Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.017 0.099 -9999.0 0.0 -0.234 10.0 10.0 epithelial cell differentiation 0.01 0.106 -9999.0 0.0 -0.213 9.0 9.0 CYFIP2 0.028 0.057 -9999.0 0.0 -0.425 1.0 1.0 ENAH 0.015 0.157 0.541 2.0 -0.293 4.0 6.0 EGFR -0.024 0.151 -9999.0 0.0 -0.368 11.0 11.0 EPHA2 0.028 0.069 -9999.0 0.0 -0.362 2.0 2.0 MYO6 0.036 0.146 0.707 1.0 -0.228 8.0 9.0 CTNNB1 0.033 0.019 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.055 0.06 -9999.0 0.0 -0.253 1.0 1.0 AQP5 0.02 0.153 -9999.0 0.0 -0.646 2.0 2.0 CTNND1 0.024 0.095 -9999.0 0.0 -0.425 3.0 3.0 mol:PI-4-5-P2 0.034 0.142 0.704 1.0 -9999.0 0.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.026 0.164 -9999.0 0.0 -0.3 11.0 11.0 EGF -0.126 0.195 -9999.0 0.0 -0.339 31.0 31.0 NCKAP1 0.036 0.042 -9999.0 0.0 -0.299 1.0 1.0 AQP3 -0.018 0.201 -9999.0 0.0 -0.637 5.0 5.0 cortical microtubule organization 0.01 0.106 -9999.0 0.0 -0.213 9.0 9.0 GO:0000145 0.021 0.136 0.256 8.0 -9999.0 0.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.014 0.11 -9999.0 0.0 -0.214 9.0 9.0 MLLT4 0.032 0.057 -9999.0 0.0 -0.425 1.0 1.0 ARF6/GDP -0.044 0.104 -9999.0 0.0 -0.373 4.0 4.0 ARF6 0.041 0.011 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.056 0.122 -9999.0 0.0 -0.292 6.0 6.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.007 0.116 0.212 5.0 -0.258 3.0 8.0 PVRL2 0.044 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.02 0.115 -9999.0 0.0 -0.204 8.0 8.0 ARF6/GTP 0.063 0.12 -9999.0 0.0 -0.309 4.0 4.0 CDH1 -0.022 0.152 -9999.0 0.0 -0.368 11.0 11.0 EGFR/EGFR/EGF/EGF -0.089 0.143 -9999.0 0.0 -0.34 10.0 10.0 RhoA/GDP 0.013 0.104 -9999.0 0.0 -0.202 9.0 9.0 actin cytoskeleton organization 0.018 0.114 0.191 7.0 -0.385 1.0 8.0 IGF-1R heterotetramer 0.037 0.056 -9999.0 0.0 -0.424 1.0 1.0 GIT1 0.04 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.038 0.056 -9999.0 0.0 -0.425 1.0 1.0 IGF1 -0.017 0.139 -9999.0 0.0 -0.333 11.0 11.0 DIAPH1 0.011 0.194 -9999.0 0.0 -0.654 2.0 2.0 Wnt receptor signaling pathway -0.01 0.106 0.213 9.0 -9999.0 0.0 9.0 RHOA 0.034 0.019 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.044 0.105 -9999.0 0.0 -0.372 4.0 4.0 CTNNA1 0.035 0.018 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.018 0.116 0.193 7.0 -0.395 1.0 8.0 EFNA1 -0.008 0.14 -9999.0 0.0 -0.425 7.0 7.0 LPP -0.009 0.132 0.205 5.0 -0.339 3.0 8.0 Ephrin A1/EPHA2 -0.016 0.126 -9999.0 0.0 -0.36 4.0 4.0 SEC6/SEC8 -0.019 0.077 -9999.0 0.0 -0.346 1.0 1.0 MGAT3 -0.026 0.166 -9999.0 0.0 -0.305 11.0 11.0 HGF/MET -0.008 0.101 -9999.0 0.0 -0.256 1.0 1.0 HGF 0.019 0.088 -9999.0 0.0 -0.33 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.017 0.099 -9999.0 0.0 -0.236 10.0 10.0 actin cable formation 0.048 0.18 0.326 10.0 -0.356 3.0 13.0 KIAA1543 0.011 0.111 0.196 7.0 -9999.0 0.0 7.0 KIFC3 0.023 0.119 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.036 0.056 -9999.0 0.0 -0.425 1.0 1.0 EXOC3 0.034 0.056 -9999.0 0.0 -0.425 1.0 1.0 ACTN1 0.002 0.139 -9999.0 0.0 -0.243 12.0 12.0 NCK1/GIT1 0.054 0.049 -9999.0 0.0 -0.318 1.0 1.0 mol:GDP 0.01 0.106 -9999.0 0.0 -0.213 9.0 9.0 EXOC4 0.04 0.012 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.015 0.131 -9999.0 0.0 -0.4 2.0 2.0 PIP5K1C 0.034 0.144 0.707 1.0 -9999.0 0.0 1.0 LIMA1 0.017 0.096 -9999.0 0.0 -0.324 5.0 5.0 ABI1 0.041 0.011 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.03 0.175 0.482 3.0 -0.329 4.0 7.0 adherens junction assembly 0.044 0.156 0.949 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer/IGF1 -0.013 0.124 -9999.0 0.0 -0.322 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.052 0.048 -9999.0 0.0 -0.301 1.0 1.0 MET 0.028 0.069 -9999.0 0.0 -0.362 2.0 2.0 PLEKHA7 0.024 0.119 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.053 0.12 -9999.0 0.0 -0.29 6.0 6.0 establishment of epithelial cell apical/basal polarity 0.034 0.146 0.398 3.0 -0.499 1.0 4.0 cortical actin cytoskeleton stabilization -0.017 0.099 -9999.0 0.0 -0.234 10.0 10.0 regulation of cell-cell adhesion 0.018 0.114 0.191 7.0 -0.385 1.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.017 0.099 -9999.0 0.0 -0.236 10.0 10.0