E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.095 0.188 -9999.0 0.0 -0.475 28.0 28.0 KLHL20 -0.04 0.098 -9999.0 0.0 -0.198 34.0 34.0 CYFIP2 0.013 0.043 -9999.0 0.0 -0.381 2.0 2.0 Rac1/GDP -0.038 0.117 -9999.0 0.0 -0.229 35.0 35.0 ENAH -0.092 0.173 -9999.0 0.0 -0.426 30.0 30.0 AP1M1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.05 0.073 -9999.0 0.0 -0.239 14.0 14.0 ABI1/Sra1/Nap1 -0.05 0.061 -9999.0 0.0 -0.149 40.0 40.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.03 0.101 -9999.0 0.0 -0.199 32.0 32.0 RAPGEF1 -0.059 0.15 -9999.0 0.0 -0.351 30.0 30.0 CTNND1 0.008 0.06 -9999.0 0.0 -0.381 4.0 4.0 regulation of calcium-dependent cell-cell adhesion -0.068 0.167 -9999.0 0.0 -0.413 29.0 29.0 CRK -0.069 0.162 -9999.0 0.0 -0.374 32.0 32.0 E-cadherin/gamma catenin/alpha catenin -0.064 0.126 -9999.0 0.0 -0.244 43.0 43.0 alphaE/beta7 Integrin 0.011 0.056 -9999.0 0.0 -0.199 11.0 11.0 IQGAP1 0.015 0.03 -9999.0 0.0 -0.381 1.0 1.0 NCKAP1 -0.046 0.132 -9999.0 0.0 -0.313 33.0 33.0 Rap1/GTP/I-afadin 0.004 0.065 -9999.0 0.0 -0.186 9.0 9.0 DLG1 -0.06 0.162 -9999.0 0.0 -0.403 28.0 28.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.036 0.054 -9999.0 0.0 -0.188 11.0 11.0 MLLT4 -0.037 0.121 -9999.0 0.0 -0.298 30.0 30.0 ARF6/GTP/NME1/Tiam1 0.003 0.068 -9999.0 0.0 -0.186 12.0 12.0 PI3K -0.045 0.068 -9999.0 0.0 -0.242 11.0 11.0 ARF6 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.083 0.142 -9999.0 0.0 -0.239 71.0 71.0 TIAM1 -0.04 0.126 -9999.0 0.0 -0.31 30.0 30.0 E-cadherin(dimer)/Ca2+ -0.028 0.093 -9999.0 0.0 -0.179 34.0 34.0 AKT1 -0.023 0.042 -9999.0 0.0 -0.141 10.0 10.0 PIK3R1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.098 0.163 -9999.0 0.0 -0.319 59.0 59.0 RhoA/GDP -0.037 0.117 -9999.0 0.0 -0.229 35.0 35.0 actin cytoskeleton organization -0.028 0.073 -9999.0 0.0 -0.145 34.0 34.0 CDC42/GDP -0.037 0.117 -9999.0 0.0 -0.243 28.0 28.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.057 0.117 -9999.0 0.0 -0.226 46.0 46.0 ITGB7 0.005 0.066 -9999.0 0.0 -0.342 6.0 6.0 RAC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.03 0.1 -9999.0 0.0 -0.191 34.0 34.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.032 0.087 -9999.0 0.0 -0.18 31.0 31.0 mol:GDP -0.052 0.131 -9999.0 0.0 -0.267 36.0 36.0 CDC42/GTP/IQGAP1 0.022 0.018 -9999.0 0.0 -0.214 1.0 1.0 JUP -0.026 0.123 -9999.0 0.0 -0.375 19.0 19.0 p120 catenin/RhoA/GDP -0.038 0.12 -9999.0 0.0 -0.248 29.0 29.0 RAC1/GTP/IQGAP1 0.022 0.018 -9999.0 0.0 -0.214 1.0 1.0 PIP5K1C/AP1M1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.008 0.06 -9999.0 0.0 -0.381 4.0 4.0 positive regulation of S phase of mitotic cell cycle -0.027 0.068 -9999.0 0.0 -0.13 40.0 40.0 NME1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.084 0.166 -9999.0 0.0 -0.415 29.0 29.0 regulation of cell-cell adhesion -0.045 0.065 -9999.0 0.0 -0.211 14.0 14.0 WASF2 -0.024 0.033 -9999.0 0.0 -0.098 13.0 13.0 Rap1/GTP -0.033 0.103 -9999.0 0.0 -0.261 16.0 16.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.046 0.12 -9999.0 0.0 -0.212 46.0 46.0 CCND1 -0.033 0.082 -9999.0 0.0 -0.161 39.0 39.0 VAV2 -0.103 0.217 -9999.0 0.0 -0.457 40.0 40.0 RAP1/GDP -0.035 0.108 -9999.0 0.0 -0.272 15.0 15.0 adherens junction assembly -0.082 0.161 -9999.0 0.0 -0.402 29.0 29.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.039 0.114 -9999.0 0.0 -0.298 15.0 15.0 E-cadherin/beta catenin -0.052 0.111 -9999.0 0.0 -0.285 28.0 28.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.079 0.171 -9999.0 0.0 -0.402 32.0 32.0 PIK3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.096 0.131 -9999.0 0.0 -0.318 35.0 35.0 E-cadherin/beta catenin/alpha catenin -0.039 0.103 -9999.0 0.0 -0.214 31.0 31.0 ITGAE 0.009 0.047 -9999.0 0.0 -0.262 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.069 0.17 -9999.0 0.0 -0.422 29.0 29.0