Clinical Features CN_CNMF METHLYATION_CNMF MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nCNV (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q 1p gain 6 (7%) 75 0.86894 1 0.8672 1 0.91307 1 0.78246 1 1 1 0.8399 1 0.83436 1 0.83828 1 1q gain 19 (23%) 62 0.24644 1 0.072213 1 0.060248 1 0.11697 1 0.2028 1 0.86107 1 0.673 1 0.6865 1 2p gain 6 (7%) 75 0.023596 1 0.043345 1 0.044891 1 0.01559 1 0.10671 1 0.40659 1 0.13765 1 0.27103 1 2q gain 7 (9%) 74 0.0080282 1 0.017716 1 0.019137 1 0.0092025 1 0.037508 1 0.2261 1 0.05638 1 0.16625 1 3p gain 4 (5%) 77 0.25629 1 0.15333 1 0.25992 1 0.12217 1 0.28853 1 1 1 0.38505 1 1 1 3q gain 9 (11%) 72 0.11571 1 0.0037488 1 0.058744 1 0.056163 1 0.10834 1 0.25469 1 0.15129 1 0.19482 1 4p gain 3 (4%) 78 0.60643 1 0.60335 1 0.88473 1 0.68302 1 1 1 0.77249 1 0.5714 1 0.78934 1 4q gain 3 (4%) 78 0.60643 1 0.60335 1 0.88473 1 0.68302 1 1 1 0.77249 1 0.5714 1 0.78934 1 5p gain 9 (11%) 72 0.075528 1 0.1019 1 0.31426 1 0.19458 1 0.30461 1 0.74022 1 0.46088 1 0.64301 1 5q gain 5 (6%) 76 0.70843 1 0.43668 1 0.57736 1 0.53266 1 0.81053 1 0.38992 1 0.50939 1 0.32743 1 7p gain 19 (23%) 62 0.063876 1 0.0052958 1 0.070278 1 0.061853 1 0.033955 1 0.11737 1 0.037013 1 0.092094 1 7q gain 17 (21%) 64 0.15923 1 0.011356 1 0.070278 1 0.061853 1 0.033955 1 0.11737 1 0.037013 1 0.092094 1 8p gain 10 (12%) 71 0.11514 1 0.046698 1 0.024388 1 0.018512 1 0.10834 1 0.25469 1 0.15129 1 0.19482 1 8q gain 21 (26%) 60 0.0067785 1 0.00099287 0.462 4.4231e-05 0.0222 8.8313e-05 0.044 0.0013 0.602 0.0027544 1 0.0014589 0.673 0.0014272 0.659 9p gain 3 (4%) 78 0.60643 1 0.32836 1 0.25992 1 0.12217 1 0.28853 1 0.2886 1 0.20583 1 0.30062 1 9q gain 4 (5%) 77 0.25629 1 0.11538 1 0.25992 1 0.12217 1 0.28853 1 0.2886 1 0.20583 1 0.30062 1 10q gain 4 (5%) 77 0.01689 1 0.03009 1 NA NA NA NA NA NA NA NA NA NA NA NA 11p gain 7 (9%) 74 0.1063 1 0.027415 1 0.24405 1 0.4319 1 0.64184 1 0.12204 1 0.53995 1 0.10689 1 11q gain 7 (9%) 74 0.1063 1 0.24023 1 0.1329 1 0.11879 1 0.30461 1 0.098196 1 0.16063 1 0.082513 1 12p gain 8 (10%) 73 0.00041069 0.199 0.014513 1 0.044891 1 0.035521 1 0.022523 1 0.13836 1 0.03834 1 0.092034 1 12q gain 6 (7%) 75 0.0076077 1 0.053332 1 0.12256 1 0.081424 1 0.037508 1 0.2261 1 0.05638 1 0.16625 1 13q gain 6 (7%) 75 1 1 0.28982 1 1 1 0.74398 1 0.50909 1 0.055106 1 0.16515 1 0.065996 1 14q gain 9 (11%) 72 0.075528 1 0.47599 1 0.2338 1 0.24521 1 0.70596 1 0.71377 1 0.80014 1 0.65017 1 15q gain 6 (7%) 75 0.29968 1 0.19517 1 0.48377 1 1 1 0.15057 1 0.57818 1 1 1 0.50067 1 16p gain 8 (10%) 73 0.0027884 1 0.014513 1 0.1329 1 0.11879 1 0.16099 1 0.13836 1 0.03834 1 0.092034 1 16q gain 9 (11%) 72 0.0024961 1 0.0049857 1 0.024388 1 0.049006 1 0.10834 1 0.061447 1 0.01384 1 0.041297 1 17q gain 4 (5%) 77 0.25629 1 0.11538 1 0.12256 1 0.058847 1 0.23165 1 0.12603 1 0.091593 1 0.13348 1 18p gain 10 (12%) 71 2.7764e-05 0.014 0.00042055 0.204 0.019137 1 0.0092025 1 0.022523 1 0.01311 1 0.0046303 1 0.0087395 1 18q gain 3 (4%) 78 0.10711 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA 19p gain 4 (5%) 77 0.073899 1 0.44801 1 0.57736 1 0.53266 1 0.39405 1 0.66081 1 0.50939 1 0.53089 1 19q gain 9 (11%) 72 0.25915 1 0.47599 1 0.2338 1 0.24521 1 0.39555 1 0.31634 1 0.55304 1 0.89437 1 20p gain 13 (16%) 68 0.00034899 0.17 0.0036456 1 0.058744 1 0.056163 1 0.043589 1 0.14905 1 0.06073 1 0.12207 1 20q gain 17 (21%) 64 0.0010125 0.47 0.046067 1 0.036015 1 0.020884 1 0.042065 1 0.11769 1 0.017943 1 0.092613 1 22q gain 4 (5%) 77 0.049437 1 0.047395 1 0.25992 1 0.12217 1 0.28853 1 1 1 0.38505 1 1 1 xq gain 3 (4%) 78 1 1 1 1 NA NA NA NA NA NA NA NA NA NA NA NA 1p loss 11 (14%) 70 0.00047843 0.231 0.00031306 0.153 0.57736 1 0.53266 1 0.31765 1 0.69946 1 0.59141 1 0.7021 1 1q loss 3 (4%) 78 0.011357 1 0.10359 1 NA NA NA NA NA NA NA NA NA NA NA NA 2p loss 6 (7%) 75 0.098636 1 0.22395 1 1 1 0.78246 1 0.84806 1 0.74022 1 0.46088 1 0.64301 1 3p loss 12 (15%) 69 0.00091251 0.427 0.12032 1 0.2338 1 0.40566 1 0.30599 1 0.33875 1 0.19634 1 0.34259 1 3q loss 6 (7%) 75 0.023596 1 0.26243 1 0.57736 1 0.53266 1 0.39405 1 0.66081 1 0.50939 1 0.53089 1 4p loss 9 (11%) 72 0.012097 1 0.1019 1 0.49455 1 0.11879 1 0.2518 1 0.2261 1 0.05638 1 0.16625 1 4q loss 8 (10%) 73 0.030984 1 0.0094143 1 0.66678 1 0.19458 1 0.57097 1 0.19452 1 0.31157 1 0.20578 1 5p loss 3 (4%) 78 0.011357 1 0.32836 1 NA NA NA NA NA NA NA NA NA NA NA NA 5q loss 7 (9%) 74 0.00073235 0.349 0.027415 1 0.25992 1 0.12217 1 0.10671 1 0.40659 1 0.13765 1 0.27103 1 6p loss 28 (35%) 53 8.4781e-05 0.0423 9.0024e-06 0.00456 0.00076275 0.362 0.007082 1 0.017813 1 0.00078284 0.37 0.00087031 0.408 0.0031113 1 6q loss 34 (42%) 47 0.00021895 0.108 2.6814e-07 0.000136 0.00031391 0.154 4.6199e-07 0.000235 0.00020948 0.104 3.456e-05 0.0174 5.3129e-05 0.0267 0.00017002 0.0845 8p loss 11 (14%) 70 0.03082 1 0.035292 1 0.058744 1 0.056163 1 0.043589 1 0.0098869 1 0.018102 1 0.0073896 1 9p loss 34 (42%) 47 7.8804e-05 0.0394 0.037702 1 0.27673 1 0.045534 1 0.17777 1 0.43086 1 0.2441 1 0.36685 1 9q loss 20 (25%) 61 0.2098 1 0.54965 1 0.67845 1 0.69378 1 0.35546 1 0.52744 1 0.75407 1 0.6986 1 10p loss 13 (16%) 68 0.00815 1 0.12032 1 0.019015 1 0.00078621 0.371 0.0019229 0.885 0.00086189 0.406 0.00021188 0.105 0.00055387 0.267 10q loss 12 (15%) 69 0.00058133 0.279 0.18003 1 0.069615 1 0.0066641 1 0.0084422 1 0.0040823 1 0.00061072 0.293 0.0026872 1 11p loss 6 (7%) 75 0.033879 1 0.8672 1 0.025726 1 0.61513 1 0.0053556 1 0.11728 1 0.24808 1 0.12918 1 11q loss 6 (7%) 75 0.29968 1 0.75514 1 0.1732 1 0.43648 1 0.29932 1 0.52292 1 0.65847 1 0.67061 1 12p loss 8 (10%) 73 0.030984 1 0.15206 1 0.044891 1 0.01559 1 0.10671 1 0.069284 1 0.035676 1 0.044692 1 12q loss 10 (12%) 71 0.00073804 0.351 0.063558 1 0.058744 1 0.056163 1 0.11083 1 0.13836 1 0.03834 1 0.092034 1 13q loss 10 (12%) 71 0.00073804 0.351 0.28149 1 0.25204 1 0.074331 1 0.04781 1 0.061447 1 0.01384 1 0.041297 1 14q loss 4 (5%) 77 1 1 0.03009 1 NA NA NA NA 1 1 0.41373 1 1 1 0.42702 1 15q loss 11 (14%) 70 0.0030209 1 0.00022866 0.112 0.0023309 1 0.00031505 0.154 0.0019229 0.885 0.00086189 0.406 0.00021188 0.105 0.00055387 0.267 17p loss 33 (41%) 48 4.5895e-09 2.34e-06 2.1254e-11 1.09e-08 0.002645 1 0.00018447 0.0915 0.00065952 0.315 0.00092123 0.43 6.1912e-05 0.031 0.00037221 0.181 17q loss 11 (14%) 70 0.00096666 0.45 0.02528 1 0.3199 1 0.37381 1 0.41863 1 0.69383 1 0.20335 1 0.61458 1 18p loss 29 (36%) 52 0.50295 1 0.072698 1 0.57522 1 0.84918 1 0.80928 1 1 1 0.40655 1 0.86342 1 18q loss 44 (54%) 37 0.0034965 1 0.0021333 0.977 0.22527 1 0.19317 1 0.20499 1 0.080176 1 0.061992 1 0.14434 1 19p loss 7 (9%) 74 0.071105 1 0.24023 1 0.10171 1 0.0092025 1 0.022523 1 0.13836 1 0.03834 1 0.092034 1 19q loss 5 (6%) 76 0.26137 1 0.52156 1 0.32121 1 0.058847 1 0.10671 1 0.069284 1 0.035676 1 0.044692 1 20p loss 7 (9%) 74 0.43799 1 0.12855 1 0.66678 1 0.25655 1 0.31765 1 0.40659 1 0.31157 1 0.27103 1 21q loss 28 (35%) 53 1.7856e-06 0.000905 0.0053303 1 0.13454 1 0.016153 1 0.026853 1 0.22408 1 0.074119 1 0.15973 1 22q loss 16 (20%) 65 0.0035312 1 0.068525 1 0.2338 1 0.40566 1 0.39555 1 0.56135 1 0.21545 1 0.45279 1 xq loss 5 (6%) 76 0.0040845 1 0.43668 1 0.36558 1 1 1 0.11557 1 0.57998 1 0.073892 1 0.58711 1