Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.394 0.233 0.526 369.0 -9999.0 0.0 369.0 KIRREL -0.058 0.081 -9999.0 0.0 -0.617 7.0 7.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.395 0.233 -9999.0 0.0 -0.527 369.0 369.0 PLCG1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.028 0.033 -9999.0 0.0 -0.705 1.0 1.0 WASL 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.416 0.282 -9999.0 0.0 -0.54 390.0 390.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.341 0.236 -9999.0 0.0 -0.569 216.0 216.0 FYN -0.399 0.256 0.265 1.0 -0.507 394.0 395.0 mol:Ca2+ -0.407 0.278 -9999.0 0.0 -0.532 388.0 388.0 mol:DAG -0.41 0.281 -9999.0 0.0 -0.535 388.0 388.0 NPHS2 -0.341 0.328 -9999.0 0.0 -0.691 231.0 231.0 mol:IP3 -0.41 0.281 -9999.0 0.0 -0.535 388.0 388.0 regulation of endocytosis -0.372 0.251 -9999.0 0.0 -0.502 347.0 347.0 Nephrin/NEPH1/podocin/Cholesterol -0.422 0.278 -9999.0 0.0 -0.541 394.0 394.0 establishment of cell polarity -0.394 0.233 -9999.0 0.0 -0.526 369.0 369.0 Nephrin/NEPH1/podocin/NCK1-2 -0.38 0.27 -9999.0 0.0 -0.651 204.0 204.0 Nephrin/NEPH1/beta Arrestin2 -0.378 0.256 -9999.0 0.0 -0.51 347.0 347.0 NPHS1 -0.513 0.286 -9999.0 0.0 -0.669 382.0 382.0 Nephrin/NEPH1/podocin -0.398 0.265 -9999.0 0.0 -0.511 394.0 394.0 TJP1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.027 0.031 -9999.0 0.0 -0.637 1.0 1.0 NCK2 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.412 0.283 -9999.0 0.0 -0.538 388.0 388.0 CD2AP 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 -0.414 0.283 -9999.0 0.0 -0.54 388.0 388.0 GRB2 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.391 0.256 0.276 1.0 -0.502 388.0 389.0 cytoskeleton organization -0.431 0.286 -9999.0 0.0 -0.583 349.0 349.0 Nephrin/NEPH1 -0.287 0.174 -9999.0 0.0 -0.385 369.0 369.0 Nephrin/NEPH1/ZO-1 -0.315 0.2 -9999.0 0.0 -0.429 367.0 367.0