Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.012 0.084 -9999.0 0.0 -0.22 48.0 48.0 epithelial cell differentiation 0.022 0.089 -9999.0 0.0 -0.218 42.0 42.0 CYFIP2 0.023 0.027 -9999.0 0.0 -0.429 1.0 1.0 ENAH -0.026 0.062 0.271 3.0 -9999.0 0.0 3.0 EGFR -0.013 0.119 -9999.0 0.0 -0.429 27.0 27.0 EPHA2 0.011 0.047 -9999.0 0.0 -0.146 23.0 23.0 MYO6 -0.016 0.081 0.177 14.0 -0.21 42.0 56.0 CTNNB1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.047 0.023 -9999.0 0.0 -0.234 1.0 1.0 AQP5 -0.068 0.167 -9999.0 0.0 -0.444 50.0 50.0 CTNND1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.016 0.078 0.176 13.0 -0.208 40.0 53.0 regulation of calcium-dependent cell-cell adhesion -0.018 0.083 0.176 14.0 -0.212 44.0 58.0 EGF -0.006 0.106 -9999.0 0.0 -0.429 20.0 20.0 NCKAP1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.026 0.114 -9999.0 0.0 -0.448 17.0 17.0 cortical microtubule organization 0.022 0.089 -9999.0 0.0 -0.218 42.0 42.0 GO:0000145 -0.028 0.07 0.164 13.0 -0.199 40.0 53.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.026 0.092 -9999.0 0.0 -0.22 42.0 42.0 MLLT4 0.024 0.024 -9999.0 0.0 -0.429 1.0 1.0 ARF6/GDP -0.04 0.057 -9999.0 0.0 -0.199 25.0 25.0 ARF6 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.053 0.04 -9999.0 0.0 -0.251 3.0 3.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.029 0.086 -9999.0 0.0 -0.339 13.0 13.0 PVRL2 0.02 0.027 -9999.0 0.0 -0.274 2.0 2.0 ZYX -0.014 0.07 0.177 8.0 -0.211 33.0 41.0 ARF6/GTP 0.057 0.041 -9999.0 0.0 -0.235 3.0 3.0 CDH1 -0.051 0.152 -9999.0 0.0 -0.271 94.0 94.0 EGFR/EGFR/EGF/EGF -0.02 0.115 -9999.0 0.0 -0.233 74.0 74.0 RhoA/GDP 0.024 0.086 -9999.0 0.0 -0.208 42.0 42.0 actin cytoskeleton organization -0.031 0.076 0.165 14.0 -0.207 45.0 59.0 IGF-1R heterotetramer 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.014 0.069 -9999.0 0.0 -0.296 14.0 14.0 DIAPH1 0.028 0.106 -9999.0 0.0 -0.555 5.0 5.0 Wnt receptor signaling pathway -0.022 0.089 0.218 42.0 -9999.0 0.0 42.0 RHOA 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.04 0.057 -9999.0 0.0 -0.2 25.0 25.0 CTNNA1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.032 0.078 0.167 14.0 -0.212 45.0 59.0 EFNA1 0.025 0.012 -9999.0 0.0 -0.119 2.0 2.0 LPP -0.038 0.076 0.17 12.0 -0.206 47.0 59.0 Ephrin A1/EPHA2 0.012 0.081 -9999.0 0.0 -0.201 41.0 41.0 SEC6/SEC8 -0.017 0.062 -9999.0 0.0 -0.212 20.0 20.0 MGAT3 -0.018 0.084 0.177 14.0 -0.215 44.0 58.0 HGF/MET -0.022 0.114 -9999.0 0.0 -0.239 67.0 67.0 HGF -0.002 0.077 -9999.0 0.0 -0.178 42.0 42.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.012 0.085 -9999.0 0.0 -0.221 48.0 48.0 actin cable formation -0.003 0.099 0.32 12.0 -0.24 9.0 21.0 KIAA1543 -0.033 0.074 0.166 9.0 -0.212 42.0 51.0 KIFC3 -0.017 0.083 0.177 14.0 -0.216 42.0 56.0 NCK1 0.024 0.024 -9999.0 0.0 -0.429 1.0 1.0 EXOC3 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.021 0.081 0.177 12.0 -0.212 43.0 55.0 NCK1/GIT1 0.037 0.019 -9999.0 0.0 -0.305 1.0 1.0 mol:GDP 0.022 0.089 -9999.0 0.0 -0.218 42.0 42.0 EXOC4 0.02 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.016 0.081 0.177 14.0 -0.211 42.0 56.0 PIP5K1C -0.016 0.079 0.177 13.0 -0.211 40.0 53.0 LIMA1 0.018 0.058 -9999.0 0.0 -0.429 6.0 6.0 ABI1 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.023 0.085 0.367 6.0 -9999.0 0.0 6.0 adherens junction assembly -0.01 0.087 0.279 6.0 -0.411 3.0 9.0 IGF-1R heterotetramer/IGF1 0.013 0.091 -9999.0 0.0 -0.216 47.0 47.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.029 0.03 -9999.0 0.0 -0.305 2.0 2.0 MET -0.042 0.135 -9999.0 0.0 -0.429 35.0 35.0 PLEKHA7 -0.02 0.083 0.179 10.0 -0.221 42.0 52.0 mol:GTP 0.051 0.039 -9999.0 0.0 -0.25 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.017 0.12 0.329 20.0 -0.367 1.0 21.0 cortical actin cytoskeleton stabilization -0.012 0.084 -9999.0 0.0 -0.22 48.0 48.0 regulation of cell-cell adhesion -0.031 0.076 0.165 14.0 -0.207 45.0 59.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.012 0.085 -9999.0 0.0 -0.221 48.0 48.0