Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.026 0.132 -9999.0 0.0 -0.384 12.0 12.0 IHH -0.01 0.065 -9999.0 0.0 -0.289 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.018 0.08 -9999.0 0.0 -0.161 38.0 38.0 LRPAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.018 0.079 0.16 38.0 -9999.0 0.0 38.0 SMO/beta Arrestin2 -0.052 0.145 -9999.0 0.0 -0.447 10.0 10.0 SMO -0.063 0.151 -9999.0 0.0 -0.428 13.0 13.0 AKT1 -0.008 0.073 -9999.0 0.0 -0.256 2.0 2.0 ARRB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.013 0.037 -9999.0 0.0 -0.322 2.0 2.0 ADRBK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.062 0.149 -9999.0 0.0 -0.421 13.0 13.0 STIL -0.023 0.115 -9999.0 0.0 -0.293 16.0 16.0 DHH N/PTCH2 0.016 0.042 -9999.0 0.0 -0.224 5.0 5.0 DHH N/PTCH1 -0.027 0.127 -9999.0 0.0 -0.337 14.0 14.0 PIK3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.01 0.03 -9999.0 0.0 -0.262 2.0 2.0 PTHLH -0.026 0.135 -9999.0 0.0 -0.438 10.0 10.0 determination of left/right symmetry -0.062 0.149 -9999.0 0.0 -0.421 13.0 13.0 PIK3R1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.026 0.134 -9999.0 0.0 -0.435 10.0 10.0 IHH N/Hhip -0.044 0.109 -9999.0 0.0 -0.238 38.0 38.0 DHH N/Hhip -0.029 0.096 -9999.0 0.0 -0.204 38.0 38.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.062 0.149 -9999.0 0.0 -0.421 13.0 13.0 pancreas development -0.054 0.133 -9999.0 0.0 -0.303 37.0 37.0 HHAT 0.003 0.073 -9999.0 0.0 -0.381 6.0 6.0 PI3K 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.041 0.127 -9999.0 0.0 -0.32 29.0 29.0 somite specification -0.062 0.149 -9999.0 0.0 -0.421 13.0 13.0 SHH Np/Cholesterol/PTCH1 -0.027 0.12 -9999.0 0.0 -0.313 16.0 16.0 SHH Np/Cholesterol/PTCH2 0.009 0.052 -9999.0 0.0 -0.189 9.0 9.0 SHH Np/Cholesterol/Megalin 0.001 0.056 -9999.0 0.0 -0.165 12.0 12.0 SHH 0.003 0.059 -9999.0 0.0 -0.217 11.0 11.0 catabolic process -0.037 0.14 -9999.0 0.0 -0.302 29.0 29.0 SMO/Vitamin D3 -0.045 0.13 -9999.0 0.0 -0.359 16.0 16.0 SHH Np/Cholesterol/Hhip -0.025 0.082 -9999.0 0.0 -0.18 28.0 28.0 LRP2 -0.003 0.064 -9999.0 0.0 -0.262 10.0 10.0 receptor-mediated endocytosis -0.037 0.133 -9999.0 0.0 -0.402 12.0 12.0 SHH Np/Cholesterol/BOC 0.01 0.048 -9999.0 0.0 -0.188 7.0 7.0 SHH Np/Cholesterol/CDO -0.01 0.073 -9999.0 0.0 -0.192 18.0 18.0 mesenchymal cell differentiation 0.025 0.082 0.179 28.0 -9999.0 0.0 28.0 mol:Vitamin D3 -0.026 0.121 -9999.0 0.0 -0.313 16.0 16.0 IHH N/PTCH2 0.005 0.053 -9999.0 0.0 -0.241 5.0 5.0 CDON -0.026 0.108 -9999.0 0.0 -0.292 24.0 24.0 IHH N/PTCH1 -0.035 0.142 -9999.0 0.0 -0.303 29.0 29.0 Megalin/LRPAP1 0.011 0.044 -9999.0 0.0 -0.166 10.0 10.0 PTCH2 0.01 0.052 -9999.0 0.0 -0.381 3.0 3.0 SHH Np/Cholesterol 0.003 0.044 -9999.0 0.0 -0.161 11.0 11.0 PTCH1 -0.037 0.141 -9999.0 0.0 -0.302 29.0 29.0 HHIP -0.054 0.133 -9999.0 0.0 -0.304 37.0 37.0