Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.067 0.155 0.405 60.0 -9999.0 0.0 60.0 KIRREL -0.039 0.169 -9999.0 0.0 -0.601 30.0 30.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.067 0.155 -9999.0 0.0 -0.406 60.0 60.0 PLCG1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.049 0.113 -9999.0 0.0 -0.341 34.0 34.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.008 0.101 -9999.0 0.0 -0.294 32.0 32.0 FYN -0.028 0.114 -9999.0 0.0 -0.326 34.0 34.0 mol:Ca2+ -0.049 0.112 -9999.0 0.0 -0.338 34.0 34.0 mol:DAG -0.049 0.112 -9999.0 0.0 -0.34 34.0 34.0 NPHS2 -0.008 0.045 -9999.0 0.0 -0.538 2.0 2.0 mol:IP3 -0.049 0.112 -9999.0 0.0 -0.34 34.0 34.0 regulation of endocytosis -0.018 0.107 -9999.0 0.0 -0.299 34.0 34.0 Nephrin/NEPH1/podocin/Cholesterol -0.05 0.116 -9999.0 0.0 -0.303 57.0 57.0 establishment of cell polarity -0.067 0.155 -9999.0 0.0 -0.405 60.0 60.0 Nephrin/NEPH1/podocin/NCK1-2 -0.044 0.104 -9999.0 0.0 -0.416 8.0 8.0 Nephrin/NEPH1/beta Arrestin2 -0.017 0.109 -9999.0 0.0 -0.303 34.0 34.0 NPHS1 -0.038 0.147 -9999.0 0.0 -0.5 33.0 33.0 Nephrin/NEPH1/podocin -0.031 0.113 -9999.0 0.0 -0.327 34.0 34.0 TJP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.012 0.032 -9999.0 0.0 -0.603 1.0 1.0 NCK2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.049 0.113 -9999.0 0.0 -0.341 34.0 34.0 CD2AP 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 -0.049 0.113 -9999.0 0.0 -0.341 34.0 34.0 GRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.047 0.135 -9999.0 0.0 -0.33 46.0 46.0 cytoskeleton organization -0.008 0.118 -9999.0 0.0 -0.338 32.0 32.0 Nephrin/NEPH1 -0.047 0.111 -9999.0 0.0 -0.287 60.0 60.0 Nephrin/NEPH1/ZO-1 -0.052 0.121 -9999.0 0.0 -0.37 33.0 33.0