Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	230.0	7830.0	34.0	-0.513	0.03	1000.0	-1000.0	-0.049	-1000.0
HIF-1-alpha transcription factor network	158.0	12053.0	76.0	-1.089	0.046	1000.0	-1000.0	-0.165	-1000.0
TCGA08_p53	150.0	1053.0	7.0	-0.419	0.221	1000.0	-1000.0	-0.01	-1000.0
TCR signaling in naïve CD8+ T cells	132.0	12279.0	93.0	-0.438	0.204	1000.0	-1000.0	-0.084	-1000.0
FOXA2 and FOXA3 transcription factor networks	120.0	5530.0	46.0	-1.103	0.036	1000.0	-1000.0	-0.117	-1000.0
TCGA08_retinoblastoma	111.0	892.0	8.0	-0.574	0.16	1000.0	-1000.0	-0.009	-1000.0
PDGFR-alpha signaling pathway	109.0	4837.0	44.0	-0.227	0.037	1000.0	-1000.0	-0.055	-1000.0
IL12-mediated signaling events	89.0	7791.0	87.0	-0.445	0.115	1000.0	-1000.0	-0.119	-1000.0
Aurora B signaling	89.0	5979.0	67.0	-0.262	0.042	1000.0	-1000.0	-0.051	-1000.0
EGFR-dependent Endothelin signaling events	81.0	1714.0	21.0	-0.569	0.043	1000.0	-1000.0	-0.062	-1000.0
Glypican 1 network	80.0	3862.0	48.0	-0.402	0.046	1000.0	-1000.0	-0.047	-1000.0
Syndecan-4-mediated signaling events	77.0	5168.0	67.0	-0.437	0.089	1000.0	-1000.0	-0.07	-1000.0
amb2 Integrin signaling	70.0	5808.0	82.0	-0.456	0.038	1000.0	-1000.0	-0.056	-1000.0
FOXM1 transcription factor network	68.0	3470.0	51.0	-0.561	0.031	1000.0	-1000.0	-0.134	-1000.0
Aurora C signaling	67.0	471.0	7.0	-0.263	0.027	1000.0	-1000.0	-0.019	-1000.0
BMP receptor signaling	65.0	5319.0	81.0	-0.53	0.054	1000.0	-1000.0	-0.081	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	61.0	2034.0	33.0	-0.567	0.056	1000.0	-1000.0	-0.044	-1000.0
Glypican 2 network	59.0	238.0	4.0	-0.04	-1000.0	1000.0	-1000.0	0.002	-1000.0
IL4-mediated signaling events	58.0	5341.0	91.0	-0.786	0.488	1000.0	-1000.0	-0.108	-1000.0
JNK signaling in the CD4+ TCR pathway	55.0	948.0	17.0	-0.216	0.03	1000.0	-1000.0	-0.042	-1000.0
Caspase cascade in apoptosis	53.0	3941.0	74.0	-0.286	0.09	1000.0	-1000.0	-0.059	-1000.0
Syndecan-1-mediated signaling events	50.0	1705.0	34.0	-0.252	0.03	1000.0	-1000.0	-0.069	-1000.0
Fc-epsilon receptor I signaling in mast cells	47.0	4620.0	97.0	-0.232	0.041	1000.0	-1000.0	-0.089	-1000.0
HIF-2-alpha transcription factor network	40.0	1762.0	43.0	-0.524	0.241	1000.0	-1000.0	-0.067	-1000.0
Reelin signaling pathway	37.0	2109.0	56.0	-0.171	0.081	1000.0	-1000.0	-0.063	-1000.0
Effects of Botulinum toxin	37.0	985.0	26.0	-0.238	0.04	1000.0	-1000.0	-0.037	-1000.0
Calcium signaling in the CD4+ TCR pathway	37.0	1172.0	31.0	-0.37	0.029	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by the Hedgehog family	36.0	1873.0	52.0	-0.283	0.068	1000.0	-1000.0	-0.056	-1000.0
Arf6 signaling events	36.0	2266.0	62.0	-0.569	0.065	1000.0	-1000.0	-0.043	-1000.0
VEGFR1 specific signals	36.0	2061.0	56.0	-0.316	0.03	1000.0	-1000.0	-0.065	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	33.0	1835.0	54.0	-0.441	0.042	1000.0	-1000.0	-0.086	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	33.0	2281.0	68.0	-0.329	0.057	1000.0	-1000.0	-0.096	-1000.0
p75(NTR)-mediated signaling	32.0	4037.0	125.0	-0.309	0.079	1000.0	-1000.0	-0.097	-1000.0
PLK1 signaling events	32.0	2747.0	85.0	-0.196	0.043	1000.0	-1000.0	-0.038	-1000.0
IL27-mediated signaling events	32.0	1633.0	51.0	-0.589	0.059	1000.0	-1000.0	-0.064	-1000.0
IL2 signaling events mediated by STAT5	31.0	697.0	22.0	-0.297	0.036	1000.0	-1000.0	-0.066	-1000.0
Ephrin A  reverse signaling	30.0	212.0	7.0	-0.023	0.012	1000.0	-1000.0	-0.016	-1000.0
LPA4-mediated signaling events	29.0	359.0	12.0	-0.103	0.011	1000.0	-1000.0	-0.033	-1000.0
Coregulation of Androgen receptor activity	29.0	2212.0	76.0	-0.847	0.054	1000.0	-1000.0	-0.04	-1000.0
IL23-mediated signaling events	29.0	1782.0	60.0	-0.264	0.03	1000.0	-1000.0	-0.106	-1000.0
S1P1 pathway	27.0	985.0	36.0	-0.243	0.03	1000.0	-1000.0	-0.058	-1000.0
IL2 signaling events mediated by PI3K	24.0	1419.0	58.0	-0.295	0.047	1000.0	-1000.0	-0.06	-1000.0
BCR signaling pathway	24.0	2403.0	99.0	-0.214	0.056	1000.0	-1000.0	-0.091	-1000.0
Glucocorticoid receptor regulatory network	23.0	2657.0	114.0	-0.338	0.148	1000.0	-1000.0	-0.083	-1000.0
Wnt signaling	23.0	161.0	7.0	-0.045	0.028	1000.0	-1000.0	-0.024	-1000.0
Regulation of Telomerase	23.0	2425.0	102.0	-0.569	0.063	1000.0	-1000.0	-0.067	-1000.0
Signaling events mediated by PTP1B	22.0	1712.0	76.0	-0.571	0.066	1000.0	-1000.0	-0.058	-1000.0
Ceramide signaling pathway	22.0	1717.0	76.0	-0.569	0.207	1000.0	-1000.0	-0.058	-1000.0
FoxO family signaling	22.0	1463.0	64.0	-0.553	0.095	1000.0	-1000.0	-0.061	-1000.0
Integrins in angiogenesis	22.0	1891.0	84.0	-0.263	0.067	1000.0	-1000.0	-0.08	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	22.0	1727.0	78.0	-0.242	0.046	1000.0	-1000.0	-0.061	-1000.0
Noncanonical Wnt signaling pathway	21.0	565.0	26.0	-0.099	0.029	1000.0	-1000.0	-0.05	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	21.0	961.0	45.0	-0.365	0.078	1000.0	-1000.0	-0.075	-1000.0
Angiopoietin receptor Tie2-mediated signaling	21.0	1896.0	88.0	-0.203	0.044	1000.0	-1000.0	-0.082	-1000.0
Visual signal transduction: Rods	20.0	1064.0	52.0	-0.153	0.041	1000.0	-1000.0	-0.056	-1000.0
Syndecan-2-mediated signaling events	18.0	1275.0	69.0	-0.456	0.063	1000.0	-1000.0	-0.048	-1000.0
EPO signaling pathway	18.0	998.0	55.0	-0.167	0.035	1000.0	-1000.0	-0.076	-1000.0
Endothelins	18.0	1771.0	96.0	-0.333	0.048	1000.0	-1000.0	-0.075	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	18.0	2207.0	120.0	-0.113	0.081	1000.0	-1000.0	-0.071	-1000.0
Regulation of nuclear SMAD2/3 signaling	16.0	2201.0	136.0	-0.29	0.099	1000.0	-1000.0	-0.056	-1000.0
Thromboxane A2 receptor signaling	16.0	1768.0	105.0	-0.569	0.047	1000.0	-1000.0	-0.065	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	16.0	1203.0	74.0	-0.569	0.105	1000.0	-1000.0	-0.084	-1000.0
Presenilin action in Notch and Wnt signaling	15.0	915.0	61.0	-0.136	0.083	1000.0	-1000.0	-0.07	-1000.0
LPA receptor mediated events	15.0	1592.0	102.0	-0.252	0.052	1000.0	-1000.0	-0.077	-1000.0
IL6-mediated signaling events	15.0	1199.0	75.0	-0.221	0.059	1000.0	-1000.0	-0.063	-1000.0
Class I PI3K signaling events	15.0	1095.0	73.0	-0.298	0.079	1000.0	-1000.0	-0.059	-1000.0
Aurora A signaling	14.0	869.0	60.0	-0.153	0.063	1000.0	-1000.0	-0.039	-1000.0
IFN-gamma pathway	14.0	953.0	68.0	-0.244	0.042	1000.0	-1000.0	-0.091	-1000.0
S1P5 pathway	13.0	227.0	17.0	-0.072	0.029	1000.0	-1000.0	-0.033	-1000.0
Nongenotropic Androgen signaling	13.0	678.0	52.0	-0.112	0.045	1000.0	-1000.0	-0.049	-1000.0
Plasma membrane estrogen receptor signaling	13.0	1122.0	86.0	-0.149	0.053	1000.0	-1000.0	-0.085	-1000.0
PLK2 and PLK4 events	12.0	38.0	3.0	0.005	0.026	1000.0	-1000.0	-0.015	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	12.0	467.0	37.0	-0.172	0.058	1000.0	-1000.0	-0.059	-1000.0
FAS signaling pathway (CD95)	12.0	581.0	47.0	-0.28	0.049	1000.0	-1000.0	-0.043	-1000.0
Canonical Wnt signaling pathway	12.0	646.0	51.0	-0.136	0.096	1000.0	-1000.0	-0.067	-1000.0
S1P3 pathway	12.0	527.0	42.0	-0.241	0.052	1000.0	-1000.0	-0.045	-1000.0
Regulation of Androgen receptor activity	12.0	889.0	70.0	-0.914	0.054	1000.0	-1000.0	-0.073	-1000.0
Sphingosine 1-phosphate (S1P) pathway	11.0	308.0	28.0	-0.072	0.05	1000.0	-1000.0	-0.04	-1000.0
Signaling events regulated by Ret tyrosine kinase	11.0	957.0	82.0	-0.029	0.03	1000.0	-1000.0	-0.098	-1000.0
Signaling mediated by p38-alpha and p38-beta	11.0	497.0	44.0	-0.038	0.055	1000.0	-1000.0	-0.042	-1000.0
TCGA08_rtk_signaling	11.0	295.0	26.0	-0.227	0.057	1000.0	-1000.0	-0.025	-1000.0
ErbB4 signaling events	10.0	733.0	69.0	-0.159	0.095	1000.0	-1000.0	-0.064	-1000.0
S1P4 pathway	10.0	250.0	25.0	-0.072	0.039	1000.0	-1000.0	-0.046	-1000.0
E-cadherin signaling events	10.0	54.0	5.0	0.007	0.025	1000.0	-1000.0	-0.003	-1000.0
a4b1 and a4b7 Integrin signaling	9.0	45.0	5.0	0.01	0.029	1000.0	-1000.0	-0.004	-1000.0
Syndecan-3-mediated signaling events	9.0	345.0	35.0	-0.012	0.079	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	9.0	1206.0	125.0	-0.24	0.044	1000.0	-1000.0	-0.078	-1000.0
ceramide signaling pathway	8.0	436.0	49.0	-0.066	0.045	1000.0	-1000.0	-0.062	-1000.0
Visual signal transduction: Cones	7.0	294.0	38.0	-0.013	0.045	1000.0	-1000.0	-0.023	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	7.0	671.0	85.0	-0.039	0.084	1000.0	-1000.0	-0.064	-1000.0
mTOR signaling pathway	7.0	382.0	53.0	-0.063	0.053	1000.0	-1000.0	-0.059	-1000.0
Ephrin B reverse signaling	7.0	355.0	48.0	-0.049	0.054	1000.0	-1000.0	-0.047	-1000.0
Canonical NF-kappaB pathway	6.0	259.0	39.0	-0.115	0.057	1000.0	-1000.0	-0.07	-1000.0
IL1-mediated signaling events	6.0	398.0	62.0	-0.042	0.065	1000.0	-1000.0	-0.084	-1000.0
E-cadherin signaling in the nascent adherens junction	6.0	474.0	76.0	-0.033	0.051	1000.0	-1000.0	-0.086	-1000.0
Signaling events mediated by PRL	6.0	212.0	34.0	-0.046	0.062	1000.0	-1000.0	-0.061	-1000.0
ErbB2/ErbB3 signaling events	5.0	348.0	65.0	-0.129	0.042	1000.0	-1000.0	-0.062	-1000.0
Cellular roles of Anthrax toxin	5.0	204.0	39.0	-0.01	0.039	1000.0	-1000.0	-0.031	-1000.0
Insulin-mediated glucose transport	5.0	180.0	32.0	-0.043	0.057	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by HDAC Class III	5.0	222.0	40.0	-0.054	0.055	1000.0	-1000.0	-0.025	-1000.0
EPHB forward signaling	5.0	467.0	85.0	-0.053	0.075	1000.0	-1000.0	-0.093	-1000.0
PDGFR-beta signaling pathway	5.0	493.0	97.0	-0.016	0.086	1000.0	-1000.0	-0.081	-1000.0
Class IB PI3K non-lipid kinase events	5.0	15.0	3.0	-0.023	0.023	1000.0	-1000.0	-0.003	-1000.0
p38 MAPK signaling pathway	5.0	246.0	44.0	-0.065	0.057	1000.0	-1000.0	-0.05	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	99.0	17.0	-0.01	0.054	1000.0	-1000.0	-0.036	-1000.0
Regulation of p38-alpha and p38-beta	4.0	246.0	54.0	-0.022	0.067	1000.0	-1000.0	-0.067	-1000.0
Arf6 trafficking events	4.0	301.0	71.0	-0.118	0.061	1000.0	-1000.0	-0.044	-1000.0
E-cadherin signaling in keratinocytes	4.0	208.0	43.0	-0.22	0.042	1000.0	-1000.0	-0.055	-1000.0
BARD1 signaling events	3.0	220.0	57.0	-0.097	0.076	1000.0	-1000.0	-0.073	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	218.0	65.0	-0.007	0.103	1000.0	-1000.0	-0.065	-1000.0
Class I PI3K signaling events mediated by Akt	3.0	218.0	68.0	-0.043	0.056	1000.0	-1000.0	-0.053	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	3.0	178.0	52.0	-0.014	0.099	1000.0	-1000.0	-0.046	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	57.0	15.0	-0.0	0.031	1000.0	-1000.0	-0.045	-1000.0
Insulin Pathway	3.0	286.0	74.0	-0.032	0.08	1000.0	-1000.0	-0.08	-1000.0
Osteopontin-mediated events	2.0	95.0	38.0	-0.0	0.087	1000.0	-1000.0	-0.074	-1000.0
Arf6 downstream pathway	2.0	122.0	43.0	-0.048	0.049	1000.0	-1000.0	-0.034	-1000.0
Nectin adhesion pathway	2.0	153.0	63.0	0.0	0.058	1000.0	-1000.0	-0.07	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	223.0	83.0	-0.043	0.074	1000.0	-1000.0	-0.064	-1000.0
Retinoic acid receptors-mediated signaling	2.0	123.0	58.0	-0.014	0.053	1000.0	-1000.0	-0.052	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	72.0	36.0	-0.052	0.055	1000.0	-1000.0	-0.072	-1000.0
IGF1 pathway	2.0	136.0	57.0	-0.048	0.078	1000.0	-1000.0	-0.089	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	23.0	23.0	-0.027	0.056	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by HDAC Class II	1.0	110.0	75.0	-0.041	0.063	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by HDAC Class I	1.0	177.0	104.0	-0.057	0.075	1000.0	-1000.0	-0.053	-1000.0
Atypical NF-kappaB pathway	1.0	60.0	31.0	-0.0	0.037	1000.0	-1000.0	-0.047	-1000.0
Arf1 pathway	1.0	73.0	54.0	-0.0	0.05	1000.0	-1000.0	-0.032	-1000.0
Circadian rhythm pathway	0.0	21.0	22.0	-0.014	0.069	1000.0	-1000.0	-0.04	-1000.0
TRAIL signaling pathway	0.0	33.0	48.0	-0.0	0.072	1000.0	-1000.0	-0.053	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	-0.0	0.07	1000.0	-1000.0	-0.056	-1000.0
Rapid glucocorticoid signaling	0.0	8.0	20.0	-0.007	0.036	1000.0	-1000.0	-0.009	-1000.0
Alternative NF-kappaB pathway	0.0	10.0	13.0	-0.0	0.062	1000.0	-1000.0	-0.007	-1000.0
Total	3559	192991	7203	-29.7304388464	-991.536218612	131000	-131000	-7.64949684813	-131000