Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.022 0.071 -9999.0 0.0 -0.356 5.0 5.0 IHH 0.034 0.037 -9999.0 0.0 -0.147 5.0 5.0 SHH Np/Cholesterol/GAS1 0.004 0.058 -9999.0 0.0 -0.175 15.0 15.0 LRPAP1 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.004 0.057 0.174 15.0 -9999.0 0.0 15.0 SMO/beta Arrestin2 -0.008 0.129 -9999.0 0.0 -0.455 6.0 6.0 SMO -0.015 0.121 -9999.0 0.0 -0.51 5.0 5.0 AKT1 0.017 0.068 -9999.0 0.0 -0.426 1.0 1.0 ARRB2 0.029 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.028 0.029 -9999.0 0.0 -0.335 1.0 1.0 ADRBK1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.014 0.119 -9999.0 0.0 -0.502 5.0 5.0 STIL 0.007 0.065 0.182 1.0 -0.312 5.0 6.0 DHH N/PTCH2 0.039 0.032 -9999.0 0.0 -0.235 2.0 2.0 DHH N/PTCH1 0.033 0.071 -9999.0 0.0 -0.361 5.0 5.0 PIK3CA 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.017 0.085 -9999.0 0.0 -0.445 5.0 5.0 determination of left/right symmetry -0.014 0.119 -9999.0 0.0 -0.502 5.0 5.0 PIK3R1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.017 0.085 -9999.0 0.0 -0.442 5.0 5.0 IHH N/Hhip 0.019 0.079 -9999.0 0.0 -0.258 11.0 11.0 DHH N/Hhip 0.02 0.069 -9999.0 0.0 -0.235 11.0 11.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.014 0.119 -9999.0 0.0 -0.502 5.0 5.0 pancreas development 0.0 0.09 -9999.0 0.0 -0.335 11.0 11.0 HHAT 0.025 0.049 -9999.0 0.0 -0.335 3.0 3.0 PI3K 0.045 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.0 0.094 -9999.0 0.0 -0.335 12.0 12.0 somite specification -0.014 0.119 -9999.0 0.0 -0.502 5.0 5.0 SHH Np/Cholesterol/PTCH1 0.015 0.064 -9999.0 0.0 -0.296 6.0 6.0 SHH Np/Cholesterol/PTCH2 0.02 0.036 -9999.0 0.0 -0.174 5.0 5.0 SHH Np/Cholesterol/Megalin 0.019 0.027 -9999.0 0.0 -0.163 3.0 3.0 SHH -0.001 0.029 -9999.0 0.0 -0.235 2.0 2.0 catabolic process 0.013 0.074 -9999.0 0.0 -0.401 5.0 5.0 SMO/Vitamin D3 -0.006 0.088 -9999.0 0.0 -0.432 5.0 5.0 SHH Np/Cholesterol/Hhip 0.003 0.056 -9999.0 0.0 -0.175 14.0 14.0 LRP2 0.026 0.01 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis 0.001 0.092 -9999.0 0.0 -0.473 5.0 5.0 SHH Np/Cholesterol/BOC 0.02 0.032 -9999.0 0.0 -0.166 4.0 4.0 SHH Np/Cholesterol/CDO 0.015 0.041 -9999.0 0.0 -0.174 7.0 7.0 mesenchymal cell differentiation -0.003 0.055 0.174 14.0 -9999.0 0.0 14.0 mol:Vitamin D3 0.014 0.068 0.194 3.0 -0.325 5.0 8.0 IHH N/PTCH2 0.041 0.043 -9999.0 0.0 -0.26 2.0 2.0 CDON 0.018 0.057 -9999.0 0.0 -0.335 4.0 4.0 IHH N/PTCH1 0.023 0.077 -9999.0 0.0 -0.403 5.0 5.0 Megalin/LRPAP1 0.042 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.027 0.04 -9999.0 0.0 -0.335 2.0 2.0 SHH Np/Cholesterol 0.016 0.027 -9999.0 0.0 -0.167 3.0 3.0 PTCH1 0.013 0.075 -9999.0 0.0 -0.402 5.0 5.0 HHIP 0.0 0.09 -9999.0 0.0 -0.335 11.0 11.0