Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.432 0.296 -9999.0 0.0 -0.693 225.0 225.0 IHH -0.47 0.385 -9999.0 0.0 -0.811 269.0 269.0 SHH Np/Cholesterol/GAS1 -0.071 0.166 -9999.0 0.0 -0.456 71.0 71.0 LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.071 0.165 0.453 71.0 -9999.0 0.0 71.0 SMO/beta Arrestin2 -0.362 0.251 -9999.0 0.0 -0.593 233.0 233.0 SMO -0.381 0.272 -9999.0 0.0 -0.601 274.0 274.0 AKT1 -0.151 0.109 -9999.0 0.0 -0.323 3.0 3.0 ARRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.005 0.06 -9999.0 0.0 -0.656 4.0 4.0 ADRBK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.375 0.267 -9999.0 0.0 -0.591 274.0 274.0 STIL -0.329 0.248 -9999.0 0.0 -0.529 251.0 251.0 DHH N/PTCH2 -0.046 0.155 -9999.0 0.0 -0.563 39.0 39.0 DHH N/PTCH1 -0.364 0.244 -9999.0 0.0 -0.538 294.0 294.0 PIK3CA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.052 0.19 -9999.0 0.0 -0.741 34.0 34.0 PTHLH -0.581 0.357 -9999.0 0.0 -0.918 225.0 225.0 determination of left/right symmetry -0.375 0.267 -9999.0 0.0 -0.591 274.0 274.0 PIK3R1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.574 0.35 -9999.0 0.0 -0.905 225.0 225.0 IHH N/Hhip -0.654 0.378 -9999.0 0.0 -0.821 383.0 383.0 DHH N/Hhip -0.408 0.295 -9999.0 0.0 -0.596 330.0 330.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.375 0.267 -9999.0 0.0 -0.591 274.0 274.0 pancreas development -0.494 0.348 -9999.0 0.0 -0.739 322.0 322.0 HHAT 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.012 0.095 -9999.0 0.0 -0.741 8.0 8.0 somite specification -0.375 0.267 -9999.0 0.0 -0.591 274.0 274.0 SHH Np/Cholesterol/PTCH1 -0.352 0.252 -9999.0 0.0 -0.553 255.0 255.0 SHH Np/Cholesterol/PTCH2 -0.069 0.159 -9999.0 0.0 -0.431 77.0 77.0 SHH Np/Cholesterol/Megalin -0.288 0.269 -9999.0 0.0 -0.5 276.0 276.0 SHH -0.066 0.202 -9999.0 0.0 -0.546 72.0 72.0 catabolic process -0.372 0.253 -9999.0 0.0 -0.568 282.0 282.0 SMO/Vitamin D3 -0.372 0.266 -9999.0 0.0 -0.593 248.0 248.0 SHH Np/Cholesterol/Hhip -0.357 0.26 -9999.0 0.0 -0.504 340.0 340.0 LRP2 -0.38 0.37 -9999.0 0.0 -0.741 247.0 247.0 receptor-mediated endocytosis -0.499 0.312 -9999.0 0.0 -0.718 281.0 281.0 SHH Np/Cholesterol/BOC -0.067 0.16 -9999.0 0.0 -0.436 74.0 74.0 SHH Np/Cholesterol/CDO -0.069 0.158 -9999.0 0.0 -0.441 70.0 70.0 mesenchymal cell differentiation 0.354 0.257 0.5 340.0 -9999.0 0.0 340.0 mol:Vitamin D3 -0.35 0.261 -9999.0 0.0 -0.559 255.0 255.0 IHH N/PTCH2 -0.306 0.269 -9999.0 0.0 -0.54 269.0 269.0 CDON -0.008 0.075 -9999.0 0.0 -0.741 5.0 5.0 IHH N/PTCH1 -0.377 0.257 -9999.0 0.0 -0.576 282.0 282.0 Megalin/LRPAP1 -0.286 0.279 -9999.0 0.0 -0.559 247.0 247.0 PTCH2 -0.009 0.076 -9999.0 0.0 -0.684 6.0 6.0 SHH Np/Cholesterol -0.065 0.156 -9999.0 0.0 -0.435 72.0 72.0 PTCH1 -0.373 0.254 -9999.0 0.0 -0.57 282.0 282.0 HHIP -0.495 0.349 -9999.0 0.0 -0.741 322.0 322.0