Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.041 0.187 -9999.0 0.0 -0.573 37.0 37.0 IHH 0.013 0.053 -9999.0 0.0 -0.181 3.0 3.0 SHH Np/Cholesterol/GAS1 -0.008 0.084 0.158 11.0 -0.235 37.0 48.0 LRPAP1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.008 0.083 0.234 37.0 -0.157 11.0 48.0 SMO/beta Arrestin2 -0.004 0.115 -9999.0 0.0 -0.357 24.0 24.0 SMO -0.017 0.113 -9999.0 0.0 -0.374 24.0 24.0 AKT1 0.001 0.1 -9999.0 0.0 -0.503 9.0 9.0 ARRB2 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.022 0.035 -9999.0 0.0 -0.274 4.0 4.0 ADRBK1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.017 0.111 -9999.0 0.0 -0.369 24.0 24.0 STIL -0.008 0.131 0.187 38.0 -0.275 39.0 77.0 DHH N/PTCH2 0.006 0.082 -9999.0 0.0 -0.305 21.0 21.0 DHH N/PTCH1 -0.016 0.122 -9999.0 0.0 -0.29 52.0 52.0 PIK3CA 0.024 0.024 -9999.0 0.0 -0.429 1.0 1.0 DHH -0.004 0.1 -9999.0 0.0 -0.27 35.0 35.0 PTHLH -0.057 0.249 -9999.0 0.0 -0.761 37.0 37.0 determination of left/right symmetry -0.017 0.111 -9999.0 0.0 -0.369 24.0 24.0 PIK3R1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.056 0.246 -9999.0 0.0 -0.752 37.0 37.0 IHH N/Hhip -0.036 0.134 -9999.0 0.0 -0.348 50.0 50.0 DHH N/Hhip -0.045 0.135 -9999.0 0.0 -0.308 68.0 68.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.017 0.111 -9999.0 0.0 -0.369 24.0 24.0 pancreas development -0.055 0.156 -9999.0 0.0 -0.428 50.0 50.0 HHAT 0.012 0.075 -9999.0 0.0 -0.429 10.0 10.0 PI3K 0.037 0.019 -9999.0 0.0 -0.305 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.016 0.046 -9999.0 0.0 -0.429 2.0 2.0 somite specification -0.017 0.111 -9999.0 0.0 -0.369 24.0 24.0 SHH Np/Cholesterol/PTCH1 -0.033 0.112 -9999.0 0.0 -0.27 52.0 52.0 SHH Np/Cholesterol/PTCH2 -0.017 0.083 -9999.0 0.0 -0.24 41.0 41.0 SHH Np/Cholesterol/Megalin -0.052 0.12 0.156 4.0 -0.271 73.0 77.0 SHH -0.027 0.096 -9999.0 0.0 -0.308 37.0 37.0 catabolic process -0.016 0.116 -9999.0 0.0 -0.343 36.0 36.0 SMO/Vitamin D3 -0.029 0.116 0.227 1.0 -0.334 25.0 26.0 SHH Np/Cholesterol/Hhip -0.046 0.118 0.162 3.0 -0.273 67.0 70.0 LRP2 -0.077 0.172 -9999.0 0.0 -0.429 65.0 65.0 receptor-mediated endocytosis -0.059 0.143 -9999.0 0.0 -0.416 32.0 32.0 SHH Np/Cholesterol/BOC -0.012 0.08 -9999.0 0.0 -0.236 39.0 39.0 SHH Np/Cholesterol/CDO -0.017 0.086 -9999.0 0.0 -0.246 41.0 41.0 mesenchymal cell differentiation 0.046 0.117 0.272 67.0 -0.16 3.0 70.0 mol:Vitamin D3 0.002 0.144 0.202 42.0 -0.28 46.0 88.0 IHH N/PTCH2 0.022 0.056 -9999.0 0.0 -0.371 5.0 5.0 CDON 0.005 0.089 -9999.0 0.0 -0.429 14.0 14.0 IHH N/PTCH1 -0.008 0.12 -9999.0 0.0 -0.345 36.0 36.0 Megalin/LRPAP1 -0.04 0.129 -9999.0 0.0 -0.304 65.0 65.0 PTCH2 0.014 0.054 -9999.0 0.0 -0.429 5.0 5.0 SHH Np/Cholesterol -0.017 0.075 0.205 1.0 -0.233 37.0 38.0 PTCH1 -0.016 0.116 -9999.0 0.0 -0.344 36.0 36.0 HHIP -0.055 0.157 -9999.0 0.0 -0.429 50.0 50.0