Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.095 0.29 -9999.0 0.0 -0.723 44.0 44.0 IHH -0.01 0.074 -9999.0 0.0 -0.47 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.084 0.151 -9999.0 0.0 -0.323 96.0 96.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.084 0.15 0.321 96.0 -9999.0 0.0 96.0 SMO/beta Arrestin2 -0.035 0.183 -9999.0 0.0 -0.704 14.0 14.0 SMO -0.044 0.193 -9999.0 0.0 -0.627 21.0 21.0 AKT1 0.004 0.087 -9999.0 0.0 -0.324 6.0 6.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.008 0.058 -9999.0 0.0 -0.542 4.0 4.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.043 0.19 -9999.0 0.0 -0.603 22.0 22.0 STIL -0.084 0.22 -9999.0 0.0 -0.549 47.0 47.0 DHH N/PTCH2 -0.056 0.141 -9999.0 0.0 -0.4 51.0 51.0 DHH N/PTCH1 -0.064 0.197 -9999.0 0.0 -0.56 27.0 27.0 PIK3CA 0.012 0.032 -9999.0 0.0 -0.603 1.0 1.0 DHH -0.042 0.168 -9999.0 0.0 -0.54 37.0 37.0 PTHLH -0.107 0.342 -9999.0 0.0 -0.932 43.0 43.0 determination of left/right symmetry -0.043 0.19 -9999.0 0.0 -0.603 22.0 22.0 PIK3R1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.105 0.336 -9999.0 0.0 -0.917 43.0 43.0 IHH N/Hhip -0.113 0.208 -9999.0 0.0 -0.439 102.0 102.0 DHH N/Hhip -0.144 0.205 -9999.0 0.0 -0.413 127.0 127.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.043 0.19 -9999.0 0.0 -0.603 22.0 22.0 pancreas development -0.138 0.252 -9999.0 0.0 -0.548 99.0 99.0 HHAT -0.007 0.11 -9999.0 0.0 -0.575 13.0 13.0 PI3K -0.001 0.023 -9999.0 0.0 -0.437 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.016 0.121 -9999.0 0.0 -0.492 22.0 22.0 somite specification -0.043 0.19 -9999.0 0.0 -0.603 22.0 22.0 SHH Np/Cholesterol/PTCH1 -0.087 0.22 -9999.0 0.0 -0.545 47.0 47.0 SHH Np/Cholesterol/PTCH2 -0.082 0.151 -9999.0 0.0 -0.324 93.0 93.0 SHH Np/Cholesterol/Megalin -0.167 0.204 -9999.0 0.0 -0.357 171.0 171.0 SHH -0.073 0.188 -9999.0 0.0 -0.418 80.0 80.0 catabolic process -0.044 0.186 -9999.0 0.0 -0.553 23.0 23.0 SMO/Vitamin D3 -0.079 0.225 -9999.0 0.0 -0.603 37.0 37.0 SHH Np/Cholesterol/Hhip -0.148 0.204 -9999.0 0.0 -0.361 151.0 151.0 LRP2 -0.173 0.267 -9999.0 0.0 -0.549 121.0 121.0 receptor-mediated endocytosis -0.169 0.225 -9999.0 0.0 -0.592 60.0 60.0 SHH Np/Cholesterol/BOC -0.072 0.141 -9999.0 0.0 -0.359 54.0 54.0 SHH Np/Cholesterol/CDO -0.086 0.155 -9999.0 0.0 -0.332 95.0 95.0 mesenchymal cell differentiation 0.147 0.202 0.358 151.0 -9999.0 0.0 151.0 mol:Vitamin D3 -0.085 0.221 -9999.0 0.0 -0.545 47.0 47.0 IHH N/PTCH2 -0.009 0.108 -9999.0 0.0 -0.444 19.0 19.0 CDON -0.018 0.133 -9999.0 0.0 -0.566 20.0 20.0 IHH N/PTCH1 -0.044 0.187 -9999.0 0.0 -0.557 23.0 23.0 Megalin/LRPAP1 -0.13 0.187 -9999.0 0.0 -0.392 121.0 121.0 PTCH2 -0.01 0.118 -9999.0 0.0 -0.578 15.0 15.0 SHH Np/Cholesterol -0.071 0.141 -9999.0 0.0 -0.326 80.0 80.0 PTCH1 -0.044 0.186 -9999.0 0.0 -0.556 23.0 23.0 HHIP -0.138 0.252 -9999.0 0.0 -0.548 99.0 99.0