Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.048 0.094 -9999.0 0.0 -0.203 4.0 4.0 epithelial cell differentiation 0.006 0.107 -9999.0 0.0 -0.206 3.0 3.0 CYFIP2 0.029 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.044 0.204 0.7 1.0 -9999.0 0.0 1.0 EGFR -0.037 0.13 -9999.0 0.0 -0.282 3.0 3.0 EPHA2 0.027 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.043 0.128 0.334 1.0 -9999.0 0.0 1.0 CTNNB1 -0.046 0.155 -9999.0 0.0 -0.369 3.0 3.0 ABI1/Sra1/Nap1 0.057 0.024 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.041 0.072 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.043 0.127 0.332 1.0 -9999.0 0.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.043 0.127 0.332 1.0 -9999.0 0.0 1.0 EGF -0.022 0.104 -9999.0 0.0 -0.173 4.0 4.0 NCKAP1 0.022 0.034 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.075 0.154 -9999.0 0.0 -0.461 2.0 2.0 cortical microtubule organization 0.006 0.107 -9999.0 0.0 -0.206 3.0 3.0 GO:0000145 -0.042 0.12 0.313 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.01 0.11 -9999.0 0.0 -0.208 3.0 3.0 MLLT4 0.029 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.091 0.066 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.01 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.054 0.046 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.048 0.088 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.053 0.09 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.07 0.051 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.015 0.102 -9999.0 0.0 -0.369 1.0 1.0 EGFR/EGFR/EGF/EGF -0.096 0.12 -9999.0 0.0 -0.255 5.0 5.0 RhoA/GDP -0.015 0.119 -9999.0 0.0 -0.213 4.0 4.0 actin cytoskeleton organization -0.049 0.123 0.309 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer 0.029 0.007 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.029 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.029 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.022 0.034 -9999.0 0.0 -9999.0 0.0 0.0 DIAPH1 0.014 0.145 -9999.0 0.0 -0.54 1.0 1.0 Wnt receptor signaling pathway -0.006 0.107 0.206 3.0 -9999.0 0.0 3.0 RHOA 0.004 0.097 -9999.0 0.0 -0.369 1.0 1.0 RhoA/GTP -0.101 0.078 -9999.0 0.0 -0.235 2.0 2.0 CTNNA1 0.029 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.05 0.124 0.311 1.0 -9999.0 0.0 1.0 EFNA1 0.027 0.01 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.07 0.08 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.019 0.103 -9999.0 0.0 -0.209 3.0 3.0 SEC6/SEC8 -0.073 0.076 -9999.0 0.0 -0.213 3.0 3.0 MGAT3 -0.043 0.128 0.334 1.0 -9999.0 0.0 1.0 HGF/MET -0.026 0.083 -9999.0 0.0 -0.209 2.0 2.0 HGF 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.048 0.094 -9999.0 0.0 -0.205 4.0 4.0 actin cable formation 0.003 0.227 0.494 2.0 -0.269 1.0 3.0 KIAA1543 -0.038 0.121 0.316 1.0 -9999.0 0.0 1.0 KIFC3 -0.085 0.074 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.029 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.043 0.127 0.334 1.0 -9999.0 0.0 1.0 NCK1/GIT1 0.043 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.006 0.107 -9999.0 0.0 -0.206 3.0 3.0 EXOC4 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.073 0.068 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.044 0.129 0.334 1.0 -9999.0 0.0 1.0 LIMA1 0.006 0.097 -9999.0 0.0 -0.369 1.0 1.0 ABI1 0.029 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.039 0.22 0.739 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.037 0.168 0.341 2.0 -0.298 1.0 3.0 IGF-1R heterotetramer/IGF1 -0.023 0.106 -9999.0 0.0 -0.216 3.0 3.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.043 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.019 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.039 0.129 0.334 1.0 -9999.0 0.0 1.0 mol:GTP 0.052 0.044 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.044 0.113 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.048 0.094 -9999.0 0.0 -0.203 4.0 4.0 regulation of cell-cell adhesion -0.049 0.123 0.309 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.048 0.094 -9999.0 0.0 -0.205 4.0 4.0