Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.015 0.112 -9999.0 0.0 -0.293 18.0 18.0 epithelial cell differentiation 0.034 0.093 -9999.0 0.0 -0.27 12.0 12.0 CYFIP2 0.025 0.046 -9999.0 0.0 -0.512 1.0 1.0 ENAH -0.013 0.108 0.282 2.0 -0.332 6.0 8.0 EGFR -0.033 0.17 -9999.0 0.0 -0.512 17.0 17.0 EPHA2 -0.015 0.146 -9999.0 0.0 -0.512 12.0 12.0 MYO6 -0.011 0.091 -9999.0 0.0 -0.284 14.0 14.0 CTNNB1 0.028 0.015 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.049 0.051 -9999.0 0.0 -0.318 2.0 2.0 AQP5 -0.063 0.173 -9999.0 0.0 -0.478 20.0 20.0 CTNND1 0.015 0.096 -9999.0 0.0 -0.512 5.0 5.0 mol:PI-4-5-P2 -0.008 0.079 -9999.0 0.0 -0.257 13.0 13.0 regulation of calcium-dependent cell-cell adhesion -0.026 0.104 -9999.0 0.0 -0.284 19.0 19.0 EGF -0.033 0.151 -9999.0 0.0 -0.512 13.0 13.0 NCKAP1 0.025 0.047 -9999.0 0.0 -0.512 1.0 1.0 AQP3 -0.1 0.195 -9999.0 0.0 -0.48 29.0 29.0 cortical microtubule organization 0.034 0.093 -9999.0 0.0 -0.27 12.0 12.0 GO:0000145 -0.027 0.07 -9999.0 0.0 -0.245 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.039 0.096 -9999.0 0.0 -0.273 12.0 12.0 MLLT4 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.054 0.111 -9999.0 0.0 -0.348 14.0 14.0 ARF6 0.024 0.062 -9999.0 0.0 -0.512 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.022 0.122 -9999.0 0.0 -0.356 12.0 12.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.017 0.065 -9999.0 0.0 -0.274 1.0 1.0 PVRL2 0.027 0.045 -9999.0 0.0 -0.512 1.0 1.0 ZYX -0.012 0.081 -9999.0 0.0 -0.261 14.0 14.0 ARF6/GTP 0.023 0.129 -9999.0 0.0 -0.347 13.0 13.0 CDH1 0.005 0.114 -9999.0 0.0 -0.512 7.0 7.0 EGFR/EGFR/EGF/EGF -0.043 0.155 -9999.0 0.0 -0.32 32.0 32.0 RhoA/GDP 0.036 0.09 -9999.0 0.0 -0.256 12.0 12.0 actin cytoskeleton organization -0.034 0.095 -9999.0 0.0 -0.312 13.0 13.0 IGF-1R heterotetramer -0.008 0.14 -9999.0 0.0 -0.511 11.0 11.0 GIT1 0.024 0.062 -9999.0 0.0 -0.512 2.0 2.0 IGF1R -0.008 0.14 -9999.0 0.0 -0.512 11.0 11.0 IGF1 -0.05 0.182 -9999.0 0.0 -0.512 20.0 20.0 DIAPH1 0.01 0.176 -9999.0 0.0 -0.62 6.0 6.0 Wnt receptor signaling pathway -0.034 0.093 0.27 12.0 -9999.0 0.0 12.0 RHOA 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.051 0.103 -9999.0 0.0 -0.31 18.0 18.0 CTNNA1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.035 0.097 -9999.0 0.0 -0.319 13.0 13.0 EFNA1 0.019 0.076 -9999.0 0.0 -0.512 3.0 3.0 LPP -0.022 0.063 -9999.0 0.0 -0.256 9.0 9.0 Ephrin A1/EPHA2 -0.001 0.13 -9999.0 0.0 -0.305 21.0 21.0 SEC6/SEC8 -0.007 0.067 -9999.0 0.0 -0.252 10.0 10.0 MGAT3 -0.026 0.105 -9999.0 0.0 -0.288 19.0 19.0 HGF/MET 0.022 0.091 -9999.0 0.0 -0.256 13.0 13.0 HGF 0.029 0.018 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.015 0.113 -9999.0 0.0 -0.295 18.0 18.0 actin cable formation 0.035 0.125 0.313 6.0 -0.297 4.0 10.0 KIAA1543 -0.025 0.069 -9999.0 0.0 -0.249 12.0 12.0 KIFC3 -0.005 0.075 -9999.0 0.0 -0.261 11.0 11.0 NCK1 0.019 0.062 -9999.0 0.0 -0.512 2.0 2.0 EXOC3 0.026 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.006 0.078 -9999.0 0.0 -0.263 12.0 12.0 NCK1/GIT1 0.028 0.062 -9999.0 0.0 -0.373 3.0 3.0 mol:GDP 0.034 0.093 -9999.0 0.0 -0.27 12.0 12.0 EXOC4 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.002 0.072 -9999.0 0.0 -0.261 10.0 10.0 PIP5K1C -0.008 0.08 -9999.0 0.0 -0.26 13.0 13.0 LIMA1 -0.0 0.128 -9999.0 0.0 -0.512 9.0 9.0 ABI1 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.01 0.128 0.291 4.0 -0.391 6.0 10.0 adherens junction assembly -0.015 0.1 -9999.0 0.0 -0.485 3.0 3.0 IGF-1R heterotetramer/IGF1 -0.04 0.149 -9999.0 0.0 -0.289 36.0 36.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.042 0.036 -9999.0 0.0 -0.373 1.0 1.0 MET 0.02 0.076 -9999.0 0.0 -0.512 3.0 3.0 PLEKHA7 -0.006 0.078 -9999.0 0.0 -0.261 12.0 12.0 mol:GTP 0.021 0.121 -9999.0 0.0 -0.354 12.0 12.0 establishment of epithelial cell apical/basal polarity 0.011 0.108 0.383 3.0 -0.293 1.0 4.0 cortical actin cytoskeleton stabilization -0.015 0.112 -9999.0 0.0 -0.293 18.0 18.0 regulation of cell-cell adhesion -0.034 0.095 -9999.0 0.0 -0.312 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.015 0.113 -9999.0 0.0 -0.295 18.0 18.0