Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.075 0.145 -9999.0 0.0 -0.255 9.0 9.0 epithelial cell differentiation -0.058 0.143 -9999.0 0.0 -0.241 9.0 9.0 CYFIP2 0.027 0.032 -9999.0 0.0 -0.135 1.0 1.0 ENAH -0.056 0.093 -9999.0 0.0 -0.403 1.0 1.0 EGFR -0.009 0.123 -9999.0 0.0 -0.428 2.0 2.0 EPHA2 0.023 0.033 -9999.0 0.0 -0.135 1.0 1.0 MYO6 -0.078 0.149 -9999.0 0.0 -0.253 9.0 9.0 CTNNB1 -0.001 0.121 -9999.0 0.0 -0.428 2.0 2.0 ABI1/Sra1/Nap1 0.054 0.035 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.052 0.118 -9999.0 0.0 -0.392 1.0 1.0 CTNND1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.061 0.113 -9999.0 0.0 -0.21 9.0 9.0 regulation of calcium-dependent cell-cell adhesion -0.07 0.124 -9999.0 0.0 -0.226 9.0 9.0 EGF 0.019 0.044 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.061 0.138 -9999.0 0.0 -0.427 2.0 2.0 cortical microtubule organization -0.058 0.143 -9999.0 0.0 -0.241 9.0 9.0 GO:0000145 -0.066 0.103 -9999.0 0.0 -0.201 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.055 0.147 -9999.0 0.0 -0.243 9.0 9.0 MLLT4 0.014 0.087 -9999.0 0.0 -0.428 1.0 1.0 ARF6/GDP -0.076 0.103 -9999.0 0.0 -0.306 2.0 2.0 ARF6 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.06 0.049 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.068 0.106 -9999.0 0.0 -0.299 2.0 2.0 PVRL2 0.011 0.087 -9999.0 0.0 -0.428 1.0 1.0 ZYX -0.065 0.129 -9999.0 0.0 -0.232 9.0 9.0 ARF6/GTP 0.076 0.037 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.14 0.198 -9999.0 0.0 -0.302 14.0 14.0 EGFR/EGFR/EGF/EGF -0.08 0.133 -9999.0 0.0 -0.228 11.0 11.0 RhoA/GDP -0.058 0.158 -9999.0 0.0 -0.249 9.0 9.0 actin cytoskeleton organization -0.078 0.142 0.173 1.0 -0.246 9.0 10.0 IGF-1R heterotetramer 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.017 0.087 -9999.0 0.0 -0.428 1.0 1.0 DIAPH1 0.02 0.153 -9999.0 0.0 -0.561 1.0 1.0 Wnt receptor signaling pathway 0.058 0.143 0.241 9.0 -9999.0 0.0 9.0 RHOA 0.014 0.087 -9999.0 0.0 -0.428 1.0 1.0 RhoA/GTP -0.082 0.124 -9999.0 0.0 -0.382 2.0 2.0 CTNNA1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.08 0.145 -9999.0 0.0 -0.252 9.0 9.0 EFNA1 0.028 0.032 -9999.0 0.0 -0.135 1.0 1.0 LPP -0.066 0.106 -9999.0 0.0 -0.225 2.0 2.0 Ephrin A1/EPHA2 -0.062 0.132 -9999.0 0.0 -0.227 9.0 9.0 SEC6/SEC8 -0.081 0.133 -9999.0 0.0 -0.335 3.0 3.0 MGAT3 -0.071 0.126 -9999.0 0.0 -0.23 9.0 9.0 HGF/MET -0.059 0.133 -9999.0 0.0 -0.23 9.0 9.0 HGF 0.012 0.053 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.076 0.146 -9999.0 0.0 -0.257 9.0 9.0 actin cable formation -0.039 0.084 -9999.0 0.0 -0.274 1.0 1.0 KIAA1543 -0.08 0.106 -9999.0 0.0 -0.219 9.0 9.0 KIFC3 -0.07 0.127 -9999.0 0.0 -0.232 9.0 9.0 NCK1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.073 0.126 -9999.0 0.0 -0.232 9.0 9.0 NCK1/GIT1 0.049 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.058 0.143 -9999.0 0.0 -0.241 9.0 9.0 EXOC4 0.029 0.012 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.07 0.127 -9999.0 0.0 -0.232 9.0 9.0 PIP5K1C -0.062 0.115 -9999.0 0.0 -0.213 9.0 9.0 LIMA1 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.03 0.011 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.07 0.112 -9999.0 0.0 -0.484 1.0 1.0 adherens junction assembly -0.046 0.12 0.293 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer/IGF1 -0.061 0.153 -9999.0 0.0 -0.246 9.0 9.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.011 0.092 -9999.0 0.0 -0.303 2.0 2.0 MET 0.023 0.033 -9999.0 0.0 -0.135 1.0 1.0 PLEKHA7 -0.077 0.117 -9999.0 0.0 -0.23 9.0 9.0 mol:GTP 0.058 0.047 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.042 0.166 0.286 1.0 -0.522 1.0 2.0 cortical actin cytoskeleton stabilization -0.075 0.145 -9999.0 0.0 -0.255 9.0 9.0 regulation of cell-cell adhesion -0.078 0.142 0.173 1.0 -0.246 9.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.076 0.146 -9999.0 0.0 -0.257 9.0 9.0