Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.018 0.007 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.044 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.009 0.083 -9999.0 0.0 -0.559 10.0 10.0 ENAH 0.009 0.07 0.276 10.0 -9999.0 0.0 10.0 EGFR 0.022 0.084 0.363 11.0 -0.559 6.0 17.0 EPHA2 0.018 0.046 -9999.0 0.0 -0.559 3.0 3.0 MYO6 -0.008 0.026 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.033 0.057 -9999.0 0.0 -0.356 8.0 8.0 AQP5 -0.137 0.226 -9999.0 0.0 -0.482 141.0 141.0 CTNND1 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.009 0.023 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.085 0.128 -9999.0 0.0 -0.292 130.0 130.0 EGF 0.015 0.072 0.238 3.0 -0.559 7.0 10.0 NCKAP1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.06 0.168 -9999.0 0.0 -0.475 65.0 65.0 cortical microtubule organization 0.044 0.016 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 -0.009 0.022 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.049 0.018 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.019 0.023 -9999.0 0.0 -0.275 3.0 3.0 ARF6 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.043 0.039 -9999.0 0.0 -0.328 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.001 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.009 0.024 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.046 0.041 -9999.0 0.0 -0.308 3.0 3.0 CDH1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF 0.03 0.062 -9999.0 0.0 -0.315 12.0 12.0 RhoA/GDP 0.045 0.017 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.011 0.021 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.005 0.102 0.238 1.0 -0.559 15.0 16.0 DIAPH1 -0.015 0.164 -9999.0 0.0 -0.575 20.0 20.0 Wnt receptor signaling pathway -0.044 0.016 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.019 0.023 -9999.0 0.0 -0.274 3.0 3.0 CTNNA1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.011 0.021 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.008 0.015 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 0.036 0.031 -9999.0 0.0 -0.293 3.0 3.0 SEC6/SEC8 -0.015 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.087 0.13 -9999.0 0.0 -0.296 130.0 130.0 HGF/MET -0.025 0.129 -9999.0 0.0 -0.284 93.0 93.0 HGF -0.092 0.231 -9999.0 0.0 -0.559 94.0 94.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.018 0.007 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.047 0.1 0.308 27.0 -9999.0 0.0 27.0 KIAA1543 -0.009 0.021 0.161 5.0 -9999.0 0.0 5.0 KIFC3 -0.01 0.022 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.019 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.018 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.009 0.025 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.028 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.044 0.016 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.009 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.009 0.024 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.019 0.086 0.298 19.0 -9999.0 0.0 19.0 adherens junction assembly -0.014 0.094 0.282 3.0 -0.65 7.0 10.0 IGF-1R heterotetramer/IGF1 0.03 0.056 -9999.0 0.0 -0.287 13.0 13.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.021 0.041 0.376 1.0 -0.559 2.0 3.0 PLEKHA7 -0.01 0.022 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.041 0.038 -9999.0 0.0 -0.326 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.025 0.084 0.313 8.0 -9999.0 0.0 8.0 cortical actin cytoskeleton stabilization 0.018 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion -0.011 0.021 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.018 0.007 -9999.0 0.0 -9999.0 0.0 0.0