Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.181 0.193 -9999.0 0.0 -0.583 32.0 32.0 IHH -0.081 0.195 -9999.0 0.0 -0.692 43.0 43.0 SHH Np/Cholesterol/GAS1 0.003 0.1 -9999.0 0.0 -0.374 29.0 29.0 LRPAP1 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.003 0.099 0.371 29.0 -9999.0 0.0 29.0 SMO/beta Arrestin2 -0.087 0.15 -9999.0 0.0 -0.516 26.0 26.0 SMO -0.098 0.149 -9999.0 0.0 -0.534 26.0 26.0 AKT1 -0.036 0.112 -9999.0 0.0 -0.516 13.0 13.0 ARRB2 0.028 0.033 -9999.0 0.0 -0.705 1.0 1.0 BOC 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.097 0.147 -9999.0 0.0 -0.526 26.0 26.0 STIL -0.071 0.134 -9999.0 0.0 -0.43 27.0 27.0 DHH N/PTCH2 0.007 0.125 -9999.0 0.0 -0.442 35.0 35.0 DHH N/PTCH1 -0.107 0.152 -9999.0 0.0 -0.489 35.0 35.0 PIK3CA 0.027 0.031 -9999.0 0.0 -0.637 1.0 1.0 DHH 0.014 0.098 -9999.0 0.0 -0.637 11.0 11.0 PTHLH -0.283 0.271 -9999.0 0.0 -0.794 39.0 39.0 determination of left/right symmetry -0.097 0.147 -9999.0 0.0 -0.526 26.0 26.0 PIK3R1 0.026 0.031 -9999.0 0.0 -0.637 1.0 1.0 skeletal system development -0.281 0.268 -9999.0 0.0 -0.785 39.0 39.0 IHH N/Hhip -0.162 0.254 -9999.0 0.0 -0.54 146.0 146.0 DHH N/Hhip -0.092 0.227 -9999.0 0.0 -0.477 126.0 126.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.097 0.147 -9999.0 0.0 -0.526 26.0 26.0 pancreas development -0.132 0.282 -9999.0 0.0 -0.632 119.0 119.0 HHAT 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.037 0.036 -9999.0 0.0 -0.474 2.0 2.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.009 0.151 -9999.0 0.0 -0.586 31.0 31.0 somite specification -0.097 0.147 -9999.0 0.0 -0.526 26.0 26.0 SHH Np/Cholesterol/PTCH1 -0.084 0.129 -9999.0 0.0 -0.44 28.0 28.0 SHH Np/Cholesterol/PTCH2 0.006 0.093 -9999.0 0.0 -0.343 31.0 31.0 SHH Np/Cholesterol/Megalin -0.004 0.118 -9999.0 0.0 -0.409 34.0 34.0 SHH 0.011 0.07 -9999.0 0.0 -0.471 10.0 10.0 catabolic process -0.123 0.157 -9999.0 0.0 -0.481 42.0 42.0 SMO/Vitamin D3 -0.086 0.14 -9999.0 0.0 -0.486 27.0 27.0 SHH Np/Cholesterol/Hhip -0.068 0.176 -9999.0 0.0 -0.384 109.0 109.0 LRP2 -0.022 0.173 -9999.0 0.0 -0.591 41.0 41.0 receptor-mediated endocytosis -0.099 0.163 -9999.0 0.0 -0.54 34.0 34.0 SHH Np/Cholesterol/BOC 0.021 0.057 -9999.0 0.0 -0.366 10.0 10.0 SHH Np/Cholesterol/CDO -0.016 0.121 -9999.0 0.0 -0.339 59.0 59.0 mesenchymal cell differentiation 0.068 0.174 0.381 109.0 -9999.0 0.0 109.0 mol:Vitamin D3 -0.078 0.138 -9999.0 0.0 -0.444 28.0 28.0 IHH N/PTCH2 -0.059 0.165 -9999.0 0.0 -0.466 66.0 66.0 CDON -0.041 0.196 -9999.0 0.0 -0.586 57.0 57.0 IHH N/PTCH1 -0.124 0.159 -9999.0 0.0 -0.481 44.0 44.0 Megalin/LRPAP1 0.004 0.132 -9999.0 0.0 -0.471 33.0 33.0 PTCH2 -0.002 0.134 -9999.0 0.0 -0.586 25.0 25.0 SHH Np/Cholesterol 0.011 0.055 -9999.0 0.0 -0.37 10.0 10.0 PTCH1 -0.123 0.157 -9999.0 0.0 -0.482 42.0 42.0 HHIP -0.132 0.283 -9999.0 0.0 -0.633 119.0 119.0