Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.16 0.232 -9999.0 0.0 -0.733 29.0 29.0 IHH -0.303 0.312 -9999.0 0.0 -0.588 259.0 259.0 SHH Np/Cholesterol/GAS1 -0.03 0.123 0.197 1.0 -0.327 68.0 69.0 LRPAP1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.03 0.122 0.325 68.0 -0.195 1.0 69.0 SMO/beta Arrestin2 -0.203 0.226 -9999.0 0.0 -0.397 250.0 250.0 SMO -0.219 0.228 -9999.0 0.0 -0.413 257.0 257.0 AKT1 -0.109 0.155 -9999.0 0.0 -0.562 31.0 31.0 ARRB2 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.019 0.041 0.238 2.0 -0.559 2.0 4.0 ADRBK1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.216 0.225 -9999.0 0.0 -0.408 257.0 257.0 STIL -0.175 0.187 0.238 1.0 -0.462 76.0 77.0 DHH N/PTCH2 0.0 0.119 -9999.0 0.0 -0.422 34.0 34.0 DHH N/PTCH1 -0.18 0.207 -9999.0 0.0 -0.333 289.0 289.0 PIK3CA 0.012 0.012 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.022 0.149 -9999.0 0.0 -0.559 34.0 34.0 PTHLH -0.197 0.263 -9999.0 0.0 -0.749 27.0 27.0 determination of left/right symmetry -0.216 0.225 -9999.0 0.0 -0.408 257.0 257.0 PIK3R1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.195 0.261 -9999.0 0.0 -0.741 27.0 27.0 IHH N/Hhip -0.437 0.287 -9999.0 0.0 -0.575 369.0 369.0 DHH N/Hhip -0.275 0.229 -9999.0 0.0 -0.44 302.0 302.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.216 0.225 -9999.0 0.0 -0.408 257.0 257.0 pancreas development -0.335 0.28 -9999.0 0.0 -0.558 293.0 293.0 HHAT 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.017 0.017 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.014 0.07 -9999.0 0.0 -0.559 7.0 7.0 somite specification -0.216 0.225 -9999.0 0.0 -0.408 257.0 257.0 SHH Np/Cholesterol/PTCH1 -0.179 0.197 -9999.0 0.0 -0.323 281.0 281.0 SHH Np/Cholesterol/PTCH2 -0.027 0.119 0.197 1.0 -0.324 64.0 65.0 SHH Np/Cholesterol/Megalin -0.191 0.201 -9999.0 0.0 -0.362 261.0 261.0 SHH -0.062 0.136 0.297 1.0 -0.414 61.0 62.0 catabolic process -0.18 0.21 -9999.0 0.0 -0.353 271.0 271.0 SMO/Vitamin D3 -0.204 0.223 -9999.0 0.0 -0.381 257.0 257.0 SHH Np/Cholesterol/Hhip -0.233 0.194 -9999.0 0.0 -0.366 302.0 302.0 LRP2 -0.271 0.29 -9999.0 0.0 -0.559 241.0 241.0 receptor-mediated endocytosis -0.318 0.261 -9999.0 0.0 -0.576 203.0 203.0 SHH Np/Cholesterol/BOC -0.024 0.111 -9999.0 0.0 -0.327 54.0 54.0 SHH Np/Cholesterol/CDO -0.028 0.12 0.197 1.0 -0.324 66.0 67.0 mesenchymal cell differentiation 0.232 0.193 0.364 302.0 -9999.0 0.0 302.0 mol:Vitamin D3 -0.176 0.204 0.247 2.0 -0.326 279.0 281.0 IHH N/PTCH2 -0.185 0.205 -9999.0 0.0 -0.371 257.0 257.0 CDON 0.016 0.059 -9999.0 0.0 -0.559 5.0 5.0 IHH N/PTCH1 -0.174 0.222 -9999.0 0.0 -0.357 271.0 271.0 Megalin/LRPAP1 -0.19 0.221 -9999.0 0.0 -0.409 241.0 241.0 PTCH2 0.02 0.048 0.238 2.0 -0.559 3.0 5.0 SHH Np/Cholesterol -0.034 0.111 -9999.0 0.0 -0.321 61.0 61.0 PTCH1 -0.181 0.21 -9999.0 0.0 -0.355 271.0 271.0 HHIP -0.336 0.281 -9999.0 0.0 -0.559 293.0 293.0