Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.013 0.057 -9999.0 0.0 -0.293 13.0 13.0 epithelial cell differentiation 0.028 0.071 -9999.0 0.0 -0.343 13.0 13.0 CYFIP2 0.014 0.079 -9999.0 0.0 -0.637 7.0 7.0 ENAH 0.062 0.103 0.39 17.0 -9999.0 0.0 17.0 EGFR 0.019 0.068 -9999.0 0.0 -0.594 6.0 6.0 EPHA2 0.027 0.03 -9999.0 0.0 -0.637 1.0 1.0 MYO6 0.057 0.111 0.382 13.0 -0.487 2.0 15.0 CTNNB1 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.038 0.059 -9999.0 0.0 -0.403 7.0 7.0 AQP5 -0.109 0.24 -9999.0 0.0 -0.506 111.0 111.0 CTNND1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.061 0.107 0.395 13.0 -9999.0 0.0 13.0 regulation of calcium-dependent cell-cell adhesion 0.05 0.118 0.404 11.0 -0.335 13.0 24.0 EGF -0.569 0.199 -9999.0 0.0 -0.633 450.0 450.0 NCKAP1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.007 0.157 -9999.0 0.0 -0.542 28.0 28.0 cortical microtubule organization 0.028 0.071 -9999.0 0.0 -0.343 13.0 13.0 GO:0000145 0.051 0.106 0.387 13.0 -9999.0 0.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.031 0.073 -9999.0 0.0 -0.346 13.0 13.0 MLLT4 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.008 0.046 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.065 0.042 -9999.0 0.0 -0.356 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.041 0.084 0.375 2.0 -9999.0 0.0 2.0 PVRL2 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.047 0.093 0.36 5.0 -0.33 11.0 16.0 ARF6/GTP 0.069 0.045 -9999.0 0.0 -0.342 2.0 2.0 CDH1 0.007 0.119 -9999.0 0.0 -0.619 17.0 17.0 EGFR/EGFR/EGF/EGF -0.244 0.144 -9999.0 0.0 -0.59 18.0 18.0 RhoA/GDP 0.029 0.068 -9999.0 0.0 -0.326 11.0 11.0 actin cytoskeleton organization 0.05 0.103 0.346 12.0 -0.457 2.0 14.0 IGF-1R heterotetramer 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.023 0.062 -9999.0 0.0 -0.586 5.0 5.0 DIAPH1 0.032 0.111 -9999.0 0.0 -0.669 7.0 7.0 Wnt receptor signaling pathway -0.028 0.071 0.343 13.0 -9999.0 0.0 13.0 RHOA 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.009 0.048 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.023 0.013 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.05 0.104 0.348 12.0 -0.469 2.0 14.0 EFNA1 0.027 0.028 -9999.0 0.0 -0.586 1.0 1.0 LPP 0.046 0.094 0.39 6.0 -9999.0 0.0 6.0 Ephrin A1/EPHA2 0.023 0.065 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.001 0.05 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.051 0.119 0.407 11.0 -0.341 13.0 24.0 HGF/MET 0.012 0.093 -9999.0 0.0 -0.593 3.0 3.0 HGF 0.002 0.123 -9999.0 0.0 -0.596 20.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.013 0.058 -9999.0 0.0 -0.295 13.0 13.0 actin cable formation 0.105 0.131 0.332 72.0 -9999.0 0.0 72.0 KIAA1543 0.048 0.106 0.355 10.0 -0.538 2.0 12.0 KIFC3 0.049 0.093 -9999.0 0.0 -0.33 12.0 12.0 NCK1 0.027 0.031 -9999.0 0.0 -0.637 1.0 1.0 EXOC3 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.052 0.101 0.43 7.0 -9999.0 0.0 7.0 NCK1/GIT1 0.041 0.026 -9999.0 0.0 -0.474 1.0 1.0 mol:GDP 0.028 0.071 -9999.0 0.0 -0.343 13.0 13.0 EXOC4 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.049 0.091 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.061 0.108 0.397 13.0 -9999.0 0.0 13.0 LIMA1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.075 0.112 0.411 19.0 -9999.0 0.0 19.0 adherens junction assembly 0.071 0.137 0.496 17.0 -0.718 2.0 19.0 IGF-1R heterotetramer/IGF1 0.022 0.07 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.041 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.024 0.04 -9999.0 0.0 -0.586 2.0 2.0 PLEKHA7 0.057 0.108 0.362 10.0 -0.566 2.0 12.0 mol:GTP 0.063 0.041 -9999.0 0.0 -0.354 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.081 0.124 0.378 44.0 -9999.0 0.0 44.0 cortical actin cytoskeleton stabilization 0.013 0.057 -9999.0 0.0 -0.293 13.0 13.0 regulation of cell-cell adhesion 0.05 0.103 0.346 12.0 -0.457 2.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.013 0.058 -9999.0 0.0 -0.295 13.0 13.0