Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	6.0	310.0	51.0	-0.771	0.034	1000.0	-1000.0	-0.063	-1000.0
E-cadherin signaling events	6.0	34.0	5.0	-0.14	0.034	1000.0	-1000.0	0.016	-1000.0
Ephrin A  reverse signaling	5.0	38.0	7.0	-0.11	-0.0	1000.0	-1000.0	-0.0	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	301.0	68.0	-0.505	0.323	1000.0	-1000.0	-0.052	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	314.0	74.0	-0.14	0.076	1000.0	-1000.0	-0.053	-1000.0
TCGA08_retinoblastoma	4.0	36.0	8.0	-0.053	0.085	1000.0	-1000.0	-0.003	-1000.0
IL23-mediated signaling events	4.0	292.0	60.0	-0.66	0.036	1000.0	-1000.0	-0.074	-1000.0
IL12-mediated signaling events	3.0	310.0	87.0	-0.408	0.06	1000.0	-1000.0	-0.045	-1000.0
PLK2 and PLK4 events	3.0	11.0	3.0	-0.04	-1000.0	1000.0	-1000.0	0.002	-1000.0
Signaling events mediated by the Hedgehog family	3.0	180.0	52.0	-0.137	0.067	1000.0	-1000.0	-0.028	-1000.0
Thromboxane A2 receptor signaling	3.0	418.0	105.0	-0.241	0.046	1000.0	-1000.0	-0.039	-1000.0
Ephrin B reverse signaling	3.0	160.0	48.0	-0.11	0.051	1000.0	-1000.0	-0.021	-1000.0
Endothelins	3.0	361.0	96.0	-0.329	0.047	1000.0	-1000.0	-0.04	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	269.0	76.0	-0.155	0.052	1000.0	-1000.0	-0.052	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	291.0	136.0	-0.412	0.094	1000.0	-1000.0	-0.029	-1000.0
Visual signal transduction: Cones	2.0	83.0	38.0	-0.069	0.039	1000.0	-1000.0	-0.0	-1000.0
Osteopontin-mediated events	2.0	77.0	38.0	-0.11	0.034	1000.0	-1000.0	-0.026	-1000.0
Noncanonical Wnt signaling pathway	2.0	52.0	26.0	-0.031	0.033	1000.0	-1000.0	-0.027	-1000.0
HIF-1-alpha transcription factor network	2.0	196.0	76.0	-0.208	0.059	1000.0	-1000.0	-0.028	-1000.0
Arf6 signaling events	2.0	126.0	62.0	-0.059	0.067	1000.0	-1000.0	-0.007	-1000.0
PLK1 signaling events	2.0	208.0	85.0	-0.131	0.049	1000.0	-1000.0	-0.027	-1000.0
PDGFR-alpha signaling pathway	2.0	106.0	44.0	-0.246	0.042	1000.0	-1000.0	-0.034	-1000.0
Signaling events regulated by Ret tyrosine kinase	2.0	182.0	82.0	-0.062	0.05	1000.0	-1000.0	-0.04	-1000.0
Syndecan-3-mediated signaling events	2.0	80.0	35.0	-0.093	0.081	1000.0	-1000.0	-0.013	-1000.0
Calcium signaling in the CD4+ TCR pathway	2.0	63.0	31.0	-0.111	0.044	1000.0	-1000.0	-0.038	-1000.0
Nongenotropic Androgen signaling	2.0	128.0	52.0	-0.205	0.1	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	327.0	125.0	-0.096	0.08	1000.0	-1000.0	-0.038	-1000.0
Wnt signaling	2.0	14.0	7.0	-0.026	0.033	1000.0	-1000.0	-0.003	-1000.0
IL6-mediated signaling events	2.0	156.0	75.0	-0.148	0.052	1000.0	-1000.0	-0.036	-1000.0
Syndecan-4-mediated signaling events	2.0	157.0	67.0	-0.106	0.045	1000.0	-1000.0	-0.032	-1000.0
E-cadherin signaling in keratinocytes	2.0	109.0	43.0	-0.14	0.039	1000.0	-1000.0	-0.02	-1000.0
Aurora B signaling	2.0	165.0	67.0	-0.178	0.049	1000.0	-1000.0	-0.034	-1000.0
Caspase cascade in apoptosis	1.0	123.0	74.0	-0.066	0.039	1000.0	-1000.0	-0.035	-1000.0
Coregulation of Androgen receptor activity	1.0	88.0	76.0	-0.087	0.059	1000.0	-1000.0	-0.038	-1000.0
ErbB4 signaling events	1.0	77.0	69.0	-0.121	0.051	1000.0	-1000.0	-0.025	-1000.0
Syndecan-1-mediated signaling events	1.0	60.0	34.0	-0.188	0.034	1000.0	-1000.0	-0.021	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	28.0	28.0	-0.041	0.045	1000.0	-1000.0	-0.008	-1000.0
Syndecan-2-mediated signaling events	1.0	87.0	69.0	-0.068	0.048	1000.0	-1000.0	-0.024	-1000.0
Cellular roles of Anthrax toxin	1.0	58.0	39.0	-0.179	0.033	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by PTP1B	1.0	76.0	76.0	-0.035	0.054	1000.0	-1000.0	-0.042	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	76.0	61.0	-0.181	0.081	1000.0	-1000.0	-0.04	-1000.0
Aurora A signaling	1.0	66.0	60.0	-0.094	0.086	1000.0	-1000.0	-0.011	-1000.0
p75(NTR)-mediated signaling	1.0	159.0	125.0	-0.188	0.081	1000.0	-1000.0	-0.035	-1000.0
IL4-mediated signaling events	1.0	166.0	91.0	-0.505	0.263	1000.0	-1000.0	-0.077	-1000.0
BMP receptor signaling	1.0	134.0	81.0	-0.068	0.066	1000.0	-1000.0	-0.027	-1000.0
Fc-epsilon receptor I signaling in mast cells	1.0	139.0	97.0	-0.111	0.055	1000.0	-1000.0	-0.036	-1000.0
amb2 Integrin signaling	1.0	107.0	82.0	-0.078	0.048	1000.0	-1000.0	-0.019	-1000.0
Nectin adhesion pathway	1.0	77.0	63.0	-0.14	0.064	1000.0	-1000.0	-0.056	-1000.0
Glucocorticoid receptor regulatory network	1.0	139.0	114.0	-0.265	0.075	1000.0	-1000.0	-0.044	-1000.0
Ceramide signaling pathway	1.0	108.0	76.0	-0.067	0.053	1000.0	-1000.0	-0.029	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	50.0	37.0	-0.097	0.057	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by HDAC Class III	1.0	50.0	40.0	-0.136	0.092	1000.0	-1000.0	-0.032	-1000.0
TRAIL signaling pathway	1.0	55.0	48.0	-0.006	0.059	1000.0	-1000.0	-0.034	-1000.0
IL1-mediated signaling events	1.0	120.0	62.0	-0.108	0.057	1000.0	-1000.0	-0.022	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	59.0	52.0	-0.251	0.098	1000.0	-1000.0	-0.033	-1000.0
S1P1 pathway	1.0	57.0	36.0	-0.096	0.034	1000.0	-1000.0	-0.02	-1000.0
TCGA08_p53	1.0	9.0	7.0	-0.044	0.033	1000.0	-1000.0	-0.01	-1000.0
Signaling mediated by p38-alpha and p38-beta	1.0	78.0	44.0	-0.064	0.033	1000.0	-1000.0	-0.013	-1000.0
Integrins in angiogenesis	1.0	127.0	84.0	-0.084	0.08	1000.0	-1000.0	-0.031	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	45.0	45.0	-0.031	0.058	1000.0	-1000.0	-0.043	-1000.0
Canonical Wnt signaling pathway	1.0	56.0	51.0	-0.181	0.081	1000.0	-1000.0	-0.03	-1000.0
EPHB forward signaling	1.0	128.0	85.0	-0.061	0.076	1000.0	-1000.0	-0.043	-1000.0
Effects of Botulinum toxin	1.0	34.0	26.0	-0.158	0.054	1000.0	-1000.0	-0.002	-1000.0
LPA receptor mediated events	1.0	106.0	102.0	-0.159	0.049	1000.0	-1000.0	-0.108	-1000.0
BCR signaling pathway	1.0	192.0	99.0	-0.104	0.051	1000.0	-1000.0	-0.047	-1000.0
EGFR-dependent Endothelin signaling events	1.0	28.0	21.0	-0.031	0.058	1000.0	-1000.0	-0.03	-1000.0
Angiopoietin receptor Tie2-mediated signaling	1.0	124.0	88.0	-0.144	0.045	1000.0	-1000.0	-0.062	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	1.0	135.0	120.0	-0.159	0.098	1000.0	-1000.0	-0.038	-1000.0
Visual signal transduction: Rods	1.0	94.0	52.0	-0.069	0.044	1000.0	-1000.0	-0.006	-1000.0
Signaling events mediated by PRL	1.0	62.0	34.0	-0.156	0.045	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	1.0	121.0	78.0	-0.077	0.047	1000.0	-1000.0	-0.042	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	24.0	17.0	-0.045	0.036	1000.0	-1000.0	-0.018	-1000.0
LPA4-mediated signaling events	0.0	7.0	12.0	-0.051	0.01	1000.0	-1000.0	-0.013	-1000.0
ErbB2/ErbB3 signaling events	0.0	56.0	65.0	-0.072	0.048	1000.0	-1000.0	-0.059	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	4.0	23.0	-0.002	0.061	1000.0	-1000.0	-0.023	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	0.0	1.0	34.0	-0.043	0.082	1000.0	-1000.0	-0.019	-1000.0
Canonical NF-kappaB pathway	0.0	16.0	39.0	-0.031	0.068	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by HDAC Class II	0.0	26.0	75.0	-0.047	0.085	1000.0	-1000.0	-0.014	-1000.0
BARD1 signaling events	0.0	55.0	57.0	-0.059	0.066	1000.0	-1000.0	-0.033	-1000.0
Circadian rhythm pathway	0.0	13.0	22.0	-0.078	0.057	1000.0	-1000.0	-0.036	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	0.0	32.0	54.0	-0.024	0.084	1000.0	-1000.0	-0.02	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	6.0	17.0	0.0	0.069	1000.0	-1000.0	-0.024	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	4.0	5.0	0.009	0.033	1000.0	-1000.0	0.019	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	0.0	65.0	85.0	-0.243	0.082	1000.0	-1000.0	-0.045	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	46.0	65.0	-0.039	0.071	1000.0	-1000.0	-0.035	-1000.0
Arf6 downstream pathway	0.0	8.0	43.0	-0.05	0.069	1000.0	-1000.0	-0.02	-1000.0
Aurora C signaling	0.0	3.0	7.0	-0.0	0.042	1000.0	-1000.0	-0.006	-1000.0
FOXA2 and FOXA3 transcription factor networks	0.0	16.0	46.0	-0.03	0.065	1000.0	-1000.0	-0.08	-1000.0
Glypican 1 network	0.0	37.0	48.0	-0.042	0.061	1000.0	-1000.0	-0.015	-1000.0
EPO signaling pathway	0.0	38.0	55.0	-0.002	0.089	1000.0	-1000.0	-0.015	-1000.0
Insulin-mediated glucose transport	0.0	8.0	32.0	-0.0	0.069	1000.0	-1000.0	-0.019	-1000.0
mTOR signaling pathway	0.0	19.0	53.0	-0.028	0.061	1000.0	-1000.0	-0.029	-1000.0
IFN-gamma pathway	0.0	38.0	68.0	-0.043	0.057	1000.0	-1000.0	-0.047	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	15.0	68.0	-0.052	0.068	1000.0	-1000.0	-0.025	-1000.0
Reelin signaling pathway	0.0	23.0	56.0	-0.052	0.085	1000.0	-1000.0	-0.016	-1000.0
S1P5 pathway	0.0	4.0	17.0	-0.007	0.034	1000.0	-1000.0	-0.005	-1000.0
ceramide signaling pathway	0.0	31.0	49.0	-0.031	0.049	1000.0	-1000.0	-0.037	-1000.0
HIF-2-alpha transcription factor network	0.0	26.0	43.0	-0.117	0.119	1000.0	-1000.0	-0.048	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	45.0	83.0	-0.025	0.067	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by HDAC Class I	0.0	38.0	104.0	-0.063	0.071	1000.0	-1000.0	-0.028	-1000.0
FoxO family signaling	0.0	27.0	64.0	-0.082	0.065	1000.0	-1000.0	-0.04	-1000.0
FAS signaling pathway (CD95)	0.0	31.0	47.0	-0.044	0.047	1000.0	-1000.0	-0.024	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	13.0	15.0	-0.059	0.033	1000.0	-1000.0	-0.013	-1000.0
Retinoic acid receptors-mediated signaling	0.0	22.0	58.0	-0.042	0.067	1000.0	-1000.0	-0.035	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	30.0	36.0	-0.097	0.064	1000.0	-1000.0	-0.031	-1000.0
Atypical NF-kappaB pathway	0.0	15.0	31.0	-0.013	0.047	1000.0	-1000.0	-0.01	-1000.0
IL2 signaling events mediated by PI3K	0.0	20.0	58.0	-0.017	0.058	1000.0	-1000.0	-0.034	-1000.0
TCR signaling in naïve CD8+ T cells	0.0	83.0	93.0	-0.144	0.169	1000.0	-1000.0	-0.041	-1000.0
Regulation of p38-alpha and p38-beta	0.0	43.0	54.0	-0.041	0.075	1000.0	-1000.0	-0.04	-1000.0
Glypican 2 network	0.0	2.0	4.0	0.0	0.015	1000.0	-1000.0	-0.0	-1000.0
IL27-mediated signaling events	0.0	37.0	51.0	-0.103	0.068	1000.0	-1000.0	-0.043	-1000.0
TCGA08_rtk_signaling	0.0	25.0	26.0	-0.052	0.071	1000.0	-1000.0	-0.012	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.0	0.081	1000.0	-1000.0	-0.023	-1000.0
IL2 signaling events mediated by STAT5	0.0	19.0	22.0	-0.08	0.044	1000.0	-1000.0	-0.024	-1000.0
Class I PI3K signaling events	0.0	70.0	73.0	-0.06	0.067	1000.0	-1000.0	-0.024	-1000.0
Arf6 trafficking events	0.0	18.0	71.0	-0.053	0.066	1000.0	-1000.0	-0.022	-1000.0
Regulation of Telomerase	0.0	80.0	102.0	-0.128	0.087	1000.0	-1000.0	-0.036	-1000.0
IGF1 pathway	0.0	17.0	57.0	-0.03	0.088	1000.0	-1000.0	-0.024	-1000.0
Insulin Pathway	0.0	37.0	74.0	-0.044	0.081	1000.0	-1000.0	-0.025	-1000.0
Plasma membrane estrogen receptor signaling	0.0	47.0	86.0	-0.043	0.049	1000.0	-1000.0	-0.043	-1000.0
VEGFR1 specific signals	0.0	6.0	56.0	-0.019	0.073	1000.0	-1000.0	-0.027	-1000.0
S1P3 pathway	0.0	18.0	42.0	-0.041	0.05	1000.0	-1000.0	-0.026	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	14.0	33.0	-0.055	0.087	1000.0	-1000.0	-0.032	-1000.0
Rapid glucocorticoid signaling	0.0	19.0	20.0	-0.097	0.028	1000.0	-1000.0	-0.003	-1000.0
PDGFR-beta signaling pathway	0.0	71.0	97.0	-0.04	0.094	1000.0	-1000.0	-0.028	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.031	0.032	1000.0	-1000.0	-0.018	-1000.0
S1P4 pathway	0.0	4.0	25.0	-0.0	0.045	1000.0	-1000.0	-0.012	-1000.0
p38 MAPK signaling pathway	0.0	35.0	44.0	-0.043	0.058	1000.0	-1000.0	-0.018	-1000.0
Arf1 pathway	0.0	2.0	54.0	-0.001	0.046	1000.0	-1000.0	-0.015	-1000.0
Alternative NF-kappaB pathway	0.0	5.0	13.0	-0.0	0.066	1000.0	-1000.0	-0.0	-1000.0
Regulation of Androgen receptor activity	0.0	60.0	70.0	-0.192	0.057	1000.0	-1000.0	-0.043	-1000.0
Total	130	10629	7203	-13.8468317651	-991.781064375	131000	-131000	-3.69450896438	-131000