E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.042 0.172 -9999.0 0.0 -0.465 47.0 47.0 KLHL20 -0.028 0.058 -9999.0 0.0 -0.271 7.0 7.0 CYFIP2 0.008 0.055 -9999.0 0.0 -0.511 4.0 4.0 Rac1/GDP 0.003 0.116 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.043 0.173 -9999.0 0.0 -0.465 47.0 47.0 AP1M1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.013 0.026 -9999.0 0.0 -0.481 1.0 1.0 RAP1A 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.038 0.07 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.019 0.04 -9999.0 0.0 -0.182 8.0 8.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.101 0.164 -9999.0 0.0 -0.4 59.0 59.0 RAPGEF1 -0.02 0.152 -9999.0 0.0 -0.392 47.0 47.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.08 0.162 -9999.0 0.0 -0.485 47.0 47.0 CRK -0.031 0.163 -9999.0 0.0 -0.431 47.0 47.0 E-cadherin/gamma catenin/alpha catenin -0.09 0.152 -9999.0 0.0 -0.329 100.0 100.0 alphaE/beta7 Integrin -0.038 0.116 -9999.0 0.0 -0.386 36.0 36.0 IQGAP1 0.005 0.068 -9999.0 0.0 -0.521 6.0 6.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin -0.002 0.022 -9999.0 0.0 -0.29 2.0 2.0 DLG1 -0.042 0.172 -9999.0 0.0 -0.465 47.0 47.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.028 0.05 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.012 0.032 -9999.0 0.0 -0.603 1.0 1.0 ARF6/GTP/NME1/Tiam1 -0.0 0.018 -9999.0 0.0 -0.333 1.0 1.0 PI3K -0.035 0.064 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.109 0.182 -9999.0 0.0 -0.397 100.0 100.0 TIAM1 0.012 0.032 -9999.0 0.0 -0.603 1.0 1.0 E-cadherin(dimer)/Ca2+ -0.069 0.118 -9999.0 0.0 -0.306 47.0 47.0 AKT1 -0.02 0.036 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.13 0.246 -9999.0 0.0 -0.541 95.0 95.0 RhoA/GDP 0.003 0.116 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.021 0.043 -9999.0 0.0 -0.194 7.0 7.0 CDC42/GDP 0.003 0.116 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.037 0.113 -9999.0 0.0 -0.279 51.0 51.0 ITGB7 -0.041 0.167 -9999.0 0.0 -0.542 36.0 36.0 RAC1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.073 0.125 -9999.0 0.0 -0.325 47.0 47.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.071 0.121 -9999.0 0.0 -0.314 47.0 47.0 mol:GDP -0.008 0.131 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP/IQGAP1 -0.005 0.04 -9999.0 0.0 -0.312 6.0 6.0 JUP 0.001 0.086 -9999.0 0.0 -0.572 8.0 8.0 p120 catenin/RhoA/GDP -0.046 0.091 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1 -0.005 0.04 -9999.0 0.0 -0.312 6.0 6.0 PIP5K1C/AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.008 0.065 -9999.0 0.0 -0.212 22.0 22.0 NME1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.042 0.172 -9999.0 0.0 -0.465 47.0 47.0 regulation of cell-cell adhesion -0.034 0.062 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.009 0.021 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.045 0.08 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.099 0.163 -9999.0 0.0 -0.388 63.0 63.0 CCND1 0.008 0.08 -9999.0 0.0 -0.265 22.0 22.0 VAV2 -0.025 0.161 -9999.0 0.0 -0.421 47.0 47.0 RAP1/GDP -0.043 0.085 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.04 0.167 -9999.0 0.0 -0.449 47.0 47.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.061 0.173 -9999.0 0.0 -0.554 20.0 20.0 E-cadherin/beta catenin -0.073 0.138 -9999.0 0.0 -0.392 47.0 47.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.044 0.172 -9999.0 0.0 -0.465 47.0 47.0 PIK3CA 0.012 0.032 -9999.0 0.0 -0.603 1.0 1.0 Rac1/GTP -0.046 0.094 -9999.0 0.0 -0.462 7.0 7.0 E-cadherin/beta catenin/alpha catenin -0.083 0.142 -9999.0 0.0 -0.365 47.0 47.0 ITGAE 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.082 0.166 -9999.0 0.0 -0.496 47.0 47.0