Clinical Features	CN_CNMF		METHLYATION_CNMF		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nCNV (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Chi-square test_P	Chi-square test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
1p gain	25 (15%)	140	0.30306	1	0.24596	1	0.092456	1	0.27157	1	0.56709	1	0.10936	1	0.64065	1	0.087527	1
1q gain	93 (56%)	72	6.736e-07	0.000428	0.010169	1	0.0080144	1	0.023235	1	0.19973	1	0.86386	1	0.6066	1	0.56979	1
2p gain	23 (14%)	142	0.050409	1	0.48098	1	0.027996	1	0.28435	1	0.31151	1	0.49247	1	0.10512	1	0.77322	1
2q gain	19 (12%)	146	0.012713	1	0.64762	1	0.28715	1	0.49502	1	0.13885	1	0.46938	1	0.42915	1	0.78411	1
3p gain	16 (10%)	149	0.12087	1	0.2105	1	0.01394	1	0.10307	1	0.44143	1	0.3961	1	0.1312	1	0.32444	1
3q gain	17 (10%)	148	0.068577	1	0.22214	1	0.020052	1	0.087604	1	0.28895	1	0.59453	1	0.14161	1	0.55384	1
4p gain	11 (7%)	154	0.11723	1	0.66956	1	0.055974	1	0.59365	1	0.18243	1	0.54597	1	0.73095	1	0.78568	1
4q gain	4 (2%)	161	1	1	0.81383	1	0.21004	1	1	1	1	1	0.59288	1	1	1	0.57395	1
5p gain	63 (38%)	102	0.0026313	1	0.012596	1	0.32652	1	0.44998	1	0.84199	1	0.25194	1	0.91272	1	0.6734	1
5q gain	47 (28%)	118	0.0014354	0.877	0.1415	1	0.074682	1	0.43704	1	0.93135	1	0.80173	1	0.81993	1	0.77758	1
6p gain	43 (26%)	122	0.00034307	0.213	0.026719	1	0.13313	1	0.14323	1	0.94182	1	0.78371	1	0.87678	1	0.66562	1
6q gain	30 (18%)	135	0.011927	1	0.17919	1	0.083248	1	0.11304	1	0.86751	1	0.67678	1	0.37365	1	0.68993	1
7p gain	50 (30%)	115	0.039248	1	0.093832	1	0.92002	1	0.67366	1	0.20074	1	0.10758	1	0.39646	1	0.47408	1
7q gain	51 (31%)	114	0.22458	1	0.012145	1	0.56862	1	0.65811	1	0.1472	1	0.16216	1	0.36651	1	0.65202	1
8p gain	33 (20%)	132	0.0393	1	0.51733	1	0.00019207	0.12	0.01367	1	0.84335	1	0.113	1	0.09916	1	0.097979	1
8q gain	83 (50%)	82	3.2669e-14	2.09e-11	0.74009	1	0.00015352	0.0963	0.0032584	1	0.11551	1	0.79175	1	0.54498	1	0.62643	1
9p gain	8 (5%)	157	0.24765	1	0.088236	1	0.27007	1	0.28548	1	0.90384	1	0.57955	1	0.43663	1	1	1
9q gain	8 (5%)	157	0.53431	1	0.52842	1	0.32757	1	0.28548	1	0.43548	1	0.57955	1	0.43663	1	1	1
10p gain	23 (14%)	142	0.39627	1	0.082198	1	0.10375	1	0.019889	1	0.27648	1	1	1	0.23673	1	0.84843	1
10q gain	12 (7%)	153	0.021817	1	0.081374	1	0.3454	1	0.69002	1	0.060198	1	0.67627	1	0.63697	1	0.80738	1
11p gain	10 (6%)	155	0.26841	1	0.31257	1	0.38931	1	0.87973	1	0.10041	1	0.58237	1	0.50056	1	0.26147	1
11q gain	11 (7%)	154	0.45456	1	0.24392	1	0.43844	1	0.55462	1	0.25637	1	0.74245	1	0.91788	1	0.63845	1
12p gain	14 (8%)	151	0.29376	1	0.28376	1	0.40379	1	0.17126	1	0.85432	1	0.12727	1	1	1	0.16226	1
12q gain	19 (12%)	146	0.81359	1	0.69437	1	0.21248	1	0.14083	1	1	1	0.27678	1	0.75879	1	0.38097	1
13q gain	10 (6%)	155	0.10528	1	0.31257	1	0.049949	1	0.21183	1	0.11073	1	0.16044	1	0.13551	1	0.11347	1
14q gain	10 (6%)	155	0.2236	1	0.33807	1	0.83666	1	0.64298	1	0.35693	1	0.14206	1	0.55151	1	0.34964	1
15q gain	14 (8%)	151	1	1	0.87412	1	0.55368	1	0.20872	1	0.089482	1	0.15291	1	0.39269	1	0.15792	1
16p gain	11 (7%)	154	0.031183	1	1	1	0.72032	1	0.90679	1	0.24439	1	0.51935	1	0.82605	1	0.50726	1
16q gain	5 (3%)	160	0.37858	1	1	1	0.23529	1	0.56191	1	0.23915	1	0.45871	1	0.29591	1	0.4428	1
17p gain	14 (8%)	151	0.45097	1	0.064779	1	0.64058	1	0.39571	1	0.93376	1	0.6656	1	0.85582	1	0.88906	1
17q gain	42 (25%)	123	0.027966	1	0.22006	1	0.045528	1	0.034691	1	0.76265	1	0.51965	1	1	1	0.69916	1
18p gain	13 (8%)	152	0.076209	1	0.26038	1	0.024496	1	0.02029	1	0.32533	1	0.11583	1	0.39269	1	0.093505	1
18q gain	12 (7%)	153	0.14545	1	0.27517	1	0.02839	1	0.04296	1	0.53547	1	0.12727	1	0.53024	1	0.10789	1
19p gain	33 (20%)	132	0.060127	1	6.2499e-05	0.0395	0.027391	1	0.023457	1	0.1261	1	0.12297	1	0.01384	1	0.10848	1
19q gain	37 (22%)	128	0.037425	1	0.00015165	0.0952	0.009075	1	0.022852	1	0.14532	1	0.066954	1	0.0063665	1	0.047051	1
20p gain	47 (28%)	118	0.0012472	0.763	0.0035976	1	0.0025722	1	0.0087222	1	0.71698	1	0.16563	1	0.02411	1	0.13462	1
20q gain	49 (30%)	116	0.0027029	1	0.019254	1	0.011341	1	0.013088	1	0.61052	1	0.32797	1	0.074594	1	0.28718	1
21q gain	15 (9%)	150	0.103	1	0.45302	1	0.03687	1	0.10307	1	0.87995	1	0.29036	1	0.93049	1	0.25943	1
22q gain	19 (12%)	146	0.018065	1	0.4138	1	0.095042	1	0.028011	1	0.25269	1	0.70654	1	0.32649	1	0.63744	1
xq gain	30 (18%)	135	0.00071553	0.441	0.015218	1	0.35002	1	0.049927	1	0.36136	1	0.13267	1	0.016031	1	0.12762	1
1p loss	38 (23%)	127	0.0057099	1	6.4931e-05	0.041	0.0023362	1	0.0093586	1	0.029876	1	0.093973	1	0.63914	1	0.15711	1
1q loss	11 (7%)	154	1	1	0.25702	1	0.58736	1	0.25862	1	0.2348	1	0.42717	1	0.15228	1	0.29528	1
2p loss	15 (9%)	150	0.048068	1	0.54168	1	0.14257	1	0.78354	1	0.073797	1	0.17936	1	0.42816	1	0.17843	1
2q loss	16 (10%)	149	0.046916	1	0.44296	1	0.35647	1	0.78354	1	0.0094409	1	0.10154	1	0.17135	1	0.090127	1
3p loss	19 (12%)	146	0.14896	1	0.026269	1	0.00013267	0.0834	0.00077181	0.475	0.56782	1	0.1272	1	0.030528	1	0.049509	1
3q loss	11 (7%)	154	0.45456	1	0.29041	1	0.59755	1	0.31586	1	0.013834	1	0.50073	1	0.3852	1	0.4855	1
4p loss	38 (23%)	127	0.0011906	0.73	0.15762	1	0.00012647	0.0797	0.26916	1	0.94333	1	0.57146	1	0.29825	1	0.41442	1
4q loss	54 (33%)	111	9.8782e-09	6.3e-06	0.022495	1	0.00080212	0.493	0.54105	1	0.47959	1	0.85005	1	0.38497	1	0.90715	1
5p loss	10 (6%)	155	0.20302	1	1	1	0.44533	1	0.26707	1	0.78188	1	0.14206	1	0.078808	1	0.89232	1
5q loss	15 (9%)	150	0.30402	1	0.096203	1	0.73083	1	0.40564	1	0.94128	1	0.63974	1	0.82161	1	1	1
6p loss	19 (12%)	146	0.30224	1	0.93874	1	0.032788	1	0.73246	1	0.053855	1	0.38413	1	0.32472	1	0.4362	1
6q loss	45 (27%)	120	0.24208	1	0.78005	1	0.034711	1	0.62431	1	0.48002	1	0.26856	1	0.23819	1	0.37504	1
7p loss	10 (6%)	155	0.84714	1	0.21232	1	0.0025501	1	0.71598	1	0.49769	1	0.65075	1	1	1	0.64181	1
7q loss	14 (8%)	151	0.73976	1	0.67975	1	0.00017508	0.11	0.69975	1	0.93376	1	0.09294	1	0.85582	1	0.28971	1
8p loss	78 (47%)	87	0.0036866	1	0.0024775	1	0.26308	1	0.8453	1	0.050972	1	0.12859	1	0.13622	1	0.069303	1
8q loss	16 (10%)	149	0.00022872	0.142	0.5912	1	0.00070385	0.434	0.25641	1	1	1	0.11583	1	0.17637	1	0.20463	1
9p loss	51 (31%)	114	0.02548	1	0.70046	1	0.43958	1	0.26069	1	0.22353	1	0.35662	1	0.56861	1	0.50436	1
9q loss	51 (31%)	114	0.12452	1	0.77069	1	0.032584	1	0.03212	1	0.34287	1	0.34085	1	0.2713	1	0.24802	1
10p loss	22 (13%)	143	0.22569	1	0.86162	1	0.0017043	1	0.15786	1	0.1136	1	0.37707	1	0.81103	1	0.34865	1
10q loss	38 (23%)	127	0.048741	1	1	1	2.1198e-05	0.0134	0.081259	1	0.2932	1	0.17773	1	0.45726	1	0.12342	1
11p loss	30 (18%)	135	0.56197	1	0.78438	1	0.22598	1	0.21658	1	0.62423	1	0.39525	1	0.27295	1	0.6697	1
11q loss	33 (20%)	132	0.79354	1	0.78327	1	0.22978	1	0.31436	1	1	1	0.92232	1	0.83182	1	1	1
12p loss	36 (22%)	129	0.32655	1	0.19167	1	0.027705	1	0.51001	1	0.27417	1	0.76696	1	0.75591	1	0.64991	1
12q loss	21 (13%)	144	0.10316	1	0.51255	1	0.040928	1	0.60921	1	0.91313	1	0.53945	1	0.88253	1	0.47119	1
13q loss	57 (35%)	108	0.0043793	1	0.12874	1	2.5563e-05	0.0162	0.016498	1	0.595	1	0.29895	1	0.057627	1	0.3196	1
14q loss	47 (28%)	118	0.00042854	0.265	0.24791	1	0.00030876	0.192	0.0019094	1	0.30271	1	0.85935	1	0.56587	1	0.67061	1
15q loss	32 (19%)	133	0.003237	1	0.33106	1	0.079745	1	0.2542	1	0.92852	1	0.65438	1	0.24793	1	0.6359	1
16p loss	49 (30%)	116	0.027569	1	0.11131	1	8.0589e-09	5.15e-06	0.00032308	0.201	0.2096	1	0.0055176	1	0.0018856	1	0.0027481	1
16q loss	61 (37%)	104	0.0034357	1	0.019713	1	1.7698e-07	0.000113	0.0002083	0.13	0.034225	1	0.073163	1	0.33145	1	0.11662	1
17p loss	86 (52%)	79	2.5343e-06	0.00161	0.32649	1	0.18834	1	0.20263	1	0.0079843	1	0.004601	1	0.59459	1	0.011437	1
17q loss	22 (13%)	143	0.2469	1	0.88542	1	0.016666	1	0.14993	1	0.649	1	0.79527	1	0.011675	1	1	1
18p loss	30 (18%)	135	0.013075	1	0.018829	1	0.33068	1	0.80322	1	0.44266	1	0.54454	1	0.74109	1	0.7077	1
18q loss	33 (20%)	132	0.0017182	1	0.021868	1	0.19191	1	0.28274	1	0.5719	1	0.56627	1	0.50144	1	0.46328	1
19p loss	21 (13%)	144	0.022969	1	0.51255	1	0.055617	1	0.90391	1	0.33295	1	0.28409	1	0.57896	1	0.24012	1
19q loss	15 (9%)	150	0.048068	1	0.49337	1	0.10912	1	0.5946	1	0.38458	1	0.614	1	0.38616	1	0.62061	1
20p loss	10 (6%)	155	0.095336	1	0.91873	1	0.00050181	0.31	0.59365	1	0.3479	1	0.48101	1	0.2348	1	0.4052	1
20q loss	6 (4%)	159	0.13115	1	0.8753	1	0.12607	1	0.92445	1	0.32416	1	0.52157	1	0.57359	1	0.51534	1
21q loss	45 (27%)	120	0.065053	1	0.49987	1	0.028631	1	0.36545	1	0.01205	1	0.35327	1	0.2659	1	0.25908	1
22q loss	40 (24%)	125	0.40803	1	0.19503	1	0.073127	1	0.43578	1	0.51685	1	0.85344	1	0.9171	1	0.88313	1
xq loss	24 (15%)	141	0.012026	1	0.054777	1	0.27362	1	0.4113	1	0.32176	1	0.76502	1	0.57621	1	0.74815	1