Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.126 0.19 -9999.0 0.0 -0.512 10.0 10.0 IHH -0.08 0.137 -9999.0 0.0 -0.296 17.0 17.0 SHH Np/Cholesterol/GAS1 0.029 0.045 -9999.0 0.0 -9999.0 0.0 0.0 LRPAP1 0.044 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.028 0.045 -9999.0 0.0 -9999.0 0.0 0.0 SMO/beta Arrestin2 -0.051 0.168 -9999.0 0.0 -0.443 5.0 5.0 SMO -0.079 0.16 -9999.0 0.0 -0.435 7.0 7.0 AKT1 -0.031 0.17 -9999.0 0.0 -0.592 5.0 5.0 ARRB2 0.04 0.012 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.029 0.078 -9999.0 0.0 -0.425 2.0 2.0 ADRBK1 0.044 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.077 0.158 -9999.0 0.0 -0.429 7.0 7.0 STIL -0.042 0.106 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH2 0.047 0.063 -9999.0 0.0 -0.301 2.0 2.0 DHH N/PTCH1 -0.069 0.122 -9999.0 0.0 -0.276 10.0 10.0 PIK3CA 0.043 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.03 0.078 -9999.0 0.0 -0.425 2.0 2.0 PTHLH -0.208 0.339 -9999.0 0.0 -0.934 11.0 11.0 determination of left/right symmetry -0.077 0.158 -9999.0 0.0 -0.429 7.0 7.0 PIK3R1 0.009 0.115 -9999.0 0.0 -0.4 5.0 5.0 skeletal system development -0.205 0.334 -9999.0 0.0 -0.921 11.0 11.0 IHH N/Hhip -0.056 0.137 -9999.0 0.0 -0.273 15.0 15.0 DHH N/Hhip 0.011 0.129 -9999.0 0.0 -0.267 11.0 11.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.077 0.158 -9999.0 0.0 -0.429 7.0 7.0 pancreas development -0.014 0.134 -9999.0 0.0 -0.321 11.0 11.0 HHAT 0.039 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.036 0.09 -9999.0 0.0 -0.281 5.0 5.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.028 0.07 -9999.0 0.0 -0.299 3.0 3.0 somite specification -0.077 0.158 -9999.0 0.0 -0.429 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.055 0.099 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH2 0.037 0.025 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin 0.005 0.088 -9999.0 0.0 -0.228 8.0 8.0 SHH 0.02 0.025 -9999.0 0.0 -0.172 1.0 1.0 catabolic process -0.082 0.123 -9999.0 0.0 -0.301 10.0 10.0 SMO/Vitamin D3 -0.064 0.13 -9999.0 0.0 -0.369 3.0 3.0 SHH Np/Cholesterol/Hhip 0.011 0.074 -9999.0 0.0 -0.228 2.0 2.0 LRP2 -0.026 0.163 -9999.0 0.0 -0.425 10.0 10.0 receptor-mediated endocytosis -0.08 0.158 -9999.0 0.0 -0.375 10.0 10.0 SHH Np/Cholesterol/BOC 0.029 0.052 -9999.0 0.0 -0.228 2.0 2.0 SHH Np/Cholesterol/CDO 0.017 0.079 -9999.0 0.0 -0.229 6.0 6.0 mesenchymal cell differentiation -0.01 0.074 0.227 2.0 -9999.0 0.0 2.0 mol:Vitamin D3 -0.043 0.116 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH2 -0.015 0.092 -9999.0 0.0 -0.189 5.0 5.0 CDON -0.008 0.145 -9999.0 0.0 -0.409 8.0 8.0 IHH N/PTCH1 -0.08 0.13 -9999.0 0.0 -0.303 10.0 10.0 Megalin/LRPAP1 0.008 0.127 -9999.0 0.0 -0.301 10.0 10.0 PTCH2 0.04 0.013 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.022 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 -0.083 0.124 -9999.0 0.0 -0.302 10.0 10.0 HHIP -0.014 0.134 -9999.0 0.0 -0.322 11.0 11.0