events	13.0	68.0	5.0	-0.023	0.016	1000.0	-1000.0	-0.061	-1000.0
ErbB4 signaling events	12.0	833.0	69.0	-0.177	0.105	1000.0	-1000.0	-0.115	-1000.0
IFN-gamma pathway	12.0	840.0	68.0	-0.378	0.017	1000.0	-1000.0	-0.138	-1000.0
Canonical Wnt signaling pathway	12.0	662.0	51.0	-0.184	0.094	1000.0	-1000.0	-0.097	-1000.0
Nongenotropic Androgen signaling	12.0	633.0	52.0	-0.172	0.071	1000.0	-1000.0	-0.091	-1000.0
Regulation of Androgen receptor activity	12.0	860.0	70.0	-0.962	0.04	1000.0	-1000.0	-0.099	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	11.0	1405.0	125.0	-0.387	0.043	1000.0	-1000.0	-0.146	-1000.0
S1P5 pathway	10.0	177.0	17.0	-0.128	0.043	1000.0	-1000.0	-0.081	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	10.0	771.0	74.0	-0.67	0.099	1000.0	-1000.0	-0.13	-1000.0
Visual signal transduction: Cones	9.0	342.0	38.0	-0.041	0.016	1000.0	-1000.0	-0.101	-1000.0
Noncanonical Wnt signaling pathway	9.0	250.0	26.0	-0.113	0.016	1000.0	-1000.0	-0.136	-1000.0
a4b1 and a4b7 Integrin signaling	9.0	45.0	5.0	-0.02	0.016	1000.0	-1000.0	-0.054	-1000.0
S1P4 pathway	9.0	249.0	25.0	-0.128	0.035	1000.0	-1000.0	-0.081	-1000.0
TCGA08_rtk_signaling	8.0	229.0	26.0	-0.28	0.041	1000.0	-1000.0	-0.032	-1000.0
Signaling events regulated by Ret tyrosine kinase	7.0	649.0	82.0	-0.064	0.027	1000.0	-1000.0	-0.121	-1000.0
Canonical NF-kappaB pathway	6.0	260.0	39.0	-0.19	0.075	1000.0	-1000.0	-0.116	-1000.0
Signaling events mediated by PRL	6.0	213.0	34.0	-0.058	0.046	1000.0	-1000.0	-0.084	-1000.0
Class IB PI3K non-lipid kinase events	6.0	18.0	3.0	-0.006	0.006	1000.0	-1000.0	-0.015	-1000.0
p38 MAPK signaling pathway	6.0	264.0	44.0	-0.101	0.049	1000.0	-1000.0	-0.091	-1000.0
ErbB2/ErbB3 signaling events	5.0	379.0	65.0	-0.135	0.059	1000.0	-1000.0	-0.106	-1000.0
Insulin-mediated glucose transport	5.0	177.0	32.0	-0.086	0.066	1000.0	-1000.0	-0.088	-1000.0
Signaling events mediated by HDAC Class III	5.0	224.0	40.0	-0.06	0.031	1000.0	-1000.0	-0.082	-1000.0
IL1-mediated signaling events	5.0	370.0	62.0	-0.093	0.061	1000.0	-1000.0	-0.149	-1000.0
Ephrin B reverse signaling	5.0	279.0	48.0	-0.027	0.032	1000.0	-1000.0	-0.113	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	81.0	15.0	-0.0	0.037	1000.0	-1000.0	-0.056	-1000.0
Syndecan-3-mediated signaling events	5.0	177.0	35.0	-0.04	0.016	1000.0	-1000.0	-0.106	-1000.0
E-cadherin signaling in the nascent adherens junction	5.0	389.0	76.0	-0.026	0.067	1000.0	-1000.0	-0.114	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	4.0	365.0	85.0	-0.035	0.079	1000.0	-1000.0	-0.108	-1000.0
Arf6 downstream pathway	4.0	214.0	43.0	-0.033	0.033	1000.0	-1000.0	-0.065	-1000.0
Paxillin-dependent events mediated by a4b1	4.0	155.0	36.0	-0.027	0.031	1000.0	-1000.0	-0.096	-1000.0
EPHB forward signaling	4.0	345.0	85.0	-0.073	0.07	1000.0	-1000.0	-0.135	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	80.0	17.0	-0.037	0.055	1000.0	-1000.0	-0.076	-1000.0
BARD1 signaling events	3.0	223.0	57.0	-0.17	0.043	1000.0	-1000.0	-0.106	-1000.0
Cellular roles of Anthrax toxin	3.0	119.0	39.0	-0.022	0.027	1000.0	-1000.0	-0.043	-1000.0
Plasma membrane estrogen receptor signaling	3.0	324.0	86.0	-0.167	0.072	1000.0	-1000.0	-0.116	-1000.0
E-cadherin signaling in keratinocytes	3.0	134.0	43.0	-0.293	0.053	1000.0	-1000.0	-0.116	-1000.0
Osteopontin-mediated events	2.0	107.0	38.0	-0.03	0.099	1000.0	-1000.0	-0.138	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	131.0	65.0	-0.063	0.093	1000.0	-1000.0	-0.089	-1000.0
ceramide signaling pathway	2.0	138.0	49.0	-0.12	0.054	1000.0	-1000.0	-0.063	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	128.0	52.0	-0.031	0.092	1000.0	-1000.0	-0.093	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	174.0	83.0	-0.086	0.081	1000.0	-1000.0	-0.108	-1000.0
Signaling events mediated by HDAC Class I	2.0	210.0	104.0	-0.03	0.064	1000.0	-1000.0	-0.109	-1000.0
Regulation of p38-alpha and p38-beta	2.0	156.0	54.0	-0.04	0.073	1000.0	-1000.0	-0.078	-1000.0
Arf6 trafficking events	2.0	175.0	71.0	-0.127	0.058	1000.0	-1000.0	-0.112	-1000.0
IGF1 pathway	2.0	119.0	57.0	-0.066	0.071	1000.0	-1000.0	-0.141	-1000.0
Insulin Pathway	2.0	192.0	74.0	-0.035	0.055	1000.0	-1000.0	-0.144	-1000.0
PDGFR-beta signaling pathway	2.0	232.0	97.0	-0.055	0.087	1000.0	-1000.0	-0.14	-1000.0
Signaling events mediated by HDAC Class II	1.0	121.0	75.0	-0.027	0.051	1000.0	-1000.0	-0.094	-1000.0
Circadian rhythm pathway	1.0	29.0	22.0	-0.019	0.065	1000.0	-1000.0	-0.091	-1000.0
mTOR signaling pathway	1.0	62.0	53.0	-0.007	0.044	1000.0	-1000.0	-0.085	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	89.0	68.0	-0.086	0.06	1000.0	-1000.0	-0.109	-1000.0
Nectin adhesion pathway	1.0	63.0	63.0	-0.016	0.08	1000.0	-1000.0	-0.105	-1000.0
Retinoic acid receptors-mediated signaling	1.0	114.0	58.0	-0.025	0.063	1000.0	-1000.0	-0.11	-1000.0
Atypical NF-kappaB pathway	1.0	52.0	31.0	-0.022	0.036	1000.0	-1000.0	-0.105	-1000.0
Signaling mediated by p38-alpha and p38-beta	1.0	52.0	44.0	-0.042	0.051	1000.0	-1000.0	-0.089	-1000.0
Alternative NF-kappaB pathway	1.0	14.0	13.0	-0.005	0.016	1000.0	-1000.0	-0.09	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	2.0	23.0	-0.001	0.062	1000.0	-1000.0	-0.107	-1000.0
TRAIL signaling pathway	0.0	25.0	48.0	-0.002	0.071	1000.0	-1000.0	-0.102	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.039	1000.0	-1000.0	-0.082	-1000.0
Rapid glucocorticoid signaling	0.0	11.0	20.0	-0.005	0.016	1000.0	-1000.0	-0.059	-1000.0
Arf1 pathway	0.0	29.0	54.0	-0.009	0.044	1000.0	-1000.0	-0.064	-1000.0
Total	4080	212932	7203	-40.0695557352	-991.854758057	131000	-131000	-13.514757022	-131000