Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.03 0.109 -9999.0 0.0 -0.259 54.0 54.0 epithelial cell differentiation -0.068 0.117 -9999.0 0.0 -0.303 47.0 47.0 CYFIP2 0.008 0.055 -9999.0 0.0 -0.511 4.0 4.0 ENAH 0.004 0.103 -9999.0 0.0 -0.366 1.0 1.0 EGFR -0.082 0.213 -9999.0 0.0 -0.55 62.0 62.0 EPHA2 -0.018 0.123 -9999.0 0.0 -0.491 23.0 23.0 MYO6 -0.033 0.126 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.003 0.031 -9999.0 0.0 -0.365 1.0 1.0 AQP5 -0.142 0.186 -9999.0 0.0 -0.52 54.0 54.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.032 0.125 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.036 0.13 -9999.0 0.0 -0.582 1.0 1.0 EGF -0.044 0.173 -9999.0 0.0 -0.557 37.0 37.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.085 0.141 -9999.0 0.0 -0.534 19.0 19.0 cortical microtubule organization -0.068 0.117 -9999.0 0.0 -0.303 47.0 47.0 GO:0000145 -0.031 0.119 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.069 0.118 -9999.0 0.0 -0.306 47.0 47.0 MLLT4 0.012 0.032 -9999.0 0.0 -0.603 1.0 1.0 ARF6/GDP -0.061 0.096 -9999.0 0.0 -0.406 6.0 6.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.018 0.068 -9999.0 0.0 -0.407 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.032 0.124 -9999.0 0.0 -0.382 1.0 1.0 PVRL2 0.011 0.041 -9999.0 0.0 -0.542 2.0 2.0 ZYX -0.037 0.128 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.016 0.061 -9999.0 0.0 -0.529 1.0 1.0 CDH1 -0.13 0.246 -9999.0 0.0 -0.541 95.0 95.0 EGFR/EGFR/EGF/EGF -0.127 0.164 -9999.0 0.0 -0.517 31.0 31.0 RhoA/GDP -0.063 0.107 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.028 0.123 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.007 0.109 -9999.0 0.0 -0.55 14.0 14.0 DIAPH1 0.001 0.04 -9999.0 0.0 -0.681 1.0 1.0 Wnt receptor signaling pathway 0.068 0.117 0.303 47.0 -9999.0 0.0 47.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.061 0.097 -9999.0 0.0 -0.406 6.0 6.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.029 0.126 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.011 0.037 -9999.0 0.0 -0.481 2.0 2.0 LPP -0.045 0.135 -9999.0 0.0 -0.431 4.0 4.0 Ephrin A1/EPHA2 -0.073 0.114 -9999.0 0.0 -0.465 5.0 5.0 SEC6/SEC8 -0.055 0.097 -9999.0 0.0 -0.476 3.0 3.0 MGAT3 -0.037 0.131 -9999.0 0.0 -0.594 1.0 1.0 HGF/MET -0.16 0.172 -9999.0 0.0 -0.489 49.0 49.0 HGF -0.069 0.191 -9999.0 0.0 -0.503 59.0 59.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.03 0.11 -9999.0 0.0 -0.26 54.0 54.0 actin cable formation 0.016 0.103 -9999.0 0.0 -0.33 2.0 2.0 KIAA1543 -0.063 0.168 -9999.0 0.0 -0.54 17.0 17.0 KIFC3 -0.034 0.129 -9999.0 0.0 -0.594 1.0 1.0 NCK1 0.012 0.032 -9999.0 0.0 -0.603 1.0 1.0 EXOC3 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.048 0.137 -9999.0 0.0 -0.46 4.0 4.0 NCK1/GIT1 -0.001 0.023 -9999.0 0.0 -0.437 1.0 1.0 mol:GDP -0.068 0.117 -9999.0 0.0 -0.303 47.0 47.0 EXOC4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.033 0.126 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.033 0.126 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.002 0.085 -9999.0 0.0 -0.603 7.0 7.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.006 0.114 -9999.0 0.0 -0.369 4.0 4.0 adherens junction assembly -0.043 0.165 -9999.0 0.0 -0.507 17.0 17.0 IGF-1R heterotetramer/IGF1 -0.069 0.117 -9999.0 0.0 -0.555 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.003 0.037 -9999.0 0.0 -0.403 3.0 3.0 MET -0.138 0.248 -9999.0 0.0 -0.535 101.0 101.0 PLEKHA7 -0.039 0.135 -9999.0 0.0 -0.569 3.0 3.0 mol:GTP -0.018 0.067 -9999.0 0.0 -0.405 3.0 3.0 establishment of epithelial cell apical/basal polarity -0.001 0.119 -9999.0 0.0 -0.451 3.0 3.0 cortical actin cytoskeleton stabilization -0.03 0.109 -9999.0 0.0 -0.259 54.0 54.0 regulation of cell-cell adhesion -0.028 0.123 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.03 0.11 -9999.0 0.0 -0.26 54.0 54.0