Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.136 0.276 -9999.0 0.0 -0.568 42.0 42.0 IHH -0.015 0.089 -9999.0 0.0 -0.538 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.044 0.143 -9999.0 0.0 -0.325 29.0 29.0 LRPAP1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.044 0.142 0.323 29.0 -9999.0 0.0 29.0 SMO/beta Arrestin2 -0.115 0.235 -9999.0 0.0 -0.583 20.0 20.0 SMO -0.13 0.24 -9999.0 0.0 -0.599 21.0 21.0 AKT1 -0.091 0.213 -9999.0 0.0 -0.701 13.0 13.0 ARRB2 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.022 0.026 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.127 0.236 -9999.0 0.0 -0.588 21.0 21.0 STIL -0.076 0.159 -9999.0 0.0 -0.458 11.0 11.0 DHH N/PTCH2 0.046 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.05 0.163 -9999.0 0.0 -0.301 42.0 42.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.512 2.0 2.0 DHH 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.25 0.45 -9999.0 0.0 -0.959 43.0 43.0 determination of left/right symmetry -0.127 0.236 -9999.0 0.0 -0.588 21.0 21.0 PIK3R1 0.004 0.099 -9999.0 0.0 -0.512 5.0 5.0 skeletal system development -0.246 0.444 -9999.0 0.0 -0.945 43.0 43.0 IHH N/Hhip -0.056 0.157 -9999.0 0.0 -0.424 21.0 21.0 DHH N/Hhip -0.025 0.136 -9999.0 0.0 -0.373 19.0 19.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.127 0.236 -9999.0 0.0 -0.588 21.0 21.0 pancreas development -0.059 0.179 -9999.0 0.0 -0.511 20.0 20.0 HHAT -0.007 0.14 -9999.0 0.0 -0.512 11.0 11.0 PI3K 0.004 0.075 -9999.0 0.0 -0.373 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.057 0.188 -9999.0 0.0 -0.512 22.0 22.0 somite specification -0.127 0.236 -9999.0 0.0 -0.588 21.0 21.0 SHH Np/Cholesterol/PTCH1 -0.069 0.164 -9999.0 0.0 -0.387 17.0 17.0 SHH Np/Cholesterol/PTCH2 0.007 0.086 -9999.0 0.0 -0.288 12.0 12.0 SHH Np/Cholesterol/Megalin 0.001 0.091 -9999.0 0.0 -0.295 13.0 13.0 SHH -0.013 0.104 -9999.0 0.0 -0.373 12.0 12.0 catabolic process -0.07 0.173 -9999.0 0.0 -0.337 43.0 43.0 SMO/Vitamin D3 -0.102 0.206 -9999.0 0.0 -0.518 19.0 19.0 SHH Np/Cholesterol/Hhip -0.044 0.128 -9999.0 0.0 -0.298 29.0 29.0 LRP2 0.02 0.052 -9999.0 0.0 -0.512 1.0 1.0 receptor-mediated endocytosis -0.101 0.196 -9999.0 0.0 -0.507 18.0 18.0 SHH Np/Cholesterol/BOC -0.001 0.086 -9999.0 0.0 -0.288 12.0 12.0 SHH Np/Cholesterol/CDO 0.005 0.087 -9999.0 0.0 -0.291 12.0 12.0 mesenchymal cell differentiation 0.044 0.127 0.296 29.0 -9999.0 0.0 29.0 mol:Vitamin D3 -0.069 0.165 -9999.0 0.0 -0.456 11.0 11.0 IHH N/PTCH2 0.015 0.06 -9999.0 0.0 -0.326 1.0 1.0 CDON 0.028 0.02 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.063 0.18 -9999.0 0.0 -0.339 43.0 43.0 Megalin/LRPAP1 0.033 0.044 -9999.0 0.0 -0.373 1.0 1.0 PTCH2 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.005 0.082 -9999.0 0.0 -0.287 12.0 12.0 PTCH1 -0.07 0.174 -9999.0 0.0 -0.338 43.0 43.0 HHIP -0.059 0.179 -9999.0 0.0 -0.512 20.0 20.0