Clinical Features	CN_CNMF		METHLYATION_CNMF		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
C15ORF24	6 (11%)	51	0.23801	1	0.74812	1	0.62234	1	0.24812	1	0.62107	1	0.84754	1	0.21421	1	0.26061	1
IRS1	5 (9%)	52	0.33621	1	0.50587	1	0.74136	1	1	1	0.83283	1	1	1	0.71125	1	1	1
FYN	5 (9%)	52	0.12605	1	0.24399	1	0.038272	1	0.097207	1	0.16372	1	0.45096	1	0.091879	1	0.069281	1
FADS2	5 (9%)	52	1	1	0.7117	1	0.41157	1	1	1	0.21526	1	0.096385	1	0.71125	1	0.023923	1
C14ORF49	9 (16%)	48	0.30989	1	0.11712	1	0.2592	1	0.23303	1	0.14901	1	0.19123	1	0.44142	1	0.23875	1
FGF10	6 (11%)	51	1	1	0.10271	1	0.62234	1	0.42268	1	0.15489	1	0.84754	1	0.091073	1	0.26061	1
CEL	4 (7%)	53	0.65954	1	1	1	0.039666	1	0.74266	1	0.11235	1	0.81215	1	0.39119	1	0.29033	1
CCR3	5 (9%)	52	0.70016	1	0.7117	1	0.73782	1	1	1	0.58207	1	0.69371	1	0.83051	1	0.83221	1
OR10A2	6 (11%)	51	0.33928	1	0.080023	1	0.038272	1	0.13184	1	0.056988	1	0.048202	1	0.27184	1	0.10934	1
OR10A7	9 (16%)	48	0.71813	1	0.34215	1	0.097093	1	0.4148	1	0.39615	1	0.7863	1	0.62188	1	0.48984	1
POP5	5 (9%)	52	0.12605	1	0.15461	1	0.019893	1	0.13184	1	0.02897	1	0.45096	1	0.091879	1	0.069281	1
SRP14	7 (12%)	50	1	1	1	1	0.93229	1	0.51387	1	0.75798	1	0.49194	1	0.20387	1	0.42561	1
WRN	5 (9%)	52	0.32916	1	0.84523	1	0.91382	1	0.611	1	0.69109	1	1	1	1	1	1	1
TMEM40	9 (16%)	48	0.69113	1	0.34215	1	0.56731	1	1	1	0.56131	1	0.7863	1	0.31716	1	1	1
KRAS	33 (58%)	24	0.047918	1	0.00097927	0.82	0.050551	1	0.015805	1	0.080464	1	0.13293	1	0.20741	1	0.28639	1
TP53	37 (65%)	20	0.071307	1	0.0052174	1	0.12476	1	0.09916	1	0.41864	1	0.38948	1	0.30156	1	0.49656	1
QRICH1	7 (12%)	50	0.068706	1	0.12347	1	0.38622	1	0.08455	1	0.42622	1	0.11982	1	0.0044475	1	0.11014	1
ST6GALNAC5	6 (11%)	51	1	1	0.35584	1	0.65517	1	0.81975	1	1	1	1	1	0.72129	1	1	1
TNFSF9	6 (11%)	51	0.23801	1	0.74812	1	0.16915	1	0.1348	1	0.45099	1	0.84754	1	0.11216	1	0.85085	1
CDKN2A	13 (23%)	44	0.41302	1	0.10995	1	0.5986	1	0.87554	1	0.21268	1	0.81951	1	0.90644	1	0.75281	1
SEH1L	8 (14%)	49	0.40508	1	0.38829	1	0.58889	1	0.60773	1	0.68867	1	0.088863	1	0.033867	1	0.10388	1
SCD	8 (14%)	49	0.40508	1	0.38829	1	0.093047	1	1	1	0.35715	1	0.76986	1	0.59968	1	0.27508	1
TMC4	9 (16%)	48	0.88874	1	0.21448	1	0.39007	1	0.15268	1	0.13624	1	0.51565	1	0.67593	1	0.46165	1
MED15	9 (16%)	48	1	1	0.8165	1	0.66491	1	0.37466	1	0.63206	1	1	1	0.49225	1	1	1
TNFRSF9	6 (11%)	51	1	1	0.5489	1	0.59454	1	0.611	1	0.52658	1	0.43613	1	0.85688	1	0.63017	1
BRDT	8 (14%)	49	0.40508	1	0.38829	1	0.47862	1	0.83587	1	0.050295	1	0.39098	1	0.46665	1	0.52169	1
CXXC4	6 (11%)	51	0.70016	1	0.74812	1	0.93229	1	0.64496	1	0.85512	1	0.52083	1	1	1	0.54068	1
MBD3	6 (11%)	51	1	1	0.86647	1	0.6887	1	0.77059	1	0.45099	1	1	1	1	1	1	1
TULP1	6 (11%)	51	0.23801	1	0.5489	1	0.22666	1	0.42268	1	0.056988	1	0.11452	1	0.27184	1	0.0085397	1
PHF13	4 (7%)	53	0.65954	1	0.081611	1	0.23609	1	0.11838	1	0.32251	1	0.49905	1	0.092228	1	0.65696	1
BHLHB9	5 (9%)	52	0.25455	1	0.050696	1	0.11843	1	0.048502	1	0.08922	1	0.072981	1	0.035278	1	0.036352	1
PRDM8	6 (11%)	51	0.23801	1	0.74812	1	0.91382	1	1	1	0.23527	1	0.080635	1	0.21421	1	0.072878	1
SMAD4	10 (18%)	47	0.11259	1	0.040193	1	0.23506	1	0.1816	1	0.07254	1	0.33536	1	0.13447	1	0.20873	1
C14ORF43	7 (12%)	50	0.65518	1	0.14491	1	0.35536	1	0.58352	1	1	1	1	1	0.57817	1	0.65792	1
MEPCE	7 (12%)	50	0.1473	1	0.59228	1	0.47862	1	0.83587	1	0.23343	1	0.06033	1	0.13772	1	0.087086	1
HVCN1	4 (7%)	53	0.65954	1	1	1	0.039666	1	0.74266	1	0.11235	1	0.078897	1	0.39119	1	0.015502	1
FOXP2	8 (14%)	49	0.78242	1	0.62523	1	0.47862	1	0.83587	1	0.050295	1	0.19215	1	0.27531	1	0.31628	1
GRIN1	5 (9%)	52	0.41	1	0.7117	1	0.093201	1	1	1	0.21526	1	1	1	0.48526	1	0.24726	1
MAGEA10	4 (7%)	53	0.16377	1	0.34947	1	0.084316	1	0.1893	1	0.07284	1	0.49905	1	0.1696	1	0.059062	1
C16ORF79	4 (7%)	53	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
ERF	6 (11%)	51	0.33928	1	0.18207	1	0.13803	1	0.611	1	0.075886	1	0.15379	1	0.27184	1	0.26061	1
IFNGR2	4 (7%)	53	0.65954	1	0.27232	1	0.20945	1	0.51055	1	0.65957	1	0.49905	1	0.66261	1	0.65696	1
OLIG3	5 (9%)	52	0.70016	1	0.59335	1	0.18127	1	0.01914	1	0.08922	1	0.3668	1	0.11448	1	0.31286	1
NDEL1	4 (7%)	53	0.65954	1	1	1	0.039666	1	0.74266	1	0.11235	1	0.81215	1	0.39119	1	0.29033	1
EGR1	8 (14%)	49	0.69113	1	0.70459	1	0.81738	1	0.81975	1	0.46238	1	0.87214	1	0.31485	1	0.88118	1
CDH3	4 (7%)	53	0.79882	1	0.27232	1	0.022202	1	0.43108	1	0.051107	1	0.36243	1	0.39119	1	0.38289	1
PCDHAC2	9 (16%)	48	0.27239	1	0.0367	1	0.82017	1	0.32863	1	0.88207	1	1	1	0.67593	1	1	1
ZFP36	4 (7%)	53	0.79882	1	0.34947	1	0.10287	1	0.43108	1	0.43118	1	0.36243	1	0.39119	1	0.38289	1
NR4A3	5 (9%)	52	0.32916	1	0.050696	1	0.85457	1	0.77059	1	1	1	0.83665	1	1	1	1	1
RAB11FIP5	5 (9%)	52	0.5841	1	0.24399	1	0.45132	1	0.74266	1	0.83283	1	1	1	0.71125	1	1	1
OTUD4	7 (12%)	50	0.20526	1	1	1	0.29844	1	1	1	0.66046	1	1	1	0.76092	1	0.65792	1
PPARGC1B	7 (12%)	50	1	1	0.59228	1	0.93834	1	0.70662	1	0.87323	1	0.49194	1	0.086015	1	0.65792	1
PDZD2	9 (16%)	48	0.56978	1	0.4617	1	0.51268	1	0.53374	1	0.50571	1	0.19123	1	0.068787	1	0.055761	1
NPNT	4 (7%)	53	0.33621	1	1	1	0.73782	1	0.74266	1	0.65957	1	0.81215	1	1	1	1	1
MED9	3 (5%)	54	0.28232	1	0.013131	1	NA	NA	NA	NA	0.58929	1	1	1	1	1	1	1
BCL2L1	3 (5%)	54	0.79495	1	0.78182	1	0.76688	1	0.28924	1	0.58929	1	1	1	0.58214	1	1	1
CPLX3	3 (5%)	54	0.41414	1	0.6026	1	0.20315	1	0.43108	1	0.066276	1	0.1123	1	0.13776	1	0.12903	1
IRX4	3 (5%)	54	0.79495	1	0.78182	1	0.24311	1	1	1	0.30357	1	0.55408	1	0.78571	1	0.77607	1
NFAT5	8 (14%)	49	0.78242	1	0.38829	1	0.56731	1	0.86213	1	0.78301	1	0.51565	1	0.88562	1	0.88118	1
WASF3	5 (9%)	52	0.5841	1	0.24399	1	0.20945	1	0.51055	1	0.58207	1	0.69371	1	1	1	0.83221	1
ABCC2	6 (11%)	51	0.23801	1	0.18207	1	0.25539	1	0.42268	1	0.52658	1	0.15379	1	0.27184	1	0.26061	1
ATP13A3	4 (7%)	53	0.53021	1	0.27232	1	1	1	1	1	1	1	1	1	0.82675	1	1	1
ARHGAP18	4 (7%)	53	0.41414	1	0.34947	1	0.070995	1	0.1893	1	0.07284	1	0.36243	1	0.1696	1	0.1648	1
CIR1	3 (5%)	54	1	1	0.6026	1	NA	NA	NA	NA	0.1875	1	0.75474	1	0.58214	1	0.77607	1
KIAA0020	4 (7%)	53	0.79882	1	0.27232	1	0.10287	1	0.43108	1	0.43118	1	1	1	0.39119	1	0.65696	1
ZNF608	6 (11%)	51	0.068706	1	0.10271	1	0.62234	1	0.42268	1	0.15489	1	0.15379	1	0.0455	1	0.018357	1
NEDD4L	6 (11%)	51	1	1	0.46643	1	0.81738	1	0.81975	1	0.73252	1	0.3599	1	0.85688	1	0.31696	1
THBS4	6 (11%)	51	0.33928	1	0.10271	1	0.13803	1	0.611	1	0.52658	1	0.84754	1	0.21421	1	0.26061	1
MMRN1	6 (11%)	51	1	1	0.74812	1	0.91382	1	1	1	0.73252	1	0.84754	1	0.62588	1	0.85085	1
GPR25	3 (5%)	54	0.41414	1	0.6026	1	1	1	1	1	0.78571	1	0.1123	1	0.29286	1	0.12903	1
SORBS2	6 (11%)	51	0.52208	1	0.030653	1	1	1	1	1	1	1	1	1	1	1	1	1
SULT1C3	3 (5%)	54	0.79495	1	0.10166	1	0.88011	1	0.66698	1	0.58929	1	1	1	1	1	1	1
ECSIT	4 (7%)	53	0.65954	1	1	1	0.039666	1	0.74266	1	0.11235	1	0.81215	1	0.39119	1	0.29033	1
ZNF326	4 (7%)	53	0.79882	1	0.27232	1	0.24311	1	1	1	0.65957	1	0.49905	1	0.66261	1	0.65696	1
C15ORF52	3 (5%)	54	1	1	0.6026	1	NA	NA	NA	NA	0.78571	1	0.55408	1	0.78571	1	0.77607	1
SLC39A5	3 (5%)	54	0.79495	1	0.78182	1	1	1	1	1	0.78571	1	0.75474	1	0.58214	1	0.77607	1
SLC24A1	4 (7%)	53	0.16377	1	0.34947	1	0.45132	1	0.74266	1	0.43118	1	0.11256	1	0.1696	1	0.1648	1
PUM2	5 (9%)	52	0.41	1	0.7117	1	0.63763	1	1	1	0.83283	1	1	1	0.31221	1	0.24726	1
SYT2	5 (9%)	52	0.12605	1	0.024901	1	0.15042	1	0.13184	1	0.02897	1	0.042464	1	0.091879	1	0.069281	1
SLITRK5	6 (11%)	51	0.23801	1	0.74812	1	0.25539	1	1	1	0.52658	1	0.84754	1	0.21421	1	0.26061	1
NAP1L3	3 (5%)	54	1	1	0.78182	1	0.24311	1	1	1	0.30357	1	0.55408	1	0.78571	1	0.77607	1
PHF14	3 (5%)	54	0.79495	1	0.78182	1	1	1	1	1	0.78571	1	0.55408	1	0.78571	1	0.77607	1
CCDC28B	4 (7%)	53	0.16377	1	0.34947	1	0.014235	1	0.11838	1	0.11235	1	0.81215	1	0.1696	1	0.29033	1
PDE12	3 (5%)	54	NA	NA	0.6026	1	NA	NA	NA	NA	0.78571	1	0.75474	1	0.78571	1	0.77607	1
FLAD1	3 (5%)	54	0.41414	1	0.17468	1	0.10287	1	0.43108	1	0.11735	1	0.18209	1	0.13776	1	0.20755	1
ENG	3 (5%)	54	0.41414	1	0.17468	1	0.10287	1	0.43108	1	0.11735	1	0.03	1	0.29286	1	0.039184	1
PABPC1	4 (7%)	53	0.53021	1	0.5557	1	0.76688	1	1	1	1	1	1	1	1	1	1	1
ATG16L2	3 (5%)	54	1	1	0.33074	1	0.24311	1	1	1	0.30357	1	0.37571	1	0.78571	1	0.079592	1
LRCH1	7 (12%)	50	0.65518	1	0.45095	1	0.29844	1	1	1	0.66046	1	0.65537	1	0.76092	1	0.22559	1
PLCZ1	3 (5%)	54	1	1	0.33074	1	0.24311	1	1	1	0.30357	1	1	1	0.78571	1	0.77607	1
TAOK2	6 (11%)	51	1	1	1	1	1	1	0.64496	1	1	1	0.84754	1	0.11216	1	0.85085	1
ZMIZ1	6 (11%)	51	0.1495	1	0.86647	1	0.55398	1	0.46256	1	0.85512	1	1	1	0.3321	1	1	1
SYT15	6 (11%)	51	1	1	0.061696	1	0.81738	1	0.81975	1	1	1	0.72412	1	0.85688	1	0.85085	1
LRTM1	3 (5%)	54	0.41414	1	0.17468	1	0.0034536	1	0.28924	1	1	1	0.37571	1	0.58214	1	0.39219	1
TIMM50	4 (7%)	53	0.33621	1	0.5557	1	0.40772	1	1	1	0.79939	1	0.81215	1	0.82675	1	1	1
CCNK	4 (7%)	53	0.65954	1	1	1	0.29604	1	1	1	0.65957	1	0.49905	1	0.66261	1	0.65696	1
TTK	5 (9%)	52	0.12605	1	0.24399	1	0.59454	1	0.34287	1	0.83283	1	0.22387	1	0.071299	1	0.24726	1
TMEM175	4 (7%)	53	0.65954	1	0.34947	1	0.67606	1	0.74266	1	0.32251	1	0.027347	1	0.1696	1	0.032332	1
CD93	5 (9%)	52	1	1	0.0074841	1	0.55398	1	0.23491	1	0.48328	1	0.83665	1	0.38357	1	1	1
C19ORF55	4 (7%)	53	0.53021	1	0.028895	1	0.88011	1	0.66698	1	0.54103	1	1	1	0.82675	1	1	1
MRPL48	3 (5%)	54	1	1	0.6026	1	1	1	1	1	0.78571	1	0.1123	1	0.04102	1	0.12903	1
PVRL1	5 (9%)	52	0.41	1	0.84523	1	0.093201	1	1	1	0.21526	1	0.45096	1	0.48526	1	0.47798	1
ACIN1	3 (5%)	54	1	1	0.33074	1	NA	NA	NA	NA	0.58929	1	0.75474	1	0.58214	1	0.77607	1
MAML3	7 (12%)	50	0.87885	1	0.14491	1	0.49964	1	0.46415	1	0.32462	1	0.74128	1	1	1	1	1
EDC4	5 (9%)	52	1	1	0.7117	1	0.49547	1	0.66698	1	1	1	1	1	0.38357	1	1	1
SETD1A	3 (5%)	54	0.79495	1	1	1	1	1	1	1	0.78571	1	1	1	0.58214	1	0.77607	1