E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.031 0.145 -9999.0 0.0 -0.415 44.0 44.0 KLHL20 0.007 0.074 0.157 3.0 -0.22 5.0 8.0 CYFIP2 0.023 0.027 -9999.0 0.0 -0.429 1.0 1.0 Rac1/GDP -0.007 0.099 0.252 3.0 -0.26 38.0 41.0 ENAH -0.037 0.152 -9999.0 0.0 -0.415 49.0 49.0 AP1M1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.021 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.006 0.068 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.016 0.037 -9999.0 0.0 -0.149 6.0 6.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.015 0.126 -9999.0 0.0 -0.271 55.0 55.0 RAPGEF1 -0.022 0.142 0.236 6.0 -0.373 44.0 50.0 CTNND1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.032 0.157 -9999.0 0.0 -0.421 50.0 50.0 CRK -0.035 0.141 0.228 1.0 -0.395 46.0 47.0 E-cadherin/gamma catenin/alpha catenin 0.012 0.11 -9999.0 0.0 -0.264 48.0 48.0 alphaE/beta7 Integrin 0.015 0.078 -9999.0 0.0 -0.305 18.0 18.0 IQGAP1 0.021 0.037 -9999.0 0.0 -0.429 2.0 2.0 NCKAP1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.037 0.026 -9999.0 0.0 -0.233 1.0 1.0 DLG1 -0.035 0.15 -9999.0 0.0 -0.41 49.0 49.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.016 0.047 -9999.0 0.0 -0.145 2.0 2.0 MLLT4 0.024 0.024 -9999.0 0.0 -0.429 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.048 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.017 0.06 -9999.0 0.0 -0.186 1.0 1.0 ARF6 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.023 0.12 -9999.0 0.0 -0.312 48.0 48.0 TIAM1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.026 0.092 -9999.0 0.0 -0.22 42.0 42.0 AKT1 -0.004 0.045 0.14 1.0 -9999.0 0.0 1.0 PIK3R1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.051 0.152 -9999.0 0.0 -0.271 94.0 94.0 RhoA/GDP 0.001 0.107 0.252 6.0 -0.259 41.0 47.0 actin cytoskeleton organization 0.012 0.063 0.166 14.0 -0.16 5.0 19.0 CDC42/GDP -0.004 0.103 0.244 3.0 -0.253 41.0 44.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.013 0.081 -9999.0 0.0 -0.223 45.0 45.0 ITGB7 -0.004 0.102 -9999.0 0.0 -0.274 36.0 36.0 RAC1 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.029 0.098 -9999.0 0.0 -0.235 42.0 42.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.013 0.089 -9999.0 0.0 -0.218 46.0 46.0 mol:GDP -0.015 0.117 0.255 7.0 -0.297 41.0 48.0 CDC42/GTP/IQGAP1 0.027 0.025 -9999.0 0.0 -0.232 2.0 2.0 JUP 0.02 0.048 -9999.0 0.0 -0.429 4.0 4.0 p120 catenin/RhoA/GDP 0.004 0.108 0.259 4.0 -0.266 40.0 44.0 RAC1/GTP/IQGAP1 0.028 0.026 -9999.0 0.0 -0.256 2.0 2.0 PIP5K1C/AP1M1 0.037 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.011 0.054 0.141 15.0 -0.175 11.0 26.0 NME1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.036 0.152 -9999.0 0.0 -0.414 49.0 49.0 regulation of cell-cell adhesion -0.01 0.056 -9999.0 0.0 -0.167 1.0 1.0 WASF2 0.008 0.029 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.0 0.085 0.235 2.0 -0.206 1.0 3.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.024 0.13 -9999.0 0.0 -0.264 57.0 57.0 CCND1 0.01 0.063 0.161 12.0 -0.217 11.0 23.0 VAV2 -0.016 0.161 -9999.0 0.0 -0.418 40.0 40.0 RAP1/GDP 0.004 0.094 0.251 2.0 -0.228 21.0 23.0 adherens junction assembly -0.035 0.147 -9999.0 0.0 -0.401 49.0 49.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.011 0.122 -9999.0 0.0 -0.255 57.0 57.0 E-cadherin/beta catenin -0.032 0.109 -9999.0 0.0 -0.322 44.0 44.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.037 0.149 -9999.0 0.0 -0.408 49.0 49.0 PIK3CA 0.024 0.024 -9999.0 0.0 -0.429 1.0 1.0 Rac1/GTP -0.021 0.089 -9999.0 0.0 -0.337 6.0 6.0 E-cadherin/beta catenin/alpha catenin 0.014 0.105 -9999.0 0.0 -0.258 46.0 46.0 ITGAE 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.033 0.161 -9999.0 0.0 -0.43 50.0 50.0