Clinical Features	MRNA_CNMF		MRNA_CHIERARCHICAL		CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Chi-square test_P	Chi-square test_Q	Fisher's exact test_P	Fisher's exact test_Q	Chi-square test_P	Chi-square test_Q	Fisher's exact test_P	Fisher's exact test_Q	Chi-square test_P	Chi-square test_Q	Fisher's exact test_P	Fisher's exact test_Q
NOTCH1	29 (10%)	260	0.46346	1	0.22308	1	0.00016729	0.0341	3.0211e-08	6.59e-06	0.87531	1	0.23056	1	0.00012772	0.0263	8.0551e-06	0.00172	0.0024191	0.464	0.0001603	0.0329	0.0071959	1	0.00011478	0.0238
PIK3CA	25 (9%)	264	NA	NA	NA	NA	0.00028105	0.0565	8.219e-06	0.00174	0.56626	1	0.10701	1	0.038282	1	0.03368	1	0.11241	1	0.71358	1	0.029771	1	0.71016	1
IDH2	12 (4%)	277	NA	NA	NA	NA	0.11087	1	0.0054946	1	0.51689	1	1	1	0.015624	1	0.00028442	0.0569	0.016236	1	0.10974	1	0.17592	1	0.080784	1
IDH1	220 (76%)	69	0.27157	1	0.52308	1	2.3243e-16	5.44e-14	9.6021e-40	2.35e-37	3.1452e-07	6.83e-05	0.030786	1	3.0619e-21	7.26e-19	0.0049834	0.937	0.033207	1	0.55523	1	6.7022e-16	1.55e-13	1.272e-05	0.00268
TP53	146 (51%)	143	0.062668	1	0.0075361	1	1.1325e-22	2.71e-20	1.4436e-52	3.55e-50	0.029636	1	0.6562	1	3.6759e-25	8.9e-23	1.9926e-17	4.68e-15	0.00018428	0.0374	0.00034955	0.0696	3.1643e-13	7.31e-11	5.0689e-05	0.0106
STK19	8 (3%)	281	NA	NA	NA	NA	0.38034	1	0.15893	1	0.01827	1	0.012069	1	0.71393	1	0.55576	1	0.35606	1	0.75012	1	0.46905	1	0.7895	1
CIC	54 (19%)	235	0.042805	1	0.0030328	0.579	1.16e-23	2.8e-21	5.3965e-32	1.31e-29	7.2497e-05	0.0151	0.19168	1	1.179e-23	2.83e-21	1.19e-22	2.83e-20	1.6219e-05	0.00341	0.014762	1	1.0244e-09	2.26e-07	0.0043469	0.822
ATRX	114 (39%)	175	0.018541	1	0.057243	1	6.5175e-16	1.52e-13	7.4448e-38	1.82e-35	0.2732	1	0.83781	1	9.7977e-18	2.31e-15	8.2964e-10	1.84e-07	0.0088072	1	0.011338	1	1.0017e-06	0.000215	0.006696	1
FUBP1	26 (9%)	263	0.024816	1	0.0059532	1	3.2067e-12	7.38e-10	5.3702e-11	1.22e-08	0.018819	1	0.16762	1	6.5534e-10	1.47e-07	3.9768e-11	9.07e-09	0.0015479	0.3	0.41923	1	0.02957	1	0.099184	1
EGFR	17 (6%)	272	NA	NA	NA	NA	7.7901e-10	1.74e-07	2.3837e-11	5.46e-09	0.0075391	1	0.12054	1	4.5525e-07	9.83e-05	0.090359	1	0.42744	1	1	1	0.00025891	0.0523	0.00898	1
PIK3R1	13 (4%)	276	0.60192	1	0.86538	1	0.040704	1	0.11945	1	0.89006	1	1	1	0.81738	1	0.51709	1	0.32867	1	0.391	1	0.13153	1	0.82409	1
PCDHAC2	17 (6%)	272	NA	NA	NA	NA	0.019994	1	0.41669	1	1	1	0.45257	1	0.59771	1	1	1	0.46514	1	0.30397	1	0.59642	1	0.18365	1
PTEN	13 (4%)	276	NA	NA	NA	NA	6.6492e-09	1.46e-06	1.6429e-10	3.71e-08	0.00050532	0.0995	0.0054257	1	2.0646e-08	4.52e-06	0.00037889	0.075	0.0023567	0.455	0.11703	1	1.8545e-10	4.17e-08	0.00069455	0.136
CREBZF	5 (2%)	284	NA	NA	NA	NA	0.063222	1	0.02251	1	0.085747	1	0.046983	1	0.69099	1	0.35234	1	0.62329	1	0.2025	1	0.66978	1	0.29058	1
EIF1AX	4 (1%)	285	NA	NA	NA	NA	0.16963	1	0.30268	1	0.3778	1	1	1	0.85458	1	0.81001	1	0.72148	1	0.15621	1	0.58451	1	0.24069	1
HTRA2	4 (1%)	285	NA	NA	NA	NA	0.28587	1	0.69825	1	0.41437	1	1	1	0.98856	1	0.63492	1	0.22655	1	1	1	0.96146	1	1	1
VAV3	8 (3%)	281	NA	NA	NA	NA	0.47536	1	0.61794	1	0.962	1	0.60544	1	0.030883	1	0.087439	1	0.3959	1	0.50184	1	0.79975	1	0.17724	1
TMEM216	3 (1%)	286	NA	NA	NA	NA	1	1	1	1	0.7941	1	0.64619	1	0.91694	1	0.54392	1	0.18471	1	0.59424	1	0.27305	1	0.6166	1
SPANXE	4 (1%)	285	NA	NA	NA	NA	0.36102	1	0.78841	1	0.34395	1	1	1	0.8079	1	0.63492	1	0.86292	1	1	1	0.0081776	1	1	1
TCF12	8 (3%)	281	NA	NA	NA	NA	0.41924	1	0.52617	1	0.19847	1	0.16795	1	0.59099	1	0.48638	1	0.09345	1	0.75012	1	0.65589	1	0.7895	1
SMARCA4	13 (4%)	276	NA	NA	NA	NA	0.11667	1	0.15233	1	0.31657	1	1	1	0.38147	1	0.51709	1	0.14667	1	0.27136	1	0.11484	1	0.32564	1
NF1	19 (7%)	270	NA	NA	NA	NA	0.014353	1	1.3961e-06	0.000299	0.031844	1	0.30501	1	0.0082858	1	1	1	0.76645	1	0.57321	1	0.0012941	0.252	0.0034902	0.663
BCOR	9 (3%)	280	1	1	1	1	0.46577	1	0.666	1	0.91592	1	0.77251	1	0.31024	1	0.47171	1	0.81081	1	0.24036	1	0.41912	1	0.25228	1